Assay Controls & Cell Stimulation

Cat. No.

A12373

CAS No.

187389-52-2

Z-VAD-FMK

Synonyms: Z-VAD(OMe)-FMK

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

Cat. No.

A11043

CAS No.

133407-82-6

MG-132

Synonyms: Z-Leu-Leu-Leu-CHO; Z-LLL-CHO

MG-132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM).

Cat. No.

A10036

CAS No.

66-81-9

Cycloheximide

Synonyms: Actidione

Cycloheximide (also known as actidione) is used as an selective antibiotic. It inhibits the protein synthesis (DNA-dependent RNA) of saprobic fungi eukaryotes. by binding with the 80S ribosome, while inactive against dermatophytes and systemic fungi.

Cat. No.

A13247

CAS No.

347174-05-4

Ferrostatin-1 (Fer-1)

Synonyms: Fer1

Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM.

Cat. No.

A15865

CAS No.

1219810-16-8

RSL3

Synonyms: 1S,3R-RSL3

RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS.

Cat. No.

A13822

CAS No.

571203-78-6

Erastin

Erastin is a cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality in cells with H-Ras mutations.

Cat. No.

A14427

CAS No.

571190-30-2

Palbociclib (PD-0332991)

Synonyms: PD0332991

Palbociclib is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.

Cat. No.

A10701

CAS No.

827022-32-2

PD-0332991 HCl (Palbociclib HCl)

PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.

Cat. No.

A10864

CAS No.

62996-74-1

Staurosporine

Synonyms: AM-2282; STS

Staurosporine is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase.

Cat. No.

A14437

CAS No.

872573-93-8

Ro 3306

Ro 3306 is an ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor (Ki values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A respectively).

Cat. No.

A16445

CAS No.

50-63-5

Chloroquine Phosphate

Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator.

Cat. No.

A10669

CAS No.

579-13-5

Oligomycin A

Oligomycin A is a mitochondrial ATPase inhibitor. Oligomycin A inhibits ATP5 (mitochondrial ATPases, F1F0) bound to the cell membrane.

Cat. No.

A11973

CAS No.

4311-88-0

Necrostatin-1

Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM).

Cat. No.

A10238

CAS No.

64-86-8

Colchicine

Colchicine is an inhibitor of microtubules by specific binding to tubulin.

Cat. No.

A11961

CAS No.

88899-55-2

Bafilomycin A1

Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells.

Cat. No.

A13219

CAS No.

31430-18-9

Nocodazole

Nocodazole is a microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion.

Cat. No.

A14616

CAS No.

16561-29-8

12-O-tetradecanoyl phorbol-13-acetate

Synonyms: TPA; Phorbol 12-myristate 13-acetate

12-O-tetradecanoyl phorbol-13-acetate is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations.

Cat. No.

A20681

CAS No.

28643-80-3

Nigericin sodium salt

Synonyms: Sodium Nigericin

Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore, a NLRP3 activator.

Cat. No.

A10603

CAS No.

22373-78-0

Monensin sodium

Monensin sodium is an ionophore and inhibitor of autophagy commercially used in livestock feed. It inhibits autophagy, interfering with the fusion of the autophagosome and the lysosome.

Cat. No.

A10811

CAS No.

83-79-4

Rotenone

Rotenone is an mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

Cat. No.

A11156

CAS No.

20350-15-6

Brefeldin A

Brefeldin A blocks binding of ADP-ribosylation factor to the Golgi apparatus and inhibits GDP-GTP exchange.

Cat. No.

A13930

CAS No.

477-30-5

Demecolcine

Synonyms: NSC-3096; Kolchicin; C-12669

Demecolcine is a potent tubulin inhibitor that effectively disrupts microtubule polymerization, exhibiting an IC50 value of 2.4 μM. By binding to tubulin dimers, Demecolcine exerts anti-mitotic effects, hindering cellular division. This compound is primarily utilized in research related to inflammatory disorders and various cancer pathways, making it valuable for studies focused on cell cycle regulation and targeted therapies.

Cat. No.

A14000

CAS No.

1404-19-9

Oligomycin

Oligomycin is a macrolide that acts as a specific inhibitor of the mitochondrial ATP-synthase and blocks oxidative phosphorylation.

Cat. No.

A16340

CAS No.

161401-82-7

Z-VAD(OH)-FMK

Synonyms: Caspase Inhibitor VI

Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases.

Cat. No.

A16478

CAS No.

154-17-6

2-Deoxy-D-glucose

Synonyms: 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose

2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.