Chelators & Bifunctional Chelators

Cat. No.

A86384

CAS No.

67-42-5

EGTA

EGTA is a highly specific calcium ion chelator that operates by binding calcium ions with an apparent dissociation constant (Kd) of 60.5 nM at physiological pH (7.4). Its strong selectivity for Ca2+ over Mg2+ (with a Kd for Mg2+ ranging from 1-10 mM) makes it particularly valuable in research involving calcium signaling. EGTA is effective in inhibiting the substrate adherence capacity of inflammatory macrophages, making it useful in studying inflammatory responses and various cellular processes.

Cat. No.

A86446

CAS No.

99590-86-0

EGTA-AM

Synonyms: EGTA Acetoxymethyl ester

EGTA-AM is a membrane-permeable calcium (Ca2+) chelator that facilitates passive loading into cells, providing intracellular chelation of calcium ions. This compound exhibits slow chelating dynamics, making it suitable for experiments requiring sustained modulation of intracellular calcium levels. EGTA-AM is widely used in studies of cellular signaling, muscle contraction, and neuronal activity, where precise control of Ca2+ concentration is crucial for understanding various physiological processes.

Cat. No.

A86592

CAS No.

23978-09-8

Cryptand 2.2.2

Synonyms: 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane

Cryptand 2.2.2 is an ion chelator that selectively forms complexes with transition metal ions including Zn2+, Co2+, Ni2+, and Cu2+. Its structural properties enable it to act as a host molecule, exhibiting strong chelation effects at room temperature. This compound is widely used in applications such as nanoparticle synthesis and the preparation of transition metal complexes in various chemical research contexts.

Cat. No.

A86593

CAS No.

16448-54-7

Ferric nitrilotriacetate

Ferric nitrilotriacetate (Fe-NTA) acts as an iron chelator, involved in promoting oxidative stress. Its biological activity has been leveraged to induce degenerative disorders, including hyperglycemia and glycosuria, while serving as a model for renal and liver carcinogenesis studies. This compound is valuable for research applications focused on mechanisms underlying oxidative damage and associated disease processes.

Cat. No.

A86720

CAS No.

482-54-2

1,2-Cyclohexylenedinitrilotetraacetic acid

Synonyms: CDTA

1,2-Cyclohexylenedinitrilotetraacetic acid (CDTA) functions as a chelating agent that selectively binds to metal ions, effectively removing manganese from biological systems. This compound has demonstrated significant efficacy in vivo and in vitro, particularly in reducing manganese levels in the brain and liver of rats pretreated with manganese sulfate. CDTA is a valuable tool for research focused on metal ion metabolism and toxicity, as well as potential therapeutic applications in conditions associated with manganese overload.

Cat. No.

A86735

CAS No.

294-90-6

Cyclen

Cyclen is a macrocyclic tetraamine chelating agent known for its specific coordination properties towards lithium ions. It serves as a precursor for magnetic resonance imaging (MRI) contrast agents and plays a crucial role in the synthesis of effective macrocyclic chelates. Additionally, Cyclen facilitates the development of polyamide nanofiltration membranes by acting as a structural regulator in the interfacial polymerization of polyethyleneimine and trimesoyl chloride, enhancing lithium and magnesium ion separation efficiency. Its unique cavity structure allows for selective ion binding, making it valuable in various research applications.

Cat. No.

A86784

CAS No.

819869-77-7

DOTA-tris(tBu)ester NHS ester

DOTA-tris(tBu)ester NHS ester is a bifunctional chelator that facilitates the conjugation to primary amines in proteins, amine-modified oligonucleotides, and other amine-containing compounds. Following deprotection, it forms stable complexes with metal ions, enabling its use in various molecular imaging applications. This reagent is essential for researchers focused on the development of targeted imaging agents and radiopharmaceuticals.

Cat. No.

A86791

CAS No.

35369-53-0

HBED dihydrochloride

HBED dihydrochloride is a hexadentate iron chelator targeting iron ion complexes. Its structure, N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid, facilitates the effective excretion of iron in primate models. This compound offers promising applications in iron chelation therapy, presenting an alternative strategy for managing iron overload conditions.

