γ-Secretase Inhibitors & Modulators: DAPT

Cat. No.: A37272

CAS No.: 2070009-70-8

LY-411575 (isomer 2)

LY-411575 (isomer 2) is a potent inhibitor of γ-secretase, an enzyme involved in the cleavage of amyloid precursor protein and a key player in the pathogenesis of Alzheimer's disease. This compound has been shown to effectively reduce the production of amyloid-beta peptides, making it valuable for research into therapeutic strategies for neurodegenerative disorders. Its selective inhibition of γ-secretase also facilitates the study of its role in cellular signaling and development.

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Cat. No.: A37273

CAS No.: 443989-01-3

GSI-136

GSI-136 is a potent inhibitor of γ-secretase, exhibiting an IC50 of 3 nM. This compound effectively reduces Aβ40 levels in diethylamine-extracted brain homogenates from C57BL/6 mice in a dose-dependent manner. GSI-136 serves as a valuable tool in medicinal chemistry and Alzheimer’s disease research, aiding in the exploration of therapeutic strategies targeting amyloid-beta production.

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Cat. No.: A37274

CAS No.: 209984-58-7

LY-411575 (isomer 1)

LY-411575 (isomer 1) is a potent γ-secretase inhibitor that selectively modulates the enzyme's activity. This compound is primarily utilized in the investigation of Alzheimer’s disease pathogenesis by reducing the production of harmful amyloid-beta peptides. Its mechanism of action allows for a deeper understanding of γ-secretase's role in cellular signaling and pathology, making it a valuable tool in neurological research.

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1 mg

$760.00

5 mg

$1,035.00

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Cat. No.: A37275

CAS No.: 2070009-28-6

LY-411575 (isomer 3)

LY-411575 (isomer 3) is a potent inhibitor of γ-secretase, an enzyme complex involved in the proteolytic processing of various transmembrane proteins, including amyloid precursor protein (APP). This compound is utilized in research studying Alzheimer's disease and other conditions associated with aberrant Notch signaling. Its ability to modulate γ-secretase activity makes it a valuable tool for investigating the therapeutic potential of targeting this pathway.

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Cat. No.: A37276

CAS No.: 851599-82-1

ELN318463 racemate

ELN318463 racemate is a selective γ-secretase inhibitor targeting the amyloid precursor protein (APP). It demonstrates differential inhibition of presenilin (PS1) and PS2-comprised γ-secretase, with EC50 values of 12 nM for PS1 and 656 nM for PS2, indicating a 51-fold selectivity for PS1. This compound is useful in research applications focused on Alzheimer's disease and the modulation of amyloid beta peptide production.

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1 mg

$130.00

5 mg

$340.00

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Cat. No.: A78416

CAS No.: 1353570-40-7

γ-Secretase modulator 13

γ-Secretase modulator 13 is a gamma-secretase modulator that inhibits the production of the aggregated amyloid β-peptide Aβ42, exhibiting an IC50 value of 163 nM. This compound is valuable for research in Alzheimer's disease, facilitating investigations into amyloidogenic processes and potential therapeutic interventions. Its specific modulation of γ-secretase activity positions it as a significant tool for studying the mechanisms underlying neurodegenerative disorders.

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Cat. No.: B19546

CAS No.: 1093975-58-6

PSEN1-IN-3

PSEN1-IN-3 is a modulator of the gamma secretase complex, primarily targeting the presenilin-1 component. This compound plays a critical role in the regulation of amyloid precursor protein (APP) processing, thereby influencing amyloid-beta peptide production. PSEN1-IN-3 is utilized in research related to Alzheimer's disease and other neurodegenerative disorders, aiding in the investigation of gamma secretase's role in pathology and potential therapeutic interventions.

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