- Cat. No.
- A11571
ST-836
ST-836 is a dopamine receptor ligand; Antiparkinsonian agent.
In stock
View Details
-
-
- Cat. No.
- A15249
ST-836 hydrochloride
ST-836 Hcl is a dopamine receptor ligand; Antiparkinsonian agent.
In stock View Details -
- Cat. No.
- A18261
Metergoline
Metergoline is a psychoactive drug of the ergoline chemical class which acts as a ligand for various serotonin and dopamine receptors.
In stock View Details -
- Cat. No.
- A29423
Dopamine D3 receptor ligand-5
Dopamine D3 Receptor Ligand-5 is a selective ligand for the dopamine D3 receptor, exhibiting a Ki value of 0.14 nM, indicating high affinity. Additionally, it also demonstrates significant interaction with the D2 receptor, possessing a Ki value of 2.85 nM. This compound is primarily utilized in neurological research to investigate dopamine signaling pathways and their implications in neuropsychiatric disorders. Its specificity for the D3 receptor makes it a valuable tool for studies on receptor pharmacology and therapeutic development.
In stock View Details -
- Cat. No.
- A29732
PZ-1190
PZ-1190 is a multitarget ligand that primarily interacts with serotonin and dopamine receptors, exhibiting potential antipsychotic activity. This compound has been studied in rodent models to explore its effects on psychotic behaviors. Its unique mechanism of action positions it as a valuable tool for research into psychiatric disorders and the underlying neurotransmitter systems.
Out of stock
All 3 sizes -
- Cat. No.
- A29989
Mosapramine
Synonyms: Clospipramine
Mosapramine is a D2 receptor binder that acts as an antipsychotic agent and is a metabolite of Clocapramine. It selectively binds to striatal dopamine D2 receptors and frontal lobe 5-HT2 receptors, exhibiting a D2/5-HT2 receptor occupancy ratio of 7.4. This compound induces characteristic neuropharmacological effects in rat models, including extrapyramidal symptoms, hyperprolactinemia, and increased salivation, while displaying a lower incidence of weight loss. Mosapramine is valuable for research applications related to schizophrenia and its underlying mechanisms.
In stock View Details -
- Cat. No.
- A57997
Heterobivalent ligand-1
Heterobivalent ligand-1 is a potent heterobivalent ligand targeting the Adenosine A2A-dopamine D2 receptor heteromer, exhibiting binding affinities of 2.1 nM for A2AR and 0.13 nM for D2R. This compound is valuable for studying receptor heteromerization and signal transduction in neurological research. Its unique design enables exploration of the functional interplay between these receptors in various biological contexts.
Out of stock
All 3 sizes -
- Cat. No.
- A59976
(-)-Isocorypalmine
Synonyms: Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine
(-)-Isocorypalmine is a potent ligand for dopamine receptors, specifically isolated from the crude base fraction of Corydalis chaerophylla. This compound demonstrates high affinity, with a Km value of 4.63 ± 0.71 μM, as confirmed by recombinant CYP719A21. It holds significant promise for research in neuropharmacology and studies related to dopamine signaling pathways.
In stock View Details -
- Cat. No.
- A59997
Dopamine D3 receptor ligand-3
Dopamine D3 receptor ligand-3 is a selective ligand for the D3 receptor, exhibiting a high affinity with a Ki value of 3.6 nM. This compound demonstrates significant selectivity for the D3 receptor over the D2 receptor, with a Ki of 353 nM. It serves as a valuable tool for research applications focusing on dopaminergic signaling and related neurological disorders.
Out of stock
All 3 sizes -
- Cat. No.
- A60005
Dopamine D3 receptor ligand-1
Dopamine D3 receptor ligand-1 is a potent and selective ligand for the dopamine D3 receptor, exhibiting a high affinity with a Ki value of 8 nM. This compound demonstrates an impressive 89-fold selectivity for the D3 receptor over the D2 receptor (D2 Ki = 715 nM). Its specificity makes it a valuable tool for investigating the D3 receptor's role in various neurobiological processes and for drug discovery efforts targeting dopamine-related disorders.
