Chelators & Bifunctional Chelators

Cat. No.

A88181

CAS No.

150-39-0

EDTA-OH

EDTA-OH is a powerful chelating agent that targets various metal ions, including calcium, magnesium, iron, zinc, and copper, forming stable thermodynamic complexes. This reagent is particularly relevant in research applications focused on phytoremediation of heavy metal-contaminated soils, assisting in the detoxification process. Additionally, EDTA-OH demonstrates the ability to cross the blood-brain barrier, making it a valuable tool for studies related to neurological research and metal ion interactions in biological systems.

Cat. No.

A88201

CAS No.

181065-46-3

p-NH2-Bn-DOTA

p-NH2-Bn-DOTA is a bifunctional chelator (BFC) and a macrocyclic derivative of DOTA, designed for tumor pre-targeting applications. This compound facilitates the conjugation of peptides and radionuclides, enabling efficient delivery systems in targeted radiotherapy. Its ability to form stable complexes enhances its utility in various biological research applications, particularly in the field of cancer treatment and diagnosis.

Cat. No.

A88497

CAS No.

303136-82-5

Neocuproine hydrochloride monohydrate, 99%

Neocuproine hydrochloride monohydrate is a metal chelator that specifically targets copper ions. This compound is widely used in research to assess antioxidant capacity in biological samples through the formation of copper reduction complexes. Its application extends to studies exploring oxidative stress, metal ion interactions, and related biochemical pathways.

Cat. No.

A88766

CAS No.

2097123-80-1

HBED-CC-tris(tert-butyl ester)

HBED-CC-tris(tert-butyl ester) is a bifunctional chelating agent that targets metal ions for effective chelation. This compound is primarily utilized in radiolabeling studies and aids in the development of compounds for tumor-assisted imaging and diagnostics. Its unique structure enhances the stability and binding efficiency of radiometals, making it valuable for oncology research applications.

Cat. No.

A88828

CAS No.

2236057-47-7

DOTAM-NHS-ester

DOTAM-NHS-ester is a bifunctional chelator (BFC) and a macrocyclic derivative of DOTA, primarily utilized for tumor pre-targeting applications. This reagent facilitates the conjugation of peptides and radionuclides, enabling the development of targeted diagnostic and therapeutic strategies in cancer research. Its unique properties make it an essential tool for bioconjugation studies and radiolabeled biomolecule design.

Cat. No.

A88935

CAS No.

753421-63-5

4-Aminobutyl-DOTA

4-Aminobutyl-DOTA is a bifunctional chelator that functions as a macrocyclic DOTA derivative. It is primarily utilized for tumor pre-targeting applications, enabling the conjugation of peptides and radionuclides. This compound facilitates enhanced imaging or therapeutic delivery in cancer research, providing a versatile tool for the development of targeted therapies.

Cat. No.

A88977

CAS No.

58105-91-2

Hexacyclen hexahydrochloride

Synonyms: Hexaaza-18-crown-6 hexahydrochloride; 1,4,7,10,13,16-Hexaazacyclooctadecane hexahydrochloride

Hexacyclen hexahydrochloride is a chelating agent that features a macrocyclic structure composed of six nitrogen-containing rings. This compound effectively binds metal ions, making it valuable for research applications involving the study of protein and enzyme structure and function. Additionally, Hexacyclen hexahydrochloride has been identified as an inhibitor of cancer, further expanding its utility in biochemical research and therapeutic exploration.

Cat. No.

A89031

CAS No.

585531-74-4

BFCAs-1

BFCAs-1 is a bifunctional chelating agent that selectively binds metal ions for applications in medical imaging and biochemistry. This compound facilitates the complexation of radionuclides and metal-based therapeutics, enhancing imaging contrast and therapeutic efficacy. Its unique properties make it a valuable tool for researchers in the fields of molecular imaging and targeted drug delivery.

Cat. No.

A89132

CAS No.

