Gene Editing & Transfection Enhancers

Cat. No.

A11098

CAS No.

503468-95-9

NU-7441 (KU-57788)

Synonyms: KU57788

NU-7441 (KU-57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor. The IC50 values are 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively.

Cat. No.

A16445

CAS No.

50-63-5

Chloroquine Phosphate

Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator.

Cat. No.

A12752

CAS No.

154447-35-5

NU7026

NU7026 is a novel DNA-dependent protein kinase inhibitor that potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia.

Cat. No.

A13224

CAS No.

881375-00-4

KU 0060648

KU0060648 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC50 = 8.6 nM); with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases. KU-0060648 enhances HDR efficiency and attenuates NHEJ frequency.

Cat. No.

A15447

CAS No.

1533426-72-0

SCR7

SCR7 is a specific DNA Ligase IV inhibitor. SCR7 inhibits end joining of double strand breaks in diverse cell types resulting in tumour regression by activation of p53 mediated apoptosis.

Cat. No.

A17055

CAS No.

1637542-33-6

Nedisertib

Synonyms: MSC2490484A; M3814

Nedisertib, also known as M-3814, MSC2490484A, is an orally available inhibitor of DNA-dependent protein kinase (DNA-PK), with potential antineoplastic and chemo/radiosensitizing activities.

Cat. No.

A17138

CAS No.

14892-97-8

SCR7 pyrazine

Synonyms: SCR-7

SCR7 pyrazine is an inhibitor of nonhomologous end-joining (NHEJ).

Cat. No.

A20049

CAS No.

2230820-11-6

AZD-7648

AZD-7648 is a potent and selective DNA-PK inhibitor. Anti-tumor activity.

Cat. No.

A24142

CAS No.

2565638-16-4

PolQi2

PolQi2 is a selective inhibitor of DNA polymerase theta (Polθ), specifically targeting its N-terminal helicase domain to suppress the alternative end-joining (alt-EJ) DNA repair pathway. By inhibiting Polθ, PolQi2 enhances the precision and integration efficiency of CRISPR/Cas9-mediated gene editing across diverse genomic loci and cell lines. Furthermore, when used in combination with DNA-PK inhibitors, PolQi2 significantly reduces off-target effects associated with Cas9 activity. These properties make PolQi2 a valuable tool for improving the fidelity and efficiency of gene editing applications in both basic research and potential therapeutic contexts.

Cat. No.

A37668

CAS No.

2607139-80-8

PolQi1

PolQi1 is a selective inhibitor of the Polθ domain of DNA polymerase, primarily targeting the Polθ-mediated microhomology end joining (TMEJ/alt-EJ) pathway. By inhibiting this pathway, PolQi1 significantly reduces insertion/deletion events and imprecise editing during DNA repair processes. This reagent enhances the efficiency and accuracy of homology-directed repair (HDR) and Prime editing, minimizing off-target effects. In combination with DNA-PK inhibitor AZD-7648, PolQi1 provides effective dual pathway regulation, making it a valuable tool for gene editing research, particularly in optimizing systems like CRISPR-Cas9 for challenging cell types such as primary hepatocytes and mouse embryos.

Cat. No.

A47968

CAS No.

895460-70-5

BRD7586

BRD7586 is a selective inhibitor of Streptococcus pyogenes Cas9 (SpCas9), demonstrating potent engagement with SpCas9 while sparing Cas12a. This compound enhances the specificity of SpCas9 at multiple genomic loci, making it a valuable tool for precision genome editing. BRD7586 inhibits SpCas9 activity across various delivery methods, supporting diverse research applications in genetic manipulation and CRISPR technology.

Cat. No.

A48036

CAS No.

1403838-79-8

BRD0539

BRD0539 is an inhibitor of Streptococcus pyogenes Cas9 (SpCas9), exhibiting an IC50 of 22 μM in vitro during DNA cleavage assays. This compound serves as a valuable tool for investigating the regulation of CRISPR-Cas9 genome editing activities. Its selective inhibition of SpCas9 enhances studies related to gene expression modulation and potential therapeutic applications in genetic engineering.

Cat. No.

A48194

CAS No.

2866499-55-8

Cas9-IN-1

Cas9-IN-1 is a potent inhibitor of Cas9, exhibiting an IC50 value of 7.02 μM. It functions by binding to apo-Cas9, thereby preventing the formation of the Cas9:gRNA complex. This mechanism makes Cas9-IN-1 valuable for research applications involving CRISPR technology, enabling studies on gene editing regulation and potential off-target effects.

Cat. No.

A48407

CAS No.

2322051-02-3

Cas9-IN-3

Cas9-IN-3 is a potent inhibitor of the Cas9 endonuclease, with an IC50 value of 28 μM. This compound is valuable for research applications focused on gene editing and CRISPR-mediated processes. By selectively inhibiting Cas9 activity, Cas9-IN-3 allows for the investigation of gene regulation and the modulation of genetic pathways in various cellular contexts.

Cat. No.

A49649

CAS No.

1030133-34-6

Cas9-IN-2

Cas9-IN-2 is a potent inhibitor of Cas9, with an IC50 of 246 μM. It functions by binding to apo-Cas9, thereby preventing the formation of the Cas9:gRNA complex. This mechanism allows for the modulation and control of Cas9 activity, making Cas9-IN-2 a valuable tool for researchers studying gene editing and its regulatory mechanisms.