IDO

Cat. No.

A15554

CAS No.

1204669-58-8

Epacadostat (INCB024360)

Synonyms: INCB 024360

Epacadostat is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM, Phase 2,

Cat. No.

A13004

CAS No.

914471-09-3

IDO5L (INCB024360 analog)

Synonyms: INCB-024360; INCB024360 analog

INCB024360 is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase (IDO1), with potential immunomodulating and antineoplastic activities.

Cat. No.

A13507

CAS No.

77603-42-0

GNF-PF-3777

Synonyms: 8-Nitrotryptanthrin

GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.

Cat. No.

A14322

CAS No.

1402836-58-1

NLG919

NLG919 is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with potential immunomodulating and antineoplastic activities.

Cat. No.

A14397

CAS No.

110117-83-4

Indoximod (NLG-8189)

Synonyms: NLG8189; D-1MT

Indoximod is a methylated tryptophan with anti-immunosuppressive activity.

Cat. No.

A17013

CAS No.

1923833-60-6

BMS-986205

Synonyms: ONO-7701; F-001287; Linrodostat

BMS-986205, also known as Linrodostat, ONO-7701 and F001287, a potent and selective, orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities. CAS: 1923833-60-6 (free base) 2221034-29-1 (mesylate)

Cat. No.

A18566

CAS No.

2033173-01-0

IDO/TDO-IN-1

IDO/TDO-IN-1 is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively .

Cat. No.

A18988

CAS No.

1888341-29-4

IDO-IN-12

IDO-IN-12 is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO 2017181849 A1.

Cat. No.

A19372

CAS No.

1888378-32-2

IDO-IN-11

IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell), extracted from patent WO 2016041489 A1, compound 13.

Cat. No.

A19483

CAS No.

2166616-75-5

LY-3381916

LY-3381916 is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.

Cat. No.

A19647

CAS No.

1888378-12-8

IDO-IN-9

IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell), extracted from patent WO 2016041489 A1, compound 6.

Cat. No.

A20020

CAS No.

2144425-14-7

IACS-8968

Synonyms: IDO/TDO Inhibitor

IACS-8968 (IDO/TDO Inhibitor) is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and

Cat. No.

A20523

CAS No.

914638-30-5

IDO-IN-1

IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 59 nM.

Cat. No.

A20803

CAS No.

1668565-74-9

IDO-IN-2

IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1, has IC50 values of 0.068 μM in HeLa cell and 0.16 μM in HEK293 cell.

Cat. No.

A20807

CAS No.

198474-05-4

PF-06840003

Synonyms: EOS200271

PF-06840003 is a highly selective orally bioavailable IDO-1 inhibitor with IC50s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively.

Cat. No.

A20898

CAS No.

2070018-30-1

IDO-IN-3

IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 290 nM.

Cat. No.

A21074

CAS No.

1402837-79-9

IDO-IN-5

Synonyms: NLG-1489

IDO-IN-5 (NLG-1489) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1489, has an IC50 of 1-10 μM.

Cat. No.

A21077

CAS No.

1629125-65-0

BMS-978587 (IDO-IN-4)

Synonyms: IDO-IN-4

IDO-IN-4 is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1.

Cat. No.

A21555

CAS No.

2239305-67-8

IACS-8968 R-enantiomer

Synonyms: IDO/TDO Inhibitor (R-enantiomer); IACS8968

IACS-8968 (R-enantiomer) is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and

Cat. No.

A21559

CAS No.

2239305-70-3

IACS-8968 S-enantiomer

Synonyms: IDO/TDO Inhibitor (S-enantiomer); IACS8968

IACS-8968 (S-enantiomer) is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and

Cat. No.

A22549

CAS No.

1402837-78-8

Navoximod free base

Synonyms: Navoximod; IDO-IN-7; Navoximod Phosphate; NLG-1488; NLG1488.

Navoximod, also known as IDO-IN-7 and NLG-1488, is an indoleamine 2,3-dioxygenase (IDO) inhibitor.

Cat. No.

A22587

CAS No.

2291164-02-6

IDO-IN-13

Synonyms: GS-4361

IDO-IN-13 is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an EC50 of 17 nM, extracted from patent WO2019040102A1, example 43.

Cat. No.

A24609

CAS No.

163239-22-3

680C91

680C91 is a selective inhibitor of tryptophan 2,3-dioxygenase (TDO), exhibiting a potent Ki of 51 nM. By targeting TDO, a crucial enzyme in tryptophan catabolism, 680C91 plays a significant role in modulating tryptophan metabolism. This reagent is particularly valuable in the exploration of cancer immunotherapy and Alzheimer’s disease research applications.

Cat. No.

A26470

CAS No.

2227044-16-6

IDO1 and HDAC1 Inhibitor

IDO1 and HDAC1 Inhibitor (Compound 10) is a dual-target inhibitor that effectively inhibits indoleamine 2,3-dioxygenase 1 (IDO1) and histone deacetylase 1 (HDAC1) with IC50 values of 69.0 nM and 66.5 nM, respectively. This compound demonstrates significant biological activity in modulating immune responses and epigenetic regulation. It is suitable for use in cancer research, immunotherapy studies, and investigations into the mechanistic roles of IDO1 and HDAC1 in various biological processes.

Cat. No.

A30342

CAS No.

26988-72-7

(Rac)-Indoximod

Synonyms: 1-Methyl-DL-tryptophan; (Rac)-NLG-8189

(Rac)-Indoximod is an indoleamine 2,3-dioxygenase (IDO) inhibitor that modulates immune responses. This compound synergizes with interferon-gamma (IFN-γ) to significantly decrease the activity of human cardiac myofibroblasts, characterized by α-SMA expression, and promotes apoptosis by upregulating the genes IRF-1, Fas, and FasL. Its applications include studying immune regulation and apoptosis in cardiac tissue and investigating therapeutic strategies for fibrotic diseases.