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Platelet-Activating Factor (PAF) Receptors

Platelet-activating factor (PAF) receptor antagonists block a G protein-coupled receptor for an inflammatory lipid. PAF is released by platelets, leukocytes and endothelial cells and promotes platelet aggregation, leukocyte activation and vascular permeability. The PAF receptor was cloned by functional expression from guinea pig lung in 1991. Ginkgolide B and ginkgolide A are terpene lactones from Ginkgo biloba that serve as classic natural PAF receptor antagonists. Foropafant, tulopafant and 48740 RP are synthetic antagonists developed for the same receptor. Rupatadine fumarate also blocks the histamine H1 receptor, and CP-96486 also blocks the leukotriene D4 (LTD4) receptor. Further ligands of these receptors are found under Histamine Receptors and Leukotriene Receptor.

1 Item

  • C16-PAF
    Cat. No.
    A24258
    CAS No.
    74389-68-7

    C16-PAF

    Synonyms: PAF (C16)

    C16-PAF (PAF (C16)) is a phospholipid mediator and a potent platelet-activating factor that functions as a ligand for the PAF G-protein-coupled receptor (PAFR). It exhibits anti-apoptotic effects by inhibiting caspase-dependent cell death through PAFR activation. C16-PAF is a strong activator of the MAPK and MEK/ERK signaling pathways and is known to induce increased vascular permeability.

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    1 mg
    $32.00
    5 mg
    $95.00
    All 4 sizes

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