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Melanocortin Receptor

Melanocortin receptor agonists and antagonists act on MC1R to MC5R, five receptors for melanocortin peptides. These peptides derive from proopiomelanocortin and include α-melanocyte-stimulating hormone (α-MSH) and adrenocorticotropic hormone (ACTH). Genes for the MSH receptor (MC1R) and the ACTH receptor (MC2R) were cloned in 1992. MC1R controls skin and hair pigmentation, while MC4R in the hypothalamus regulates feeding and energy balance. In a 1997 study, mice with a targeted disruption of the MC4R gene became obese. The list holds α-MSH, the ACTH fragment tetracosactide, and the cyclic peptides melanotan II and bremelanotide acetate. Setmelanotide and PF-00446687 are MC4R agonists, and JNJ-10229570 blocks MC1R and MC5R. Melanogenesis inhibitors such as orcinol are included as well, for pigmentation studies.

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  • (Phe2,Nle4)-ACTH (1-24) (human, bovine, rat)
    Cat. No.
    A61676
    CAS No.
    97773-00-7

    (Phe2,Nle4)-ACTH (1-24) (human, bovine, rat)

    (Phe2,Nle4)-ACTH (1-24) is a synthetic fragment of the adrenocorticotropic hormone (ACTH) that targets the melanocortin receptors. This analog exhibits biological activity relevant to the study of adrenal function and stress response mechanisms. It can be utilized in various research applications, including radiolabeling with I125 at Tyr23 to create a radiolabeled ligand for biochemical assays and receptor binding studies.

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