Cat. No.

A86927

CAS No.

13368-13-3

EGTA tetrasodium

EGTA tetrasodium is a specialized calcium ion chelator with a primary mechanism of chelating Ca2+ ions. It exhibits a low apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4), demonstrating high specificity for calcium over magnesium (Kd for Mg2+ is 1-10 mM). This compound is utilized in research applications focusing on calcium-dependent cellular processes, including the inhibition of substrate adherence in inflammatory macrophages.

Cat. No.

A87091

CAS No.

2194580-71-5

p-NCS-Bz-DOTA-GA

p-NCS-Bz-DOTA-GA is a bifunctional chelator that serves as a versatile linker for targeted molecular imaging. It effectively facilitates the conjugation of imaging agents for both positron emission tomography (PET), single-photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI) applications. This compound enables enhanced visualization of specific biomolecules, promoting advancements in diagnostic and therapeutic research.

Cat. No.

A87102

CAS No.

52-66-4

DL-Penicillamine

Synonyms: (±)-Penicillamine

DL-Penicillamine is a copper chelating agent utilized in the treatment of conditions related to copper overload. It exhibits antidotal properties in thallotoxicosis and can mitigate toxicity when used alongside Prussian blue. While effective, DL-Penicillamine is also associated with potential side effects, such as inducing pyridoxine deficiency and optic axial neuritis, as well as the suppression of the primary immune response. This compound serves as a valuable tool in research applications focused on metal ion interactions and immune system modulation.

Cat. No.

A87183

CAS No.

295-37-4

Cyclam

Cyclam is a metal chelator that efficiently forms complexes with various metal ions. These metal complexes demonstrate significant biological activities, including anti-HIV effects, nitric oxide (NO) releasing and scavenging properties, as well as superoxide dismutase (SOD) mimetic activity. Cyclam and its metal complexes, such as Zn(II)-Cyclam and Mn(III)-Cyclam, are valuable tools for research in virology, oxidative stress, and metal ion regulation.

Cat. No.

A87253

CAS No.

1020407-41-3

(S)-p-SCN-Bn-DOTA

(S)-p-SCN-Bn-DOTA is a bifunctional chelator (BFC) that acts as a macrocyclic DOTA derivative, facilitating effective tumor pretargeting. This compound is designed for conjugating peptides and radionuclides, serving as a linker for In-111 labeled radioimmunoconjugates (RICs) utilized in single photon emission tomography (SPECT) and in vitro biodistribution studies. Its utility in radiolabeling applications enhances the development of targeted imaging agents in cancer research.

Cat. No.

A87284

CAS No.

79-40-3

Dithiooxamide

Dithiooxamide, a selective chelating agent, acts primarily through the formation of stable complexes with various metal ions, including lead, iron, cadmium, manganese, and aluminum. This compound is utilized in environmental and analytical chemistry for the separation, enrichment, and detection of these metal ions on solid adsorbents or electrode surfaces. Its ability to selectively bind metal ions makes it a valuable reagent in studies involving metal analysis and remediation.

Cat. No.

A87295

CAS No.

82461-57-2

LK 614

LK 614 is a membrane-permeable iron chelator that targets ferrous iron influx within cells. It is utilized to investigate the protective effects against L-Histidine-induced cytotoxicity, making it a valuable tool for studying iron homeostasis and oxidative stress in various biological models. Researchers can leverage LK 614 to elucidate the interplay between iron dysregulation and cellular damage, contributing to a deeper understanding of iron-related disorders.

Cat. No.

A87438

CAS No.

869-52-3

TTHA

TTHA is an aminopolycarboxylic acid chelating agent with a preferential affinity for lighter rare earth element (REE) ions. It functions primarily through chelation, effectively binding to REE ions and facilitating their separation and analysis. TTHA is valuable in a range of research applications, including environmental studies and materials science, where precise control of metal ions is essential.

Cat. No.

A87508

CAS No.