14098-44-3

Benzo-15-crown-5-ether

Synonyms: B15C5

Benzo-15-crown-5-ether functions as a chelating agent with a high affinity for monovalent cations, particularly sodium and potassium ions. Its ability to selectively bind these metal ions makes it valuable in a variety of research applications, including ion-selective electrodes and the study of ion transport mechanisms. This compound is widely used in analytical chemistry and biochemical research to facilitate precise measurements of ionic species in various environments.

Cat. No.

A89279

CAS No.

13235-36-4

EDTA tetrasodium tetrahydrate

Synonyms: Ethylenediaminetetraacetic acid tetrasodium tetrahydrate

EDTA tetrasodium tetrahydrate is a potent metal chelator that effectively binds divalent and trivalent metal cations, including calcium. This compound exhibits anticoagulant properties and demonstrates anti-hypercalcemic activity, making it valuable in various biological research applications. Additionally, EDTA tetrasodium tetrahydrate reduces metal ion-catalyzed oxidative damage to proteins and helps maintain a reducing environment during protein purification, while also minimizing the formation of disulfide bonds.

Cat. No.

A89341

CAS No.

175854-39-4

Tris-BOC-cyclen

Tris-BOC-cyclen is a bifunctional chelator designed to effectively coordinate radiometals. This compound enables stable linkage of radiometals to carrier moieties in radiopharmaceuticals, enhancing their efficacy and specificity. It is applicable in the development of targeted imaging agents and therapeutic agents for oncology research, contributing to advancements in nuclear medicine.

Cat. No.

A89526

CAS No.

13291-61-7

trans-1,2-Cyclohexanediaminetetraacetic acid

Trans-1,2-Cyclohexanediaminetetraacetic acid (trans-CHDTA) functions as a powerful chelator of heavy metal ions through the formation of stable complexes. It exhibits high affinity for various metal ions, making it valuable in applications such as environmental detoxification and biochemical research involving metal ion dynamics. This compound is essential for studies focused on heavy metal remediation, ion transport mechanisms, and metal ion speciation.

Cat. No.

A89547

CAS No.

31249-95-3

Diaza-15-crown-5

Diaza-15-crown-5 serves as a chelator that modifies the surface charge of bacteriorhodopsin (BR) membranes. This crown ether compound significantly extends the lifetime of M intermediates within these membranes, contributing to enhanced membrane stability. Its unique properties make it valuable for research applications focused on studying phototransduction processes and membrane dynamics.

Cat. No.

A89575

CAS No.

205986-41-0

p-NH₂-Bn-DTPA-penta (t-Bu ester)

p-NH₂-Bn-DTPA-penta (t-Bu ester) is a bifunctional chelator designed for targeted applications in tumor pre-targeting. This macrocyclic DTPA derivative facilitates the conjugation of peptides and radionuclides, enhancing the specificity and efficacy of radiotherapy. Its unique structure allows for efficient binding and release, making it a valuable tool in bioconjugation studies and radiopharmaceutical development.

Cat. No.

A89712

CAS No.

1421584-86-2

Triplin

Triplin is a copper chelator that disrupts copper ion transport, specifically affecting the interaction between RAN1 and ATX1. This compound mitigates the detrimental impact of excess copper on plant root development and enhances the RNA expression of the ethylene response factor ERF1. Additionally, Triplin functions as a bacterial pore-former, making it a valuable tool in studies of copper homeostasis and ethylene signaling pathways.

Cat. No.

A89855

CAS No.

1402393-59-2

4-Aminobutyl-DOTA-tris(t-butyl ester)

4-Aminobutyl-DOTA-tris(t-butyl ester) is a bifunctional chelator (BFC) and a macrocyclic DOTA derivative designed for tumor pre-targeting applications. This compound facilitates the conjugation of peptides and radionuclides, enabling enhanced imaging and therapeutic strategies in research. Its unique structure allows for improved stability and targeting capabilities, making it valuable in the development of targeted radiopharmaceuticals.

Cat. No.

A90138

CAS No.

