IRAK

Interleukin-1 receptor-associated kinases (IRAKs) are key components in the signal transduction pathways utilized by interleukin-1 receptor (IL-1R), interleukin-18 receptor (IL-18R), and Toll-like receptors (TLRs).

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  1. JNK-IN-7

    Catalog No. A15136
    JNK Inhibitor
    JNK-IN-7 is a relatively selective JNKs inhibitor(IC50= 1.54/1.99/0.75 for JNK1/2/3); also bound to IRAK1, PIK3C3, PIP5K3 and PIP4K2C. Learn More
  2. IRAK-1-4 Inhibitor I

    Catalog No. A11462
    IRAK-1-4 inhibitor is a benzimidazole that disrupts the activity of IRAK-1 and -4 with IC50 values of 300 and 200 nM, respectively. Learn More
  3. IRAK inhibitor
    IRAK-IN-6, also known as IRAK inhibitor 6, is an interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor. IRAK-4 is reported to be essential for the activation of the intracellular signalling cascades including NF-kB and MAPK pathways, which are critical for the production of inflammatory cytokines. Learn More
  4. CA-4948

    Catalog No. A17005
    IRAK4 inhibitor
    CA-4948 is a potent, and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor. CA-4948 exhibited the greatest efficacy in four of the five ABC-DLBCL PDX models tested as compared to GBC-DLBCL and ABC/GCB DLBCL PDX models. Learn More
  5. PF-06650833

    Catalog No. A17187
    IRAK4 inhibitor
    PF-06650833 is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4). Learn More
  6. AS 2444697

    Catalog No. A17186
    IRAK4 inhibitor
    AS-2444697 is a potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with IC50 value of 21 nM. Learn More

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