MCHR1 (GPR24)

Cat. No.

A61612

CAS No.

359784-84-2

[Ala17]-MCH

[Ala17]-MCH is a selective ligand for the melanin-concentrating hormone receptor 1 (MCHR1), exhibiting a Ki value of 0.16 nM, indicating strong affinity compared to MCHR2, which has a Ki of 34 nM. The Eu3+ chelate-labeled form demonstrates high binding affinity for MCHR1 with a Kd of 0.37 nM, while showing negligible interaction with MCHR2. This compound is valuable for research applications involving MCHR1-mediated pathways, particularly in the study of neuropeptide signaling and metabolic regulation.

Cat. No.

A61618

CAS No.

128315-56-0

MCH(human, mouse, rat)

Synonyms: Melanin-concentrating hormone(human, mouse, rat)

MCH (human, mouse, rat) is a cyclic neuropeptide that functions as an endogenous ligand for the melanin-concentrating hormone receptor (MCH-R). It exhibits high binding affinity with IC50 values of 0.3 nM and 1.5 nM for human MCH-1R and MCH-2R, respectively, and operational EC50 values of 3.9 nM and 88.7 nM. MCH plays a crucial role in regulating appetite as an orexigenic signal and is instrumental in maintaining energy homeostasis and sleep-wake cycles. This reagent is essential for research into obesity, sleep-related disorders, and related metabolic conditions.