Chelators & Bifunctional Chelators

Cat. No.

A41685

CAS No.

180152-82-3

Maleimide-DTPA

Synonyms: MDTPA

Maleimide-DTPA is a bifunctional chelator that enables the conjugation of peptides with radionuclides for targeted imaging and therapeutic applications. The maleimide group allows for selective attachment to thiol-containing biomolecules, facilitating the stable chelation of indium-111 (111In). This compound demonstrates high stability when complexed with peptides in biological environments, making it a valuable tool for medical imaging and development of radionuclide conjugates. Its utility in peptide labeling enhances research in nuclear medicine and targeted radiotherapy.

Cat. No.

A41686

CAS No.

3053227-80-5

NH2-NODAGA TFA

NH2-NODAGA TFA is a bifunctional chelator designed for the coordination of radionuclides, facilitating the development of radionuclide conjugates (RDCs). It can be reacted with diethyl squarate in a 0.5M phosphate buffer at room temperature, yielding NODAGA.SA, which effectively targets the L-lysine urea-L-glutamate (KuE) moiety associated with prostate-specific membrane antigen (PSMA). The complex NODAGA.SA.KuE demonstrates the ability to bind [68]Ga, making it valuable for positron emission tomography (PET) imaging in research involving NMRInu/nu nude mice with LNCaP tumors.

Cat. No.

A41692

CAS No.

180152-83-4

DTPA-tetra(tBu)ester

DTPA-tetra(tBu)ester is a bifunctional chelator that effectively forms stable complexes with radionuclides. This compound is utilized in various applications, including targeted medical imaging and therapeutic strategies, due to its ability to selectively bind biomolecules. Its properties make it valuable for research in the fields of radiopharmaceutical development and molecular imaging.

Cat. No.

A41696

CAS No.

827331-42-0

THP(Bz)3-NH2

THP(Bz)3-NH2 is a bifunctional chelator that exhibits the capability to form stable complexes with radionuclides. This compound is designed for applications in targeted medical imaging and therapeutic modalities, allowing for specific interaction with biomolecules. Its effective binding properties make it a valuable tool in the development of radionuclide conjugates for research in radiochemistry and molecular imaging.

Cat. No.

A41698

CAS No.

2306108-46-1

NH2-PEG4-NODA-GA

NH2-PEG4-NODA-GA is a bifunctional chelator that features the NODA moiety, enabling effective binding to various radionuclides. This compound is instrumental in the development of radionuclide drug conjugates (RDCs), which can selectively target specific biomolecules for applications in medical imaging and targeted therapy. Its design facilitates enhanced stability and functionality, making it a valuable tool in radiopharmaceutical research.

Cat. No.

A41701

CAS No.

133256-65-2

NOTA trihydrochloride

NOTA trihydrochloride is a bifunctional chelator (BFC) that serves as a macrocyclic derivative of NOTA designed for tumor pre-targeting applications. This compound facilitates the conjugation of peptides and radionuclides, making it a valuable tool in cancer research and diagnostic imaging. Its ability to form stable complexes enhances its utility in various bioconjugation strategies, particularly in the development of targeted therapies.

Cat. No.

A41706

CAS No.

23911-26-4

DTPA anhydride

DTPA anhydride is a bifunctional chelator that effectively reacts with amino groups, particularly lysine residues, in proteins to form stable amide bonds. This compound also facilitates the binding of radionuclides for the synthesis of radionuclide-labeled drug conjugates (RDCs). RDCs are designed for specific targeting of biomolecules, making them valuable tools in medical imaging and therapeutic applications.

Cat. No.

A41708

CAS No.

1374994-81-6

NCS-MP-NODA

Synonyms: NODA-Bz-SCN

NCS-MP-NODA (NODA-Bz-SCN) is a bifunctional chelator designed to specifically bind to the labeled peptide DK222, targeting PD-L1 with high affinity. This reagent facilitates the synthesis of fluorinated radioactive analogs, such as [18/19F]DK222, using the aluminum fluoride method. [18F]DK222 enables in vivo quantification of PD-L1 expression through PET imaging in various xenograft cancer models, making it a valuable tool for cancer research and immunotherapy studies.

Cat. No.

A41709

CAS No.

913542-71-9

DOTA-bis(tert-butyl)ester

DOTA-bis(tert-butyl)ester serves as a bifunctional chelator that facilitates the binding of radionuclides, making it essential for the preparation of radionuclide conjugates (RDCs). It can be conjugated with various salts to yield different metal chelators, such as DOTA-MN2, which can be radiolabeled with [67]Ga-citrate. In biological studies, [(67)Ga-DOTA-MN2] demonstrates stability in phosphate buffer solution and mouse plasma over a 24-hour period, exhibiting high tumor uptake and rapid plasma clearance in NFSa tumor models. This compound is a valuable tool for SPECT and PET imaging applications.

