Integrin

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  1. Zaurategrast (CDP323)

    Catalog No. A11614
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    VCAM-1 antagonist
    CDP323 is a small-molecule prodrug antagonist of the vascular cell adhesion molecule 1 binding to ??4-integrins Learn More
  2. Obtustatin

    Catalog No. A17185
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    α1β1 inhibitor
    Highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma; blocks human melanoma growth in nude mice. Learn More
  3. TCS2314

    Catalog No. A17193
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    Integrin Inhibitor
    TCS2314 is a integrin very late antigen-4 (VLA-4; α4β1) antagonist with IC50 value of 4.4 nM. Learn More
  4. BTT-3033

    Catalog No. A17200
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    α2β1 integrin inhibitor
    BTT-3033 is a α2β1 integrin inhibitor. Learn More
  5. BOP sodium salt

    Catalog No. A17201
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    α9β1/α4β1 integrin inhibitor
    BOP sodium salt is a novel dual alpha9beta1/alpha4beta1 integrin inhibitor. Learn More
  6. BIO-1211

    Catalog No. A17210
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    Integrin alpha4beta1 inhibitor
    BIO-1211 is an integrin alpha4beta1 inhibitor. Learn More
    • New

    TR-14035

    Catalog No. A17118
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    Integrin Antagonist
    TR-14035 is a dual antagonist of α4β7 and α4β1 integrins. Learn More
  7. A-205804

    Catalog No. A13047
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    Integrin Inhibitor
    A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC50 value of 20 nM and 25 nM, respectively. Learn More
  8. CWHM12

    Catalog No. A15967
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    αV integrins inhibitor
    CWHM 12 can suppress all 5 alpha V integrins. CWHM12 not only worked the same way to prevent fibrosis as the genetic deletion method, it also prevent the progression of existing fibrosis in the liver and lungs and reversed some of the damage caused by fibrosis to those organs. Learn More
  9. Cyclo(RGDyK)

    Catalog No. A15918
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    Integrin inhibitor
    Cyclo(RGDyK) is a potent and selective alphaVbeta3 integrin inhibitor with IC50 of 20 nM. Learn More
  10. E7820

    Catalog No. A15456
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    lpha-2-integrin inhibitor
    E7820 is a small molecule and aromatic sulfonamide derivative with potential antiangiogenic and antitumor activities. E7820 inhibits angiogenesis by suppressing integrin alpha 2, a cell adhesion molecule expressed on endothelial cells. Learn More
  11. RGD (Arg-Gly-Asp) Peptides

    Catalog No. A15538
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    Inhibits integrin binding to RGD motifs
    RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins. Learn More
  12. Cyclo (-RGDfK)

    Catalog No. A14923
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    αvβ3 integrin inhibitor
    Cyclo (-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin. Learn More
  13. Leukadherin 1

    Catalog No. A13968
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    Integrin agonist
    Leukadherin 1 is an allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50 = 4 μM). Learn More
  14. Pyrintegrin

    Catalog No. A12876
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    Pyrintegrin is a cell-permeable small molecule that promotes human embryonic stem cell (hESC) survival by > 30-fold. Learn More
  15. Firategrast (SB 683699)

    Catalog No. A12787
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    α4β1/α4β7 integrin antagonist
    Firategrast is an orally bioavailable alpha4 beta1/alpha4 beta7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS). Learn More
  16. Cilengitide trifluoroacetate

    Catalog No. A12371
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    Integrin inhibitor
    Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. Learn More
  17. Cilengitide

    Catalog No. A12372
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    Integrin inhibitor
    Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. Learn More
  18. R-BC154

    Catalog No. A17184
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    α4β1/α9β1 inhibitor
    R-BC154 is a high affinity fluorescent α4β1/α9β1 inhibitor. Learn More

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