Neurokinin Receptors

Cat. No.

A16529

CAS No.

10402-53-6

Eprazinone dihydrochloride

Eprazinone dihydrochloride is a selective neurokinin 1 receptor (NK1R) ligand known for its mucolytic, secretolytic, antitussive, and bronchial antispasmodic properties. It exhibits significant potential in the treatment of chronic bronchitis, contributing to enhanced pulmonary function and improved arterial partial pressure of oxygen. This compound is valuable in research applications focused on respiratory disorders and the modulation of NK1 receptor pathways.

Cat. No.

A62091

CAS No.

38678-60-3

Leucyl-phenylalanine amide

Synonyms: L-Leucyl-L-phenylalaninamide

Leucyl-phenylalanine amide is a dipeptide analog that serves as a specific ligand for the SP1-7 receptor, exhibiting a binding affinity characterized by a Ki value of 10.2 nM. This compound is valuable for research focused on neuropeptide signaling pathways and can be utilized in studies exploring the functional roles of SP1-7 in various physiological contexts. Notably, it does not show binding activity to human NK-1 or NK-3 receptors, making it a selective tool for targeted biological investigations.

Cat. No.

A62120

CAS No.

15893-46-6

Phenylalanylphenylalanylamide

Synonyms: H-Phe-Phe-NH2

Phenylalanylphenylalanylamide (H-Phe-Phe-NH₂) functions as a potent ligand for the substance P 1–7 (SP1-7) binding site, exhibiting a Ki value of 1.5 nM. This compound demonstrates significant anti-allodynic and anti-hyperalgesic properties in animal models of neuropathic pain when administered centrally. However, it shows no distinct effects when delivered peripherally via intraperitoneal injection. Phenylalanylphenylalanylamide is valuable for investigations into pain-related disorders and therapeutic interventions.