Cat. No.

A41710

CAS No.

2716184-56-2

Guraxetan-NH-PEG3-TFP ester

Guraxetan-NH-PEG3-TFP ester is a chelating agent-linker conjugate utilized in the synthesis of radiopharmaceuticals. This compound facilitates the attachment of metal ions for imaging applications, promoting targeted delivery and enhancing the specificity of tracers in molecular imaging studies. Its unique structure allows for effective conjugation to biomolecules, making it a valuable tool in the development of novel therapeutic and diagnostic agents.

Cat. No.

A42410

CAS No.

34441-14-0

Nicotianamine

Nicotianamine is an iron-chelating agent that plays a crucial role in metal nutrition and homeostasis in flowering plants. It serves as a key biosynthetic precursor for phytosiderophores, facilitating iron transport within the plant. Additionally, nicotianamine exhibits angiotensin-converting enzyme (ACE) inhibitory activity, with IC50 values of 76 nM and 59 nM for recombinant human ACE2 and ACE, respectively. This compound is valuable for research investigating iron metabolism and the physiological effects of metal ions in plants.

Cat. No.

A43724

CAS No.

83104-85-2

Quin-2AM

Synonyms: Quin-2 acetoxymethyl ester

Quin-2AM is a fluorescent calcium chelator designed to detect intracellular calcium ions with high affinity and specificity. This compound exhibits excellent sensitivity and low cytotoxicity, making it suitable for live-cell imaging. Upon entering the cell through the enhanced acetylmethyl ester form, Quin-2AM is cleaved by intracellular esterases, allowing it to effectively bind calcium ions and emit strong fluorescence, thereby facilitating quantitative studies in calcium signaling and related biological processes.

Cat. No.

A43839

CAS No.

73630-09-8

5,5'-Dimethyl BAPTA tetrapotassium

5,5'-Dimethyl BAPTA tetrapotassium is a water-soluble extracellular metal chelator primarily targeting calcium ions. This compound exhibits relative selectivity in binding calcium, making it useful for studies investigating calcium-dependent processes and signaling pathways. Its ability to effectively chelate divalent metal ions aids in elucidating the roles of calcium in various biological systems and experimental models.

Cat. No.

A43840

CAS No.

73630-11-2

5,5'-Dibromo BAPTA tetrapotassium

5,5'-Dibromo BAPTA tetrapotassium is a potent calcium chelator targeting intracellular and extracellular calcium ion concentrations. This reagent is instrumental in the investigation of calcium signaling and physiological processes, providing researchers with the ability to manipulate calcium levels within various experimental settings. Its buffering capabilities make it suitable for a wide range of biological studies focused on calcium dynamics.

Cat. No.

A43841

CAS No.

172646-43-4

5-Nitro BAPTA tetramethyl ester

5-Nitro BAPTA tetramethyl ester is a potent calcium chelator that effectively modulates intracellular calcium levels. It is utilized in the synthesis of two-photon probes, enabling real-time imaging and monitoring of calcium ion fluctuations and calcium waves in liver tissues at depths of 100-300 μm over extended durations of 1100-4000 seconds. Additionally, when combined with the fluorescent compound 2-Me-substituted TM, it can be employed to create a red fluorescent probe known as CaTM-2 AM, enhancing its utility in calcium-related biological research.

Cat. No.

A46590

CAS No.

134-31-6

8-Hydroxyquinoline hemisulfate

Synonyms: 8-Quinolinol hemisulfate

8-Hydroxyquinoline hemisulfate is a monoprotic bidentate chelating agent that exhibits notable antiseptic, disinfectant, and pesticidal properties. It functions as a transcription inhibitor, making it useful in studies involving gene expression regulation and molecular biology applications. This compound is commonly employed in research focused on metal ion chelation and various biochemical assays.

Cat. No.

A47901

CAS No.

6381-92-6

Ethylenediaminetetraacetic acid disodium dihydrate

Synonyms: EDTA disodium dihydrate

Ethylenediaminetetraacetic acid disodium dihydrate is a metal chelator that effectively binds bivalent and trivalent metal cations, such as calcium. With notable antibacterial, anti-inflammatory, antioxidant, and anticoagulant properties, this compound mitigates metal ion-catalyzed oxidative damage to proteins and helps maintain a reducing environment during protein purification. Additionally, it demonstrates potential therapeutic effects in liver fibrosis and is applicable in research related to coronary artery disease and neurological disorders.

