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Oxytocin receptor antagonists and agonists act on the receptor for the neurohypophysial hormone oxytocin. The human oxytocin receptor was cloned and characterized in 1992 as a member of the G protein-coupled receptor superfamily. In peripheral tissues it mediates uterine contraction and milk ejection, while central oxytocin signaling is studied in social behavior. Atosiban is a peptide antagonist that also binds the vasopressin V1a receptor. Retosiban, epelsiban and L-368,899 hydrochloride are nonpeptide oxytocin receptor antagonists. Carbetocin is a long-acting peptide agonist, and oxytocin itself serves as the reference ligand in binding and functional assays.
Synonyms: α-Hypophamine; Oxytocic hormone
Oxytocin (α-Hypophamine) is a mammalian neurohypophysial hormone; its actions are mediated by specific, high-affinity oxytocin receptors; ligand of oxytocin receptor.
Synonyms: α-Hypophamine acetate; Oxytocic hormone acetate
Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma.
Pro8-Oxytocin is a modified oxytocin (OXT) ligand that exhibits enhanced potency and efficacy at primate oxytocin receptors (OXTR) compared to Leu8-Oxytocin. This compound demonstrates significantly stronger behavioral effects, making it a valuable tool in neuropharmacology research. Additionally, Pro8-Oxytocin shows a lower efficacy than vasopressin at human AVPR1a receptors while producing a higher efficacy at marmoset AVPR1a receptors, positioning it as an important reagent for studying receptor specificity and ligand-receptor interactions.
