Somatostatin Receptors

Somatostatin receptor (SSTR) agonists and antagonists act on SSTR1 to SSTR5, five G protein-coupled receptors. Somatostatin was isolated from hypothalamus in 1973 as a peptide that inhibits growth hormone secretion from the pituitary. Its receptors couple mainly to inhibitory G proteins, lower cyclic adenosine monophosphate (cAMP) and suppress hormone release in the pituitary, pancreas and gut. Human and mouse somatostatin receptors were cloned in 1992 and found in brain, gastrointestinal tract and kidney. The natural peptide is listed together with cyclic somatostatin, octreotide acetate and pasireotide L-aspartate salt, stable analogs with different subtype profiles. Subtype tools include the SSTR2 antagonist CYN-154806, the SSTR4 agonist J-2156, and SSTR5 antagonist 1 and SSTR5 antagonist 2.

3 Items

  • Edotreotide
    Cat. No.
    A41619

    Edotreotide

    Synonyms: DOTATOC; SDZ-SMT 487; SMT 487

    Edotreotide is a selective ligand for the somatostatin receptor subtype 2 (SSTR2), capable of competitive binding to the receptor. It facilitates the targeted delivery of radionuclides, such as 90Y, 177Lu, and 68Ga, to SSTR-positive tumors, promoting tumor cell apoptosis through the emission of β rays. Edotreotide's strong tumor-targeting capabilities make it a valuable tool in the development of radionuclide-drug conjugates (RDCs) and in research applications focused on neuroendocrine tumors, including metastatic carcinoids and lung and thymus neuroendocrine tumors.

    1 mg
    $50.00
    5 mg
    $135.00
    All 7 sizes
  • DOTA-NOC
    Cat. No.
    A41632

    DOTA-NOC

    Synonyms: DOTA-Nal3-octreotide

    DOTA-NOC (DOTA-Nal3-octreotide) is a high-affinity ligand for somatostatin receptor subtypes 2, 3, and 5. This compound is primarily utilized for radiolabeling with various radiometals, facilitating the development of radiopeptide imaging techniques. Additionally, DOTA-NOC plays a crucial role in the synthesis and research of Radionuclide-Drug Conjugates (RDCs), making it a valuable reagent in oncological and diagnostic studies.

    1 mg
    $80.00
    5 mg
    $215.00
    All 4 sizes
  • NOTA-TATE
    Cat. No.
    A63892

    NOTA-TATE

    NOTA-TATE is a selective somatostatin receptor 2 (SSTR2) binder. It specifically targets SSTR2-positive tumor cells, facilitating their visualization through PET imaging. This compound is particularly valuable in the research of neuroendocrine tumors, advancing both diagnostic and therapeutic applications in oncology.

    Out of stock

    All 3 sizes

3 Items

Added to your cart

View Cart Checkout

    Loading...