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CXCR

CXCR antagonists block CXC chemokine receptors, chiefly CXCR4 and the interleukin-8 receptors CXCR1 and CXCR2. CXC chemokine receptor 4 (CXCR4) binds CXC motif chemokine ligand 12 (CXCL12), also called stromal cell-derived factor 1 (SDF-1), and guides the homing of hematopoietic and immune cells. In 1996 CXCR4 was identified as an entry coreceptor for T-cell-tropic human immunodeficiency virus type 1 (HIV-1). Plerixafor and mavorixafor are CXCR4 antagonists used in studies of stem cell mobilization, cell migration and viral entry. CXCR1 and CXCR2 respond to interleukin-8 (CXCL8) and recruit neutrophils, a process studied with navarixin and reparixin.

3 Items

  • SRT3109
    Cat. No.
    A11097
    CAS No.
    1204707-71-0

    SRT3109

    SRT3109 is a CXCR2 ligand for use in the treatment of chemokine mediated diseases and conditions.

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    2 mg
    $30.00
    5 mg
    $45.00
    All 7 sizes
  • SDNUM04
    Cat. No.
    A59824
    CAS No.
    3113549-20-2

    SDNUM04

    SDNUM04 is a ligand for the C-X-C chemokine receptor 4 (CXCR4), known for its role in cell migration and metastasis. This compound can be utilized as a tracer in tumor-targeting studies, facilitating research on cancer biology and the mechanisms of tumor progression. Additionally, SDNUM04 may serve as a valuable tool in drug discovery and development focused on CXCR4-related pathways.

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    Out of stock

    All 3 sizes

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