Out of stock
All 3 sizes -
- Cat. No.
- A60012
UNC0006
UNC0006 is a β-arrestin-biased ligand targeting the dopamine D2 receptor. This compound is primarily utilized in the investigation of antipsychotic mechanisms and their effects on dopamine signaling pathways. Its unique bias towards β-arrestin pathways may offer new insights into therapeutic strategies for psychiatric disorders.
In stock View Details -
- Cat. No.
- A60022
3'-Fluorobenzylspiperone maleate
3'-Fluorobenzylspiperone maleate is a selective ligand for dopamine D2 receptors, demonstrating significant potential in the modulation of dopaminergic activity. This compound has been shown to exhibit improved efficacy in alleviating behavioral disorders compared to placebo, making it a valuable tool for research into neuropsychiatric conditions and the pharmacological study of dopamine pathways. Its targeted action underscores its relevance in the investigation of dopamine-mediated therapeutic interventions.
In stock View Details -
- Cat. No.
- A60031
(-)-MDO-NPA
(-)-MDO-NPA is a dual-target ligand for dopamine receptors D1R and D2R, functioning as an N-propylnorapomorphine analog. It demonstrates β-arrestin EC50 values of 1949 nM for D1R and 520 nM for D2R, and cAMP EC50 values of 717.5 nM for D1R and 7.7 nM for D2R. This compound is particularly valuable for studying dopamine-related disorders, including Parkinson's disease, and contributes to understanding receptor signaling pathways in pharmacological research.
Out of stock
All 3 sizes -
- Cat. No.
- A60062
Dopamine D3 receptor ligand-4
Dopamine D3 receptor ligand-4 is a highly potent and selective ligand for the dopamine D3 receptor, exhibiting a Ki value of 0.5 nM. It demonstrates impressive selectivity for the D3 receptor over the D2 receptor, with a Ki of 7.43 nM. This compound is valuable for research applications focused on understanding dopamine-related pathways and potential therapeutic targets in neuropsychiatric disorders.
Out of stock
All 3 sizes -
- Cat. No.
- A60097
Dopamine D4 receptor ligand 2
Dopamine D4 receptor ligand 2 is a selective ligand targeting the dopamine D4 receptor, exhibiting a potent inhibitory effect with an IC50 of 0.057 nM. In contrast, the compound demonstrates much lower affinity for D2 (>1000 nM), 5-HT1A (220 nM), and α1 (270 nM) receptors. This selectivity positions it as a valuable tool for studies investigating the role of dopamine D4 in neuropharmacology and related research areas.
In stock View Details -
- Cat. No.
- A60100
UNC10099984A
UNC10099984A is a functionally selective ligand for the dopamine D2 receptor, exhibiting a Ki value of 4.6 nM and an EC50 value of 6.2 nM for β-arrestin. This compound is particularly valuable for investigating central nervous system disorders associated with D2 receptor modulation, facilitating research into dopamine signaling pathways and their therapeutic implications.
Out of stock
All 3 sizes -
- Cat. No.
- A60101
TISCH
TISCH is a potent and selective iodinated ligand that targets CNS D1 dopamine receptors, demonstrating a high affinity with a Kd value of 0.205 nM in rat striatal tissue. Its ability to cross the blood-brain barrier allows for effective distribution in regions with substantial D1 receptor density, making it a valuable pharmacological tool for characterizing these receptors. Additionally, TISCH, when labeled with I-123, has potential applications as an in vivo imaging agent for studying D1 dopamine receptor function in the central nervous system.
In stock View Details -
- Cat. No.
- A97071
1-Benzyl-3-methylpiperazine
Synonyms: 3-Methyl-1-benzyl-piperazine
1-Benzyl-3-methylpiperazine is a piperazine derivative that primarily functions as a monoamine receptor ligand. It exhibits significant activity at various serotonin and dopamine receptors, making it a valuable compound for research in neuropharmacology. This reagent is often utilized in studies exploring the effects of psychoactive substances and the mechanisms underlying mood regulation.
Out of stock
All 3 sizes