Cat. No.

A48091

CAS No.

64-02-8

Ethylenediaminetetraacetic acid tetrasodium

Synonyms: EDTA tetrasodium

Ethylenediaminetetraacetic acid tetrasodium (EDTA tetrasodium) is a potent metal chelator that binds to bivalent and trivalent metal cations, including calcium. This compound exhibits various biological activities, including antibacterial, anti-inflammatory, antioxidant, and anticoagulant effects. EDTA tetrasodium mitigates metal ion-catalyzed oxidative damage to proteins and supports a reducing environment during protein purification processes. Its application extends to research in liver fibrosis, coronary artery disease, and neurological disorders, making it a valuable tool in biochemical studies.

Cat. No.

A48098

CAS No.

6766-87-6

Ca(II)-EDTA disodium dihydrate

Synonyms: Calcium disodium EDTA dihydrate

Ca(II)-EDTA disodium dihydrate is a metal chelating agent that effectively binds divalent metal ions. This compound exhibits bactericidal activity against periodontal pathogens, including Aggregatibacter actinomycetemcomitans, Prevotella intermedia, and Porphyromonas gingivalis. Additionally, it serves as an effective chelating antidote in cases of lead and cadmium poisoning, making it a valuable reagent in toxicology and microbiological research.

Cat. No.

A48601

CAS No.

10378-23-1

Ethylenediaminetetraacetic acid sodium hydrate

Synonyms: EDTA sodium hydrate

Ethylenediaminetetraacetic acid sodium hydrate is a metal chelator that effectively binds to bivalent and trivalent metal cations, including calcium. It exhibits significant biological activities such as antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemic, and anticoagulant properties. This compound is particularly useful in mitigating metal ion-catalyzed oxidative damage to proteins, thus facilitating the maintenance of a reducing environment during protein purification. Ethylenediaminetetraacetic acid sodium hydrate is also investigated for its potential therapeutic effects in studies related to liver fibrosis, coronary artery disease, and neurological disorders.

Cat. No.

A53061

CAS No.

76045-30-2

Desferriferrithiocin

Synonyms: CGP 23841A

Desferriferrithiocin is an iron chelator that effectively inhibits the growth of Plasmodium falciparum in a dose-dependent manner. This compound's primary mechanism involves sequestering iron, thereby disrupting the pathogen's growth and survival. Desferriferrithiocin is valuable for research applications focused on malaria biology and the development of antimalarial therapeutics.

Cat. No.

A53715

CAS No.

4961-41-5

Tetraethylenepentamine pentahydrochloride

Tetraethylenepentamine pentahydrochloride is a potent copper chelator, primarily targeting metal ions to facilitate their removal from biological systems. This compound enhances urinary excretion of copper, making it valuable in research focused on copper metabolism disorders and related toxicological studies. Its ability to bind copper ions is critical for investigations into therapies for conditions associated with copper overload.

Cat. No.

A70054

CAS No.

370-81-0

Cuprizone

Cuprizone is a copper chelator that forms a distinct blue complex with copper (II), making it useful for colorimetric detection of trace copper levels. It is employed in animal models to induce schizophrenia-like behaviors, enabling the study of psychiatric conditions. Cuprizone primarily affects copper-dependent enzymes, such as superoxide dismutase 1 (SOD1) and cytochrome oxidase, leading to oxidative stress and increased dopamine levels in brain regions like the medial prefrontal cortex (PFC). This reagent is valuable for research involving neurobiology and oxidative stress mechanisms.

Cat. No.

A71823

CAS No.

51981-21-6

Tetrasodium glutamate diacetate (46% in water)

Tetrasodium glutamate diacetate (46% in water) is a biodegradable chelating agent that interacts with metal ions, enhancing antibacterial efficacy in various applications. Its primary function is to improve the effectiveness of multifunctional additives in cosmetic formulations. This chelating agent provides significant advantages in maintaining product stability and efficacy by minimizing the adverse effects of metal ions. It is commonly utilized in cosmetic and personal care products to ensure optimal performance.

Cat. No.

A74413

CAS No.

34367-89-0

Phytic acid hexasodium

Synonyms: Inositol hexaphosphate hexasodium; SNF472

Phytic acid hexasodium, an effective chelating agent, functions primarily by binding multivalent metal ions, notably zinc, calcium, and iron. This compound exhibits significant antioxidative, neuroprotective, and anti-inflammatory properties, and also inhibits the enzyme xanthine oxidase (XO), a major source of superoxide. Its versatile biological activity makes phytic acid hexasodium valuable in various research applications, particularly in studies focused on oxidative stress and inflammation.