217973-03-0

DO3A trisodium

DO3A trisodium is a bifunctional chelator (BFC) and a macrocyclic derivative of DOTA, primarily utilized for tumor pre-targeting applications. This reagent enables efficient conjugation of peptides and radionuclides, facilitating targeted delivery in cancer research. Its chelating properties make it ideal for studies focused on radiolabeling and tracer development in various therapeutic and diagnostic applications.

Cat. No.

A90324

CAS No.

172646-47-8

5,5'-Dinitro BAPTA AM

5,5'-Dinitro BAPTA AM is a membrane-permeant calcium chelator that effectively binds to cytosolic Ca2+. This compound is utilized for probing the role of calcium ions in various cellular processes. Upon incubation with live cells, 5,5'-Dinitro BAPTA AM is hydrolyzed by cytosolic esterases, releasing the active tetra-carboxylate ligand for further biological investigation.

Cat. No.

A90476

CAS No.

254444-71-8

DOTA-4AMP

DOTA-4AMP is a bifunctional chelator (BFC) primarily designed for tumor pre-targeting applications. As a macrocyclic derivative of DOTA, it facilitates the efficient conjugation of peptides and radionuclides. DOTA-4AMP is invaluable in oncology research, enabling precise localization of therapeutic agents and improving the efficacy of targeted cancer therapies.

Cat. No.

A90506

CAS No.

105613-48-7

Exametazime

Synonyms: HM-PAO

Exametazime (HM-PAO) serves as a lipophilic chelating agent primarily utilized in the preparation of radiopharmaceuticals for brain imaging. This compound is particularly recognized for its efficacy in in vitro leukocyte labeling, enhancing the visualization and assessment of various neurological conditions in clinical and research settings.

Cat. No.

A90631

CAS No.

2125661-90-5

p-NH2-Bn-oxo-DO3A

p-NH2-Bn-oxo-DO3A is a bifunctional chelator (BFC) that acts as a macrocyclic DOTA derivative, specifically designed for tumor pre-targeting applications. This compound facilitates the conjugation of peptides and radionuclides, enhancing targeted delivery and imaging capabilities in cancer research. Its unique structure allows for effective integration into various therapeutic and diagnostic modalities.

Cat. No.

A90655

CAS No.

116052-88-1

p-NO2-Bn-DOTA

p-NO2-Bn-DOTA is a bifunctional chelator (BFC) and a macrocyclic DOTA derivative, primarily utilized for tumor pre-targeting applications. This compound facilitates the conjugation of peptides and radionuclides, enhancing targeted delivery in cancer research. Its unique structure supports the development of advanced imaging and therapeutic strategies in oncology.

Cat. No.

A90768

CAS No.

148408-89-3

(R)-tetraMe-Tetraxetan

Synonyms: (R)-tetraMe-DOTA

(R)-tetraMe-Tetraxetan is a bifunctional chelator (BFC) and a macrocyclic derivative of DOTA, designed for tumor pre-targeting applications. This compound facilitates the selective conjugation of peptides and radionuclides, enhancing the efficiency of targeted imaging and therapy. Its unique structure allows for improved binding characteristics, making it a valuable tool in cancer research and the development of radiopharmaceuticals.

Cat. No.

A90989

CAS No.

162148-45-0

Bis-Cbz-cyclen

Bis-Cbz-cyclen is a bifunctional chelator that effectively forms stable complexes with radiometals, facilitating their incorporation into radiopharmaceutical carrier moieties. This compound is primarily utilized in the development of targeted radiolabeled molecules for imaging and therapeutic applications in nuclear medicine. Its chelation properties make it an essential tool for researchers in radiochemistry and molecular imaging studies.

Cat. No.

A91109

CAS No.

147504-94-7

MAPTAM

MAPTAM is an intracellular calcium (Ca2+) chelator that effectively sequesters free calcium ions within cells. It is utilized in research to study calcium signaling pathways and to investigate the role of intracellular calcium in various cellular processes. MAPTAM is valuable for exploring the impact of altered calcium homeostasis on cell function and pathology.