20846-91-7

(S,S)-EDDS

(S,S)-EDDS is a metal chelator that effectively binds to various metal ions. This stereoisomer of EDTA demonstrates strong biodegradability, making it suitable for applications in environmental management and biotechnology. Its metal-binding properties enable its use in remediation processes and the development of environmentally friendly formulations.

Cat. No.

A87554

CAS No.

865470-67-3

DOTA-Thiol

DOTA-Thiol is a bifunctional chelator (BFC) and a macrocyclic derivative of DOTA, designed for tumor pre-targeting applications. This compound facilitates the conjugation of peptides and radionuclides, enabling enhanced imaging and targeted radiotherapy in cancer research. Its unique chemical properties make it an essential tool for investigations focused on targeted delivery and diagnostic applications in oncology.

Cat. No.

A87614

CAS No.

85715-60-2

EDTA hydrate sodium

Synonyms: Ethylenediaminetetraacetic acid hydrate sodium

EDTA hydrate sodium, a metal chelator, effectively binds to bivalent and trivalent metal cations, including calcium. This compound exhibits diverse biological activities such as antibacterial, anti-inflammatory, antioxidant, and anticoagulant properties. It is instrumental in reducing metal ion-catalyzed oxidative damage to proteins, facilitating a reducing environment essential for protein purification. Additionally, EDTA hydrate sodium shows potential in alleviating liver fibrosis and is utilized in research pertaining to coronary artery disease and neurological disorders.

Cat. No.

A87812

CAS No.

162148-48-3

DO2A-tert-butyl ester

DO2A-tert-butyl ester is a bifunctional chelator that facilitates the coupling of peptides to radionuclides. This compound is essential for the design and development of radionuclide imaging tracers, enabling enhanced visualization in various biological applications. Its capacity to form stable complexes with metal ions makes it a valuable tool in radiolabeling and nuclear medicine research.

Cat. No.

A87824

CAS No.

102650-30-6

Bz-DTPA

Bz-DTPA is a bifunctional chelator that plays a critical role in radiolabeling applications. It is specifically employed for the preparation of immunoconjugates, facilitating the labeling of monoclonal antibodies, such as 2G3, with indium-111. This compound enhances the stability and efficacy of radiolabeled antibodies for use in targeted imaging and therapeutic strategies in cancer research.

Cat. No.

A88126

CAS No.

479081-06-6

Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)

Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester) is a bifunctional chelator (BFC) that serves as a macrocyclic DOTA derivative, primarily utilized for tumor pre-targeting applications. This reagent facilitates the conjugation of peptides and radionuclides, enhancing the specificity and efficacy of imaging and therapeutic strategies in cancer research. Its unique structural properties make it a valuable tool for developing targeted radiopharmaceuticals.

Cat. No.

A88139

CAS No.

91987-74-5

DOTMP

DOTMP is a bifunctional chelator known for its ability to stably bind radiometals to carrier molecules in radiopharmaceutical applications. Its chelating properties enable efficient complexation and improve the overall stability of radiolabeled compounds. DOTMP is a valuable reagent in the development of diagnostic and therapeutic agents for medical imaging and targeted radiotherapy.

Cat. No.

A88140

CAS No.

282097-63-6

p-SCN-Bn-TCMC

p-SCN-Bn-TCMC is a bifunctional chelator characterized by its cyclen backbone, which effectively binds Hg2+. The isothiocyanate group facilitates conjugation to various biomolecules, enhancing its versatility in chemical applications. This reagent is particularly relevant for research in prostate cancer, enabling targeted delivery and tracking of therapeutic agents or imaging compounds.

Cat. No.

A88148

CAS No.

157599-02-5

DOTA-amide

DOTA-amide is a bifunctional chelator (BFC) and a macrocyclic DOTA derivative designed for tumor pre-targeting applications. This compound facilitates the conjugation of peptides and radionuclides, enhancing specific localization and delivery in targeted therapies. Its capability to form stable complexes with various therapeutic agents makes DOTA-amide a valuable tool in cancer research and therapeutic development.