Chelators & Bifunctional Chelators

Cat. No.

A91293

CAS No.

1613382-10-7

Maleimido-mono-amide-DOTA-tris(t-Bu ester)

Maleimido-mono-amide-DOTA-tris(t-Bu ester) is a bifunctional chelator (BFC) and a macrocyclic DOTA derivative designed for tumor pre-targeting applications. This compound facilitates the conjugation of peptides and radionuclides, enabling enhanced targeting and imaging of tumor cells in research settings. Its unique structure allows for efficient radiolabeling, making it a valuable reagent for studies in nuclear medicine and molecular imaging.

Cat. No.

A91342

CAS No.

2719737-44-5

Salpyran

Salpyran is a selective chelator for copper ions (Cu(II)), effectively binding and sequestering this metal ion. Its primary mechanism involves high-affinity interaction with Cu(II), which can modulate copper's biological availability. Salpyran demonstrates potential therapeutic applications in conditions characterized by copper dysregulation, making it a valuable tool for research in metal ion homeostasis and related diseases.

Cat. No.

A91489

CAS No.

446061-19-4

p-NH2-Bn-DOTA-tetra(t-Bu ester)

p-NH2-Bn-DOTA-tetra(t-Bu ester) is a bifunctional chelator (BFC) and a macrocyclic DOTA derivative designed for tumor pre-targeting. This compound enables efficient conjugation of peptides and radionuclides, facilitating targeted drug delivery and imaging applications in cancer research. Its structure enhances stability and functionality, making it a valuable tool in the development of radiopharmaceuticals.

Cat. No.

A91523

CAS No.

99478-30-5

Phytochelatin 6

Synonyms: PC 6

Phytochelatin 6 is a metal-binding compound that plays a crucial role in phytoremediation by sequestering heavy metals such as cadmium. It is primarily synthesized by plants in response to heavy metal exposure, thus reducing the bioavailability of these toxic metals in the environment. This compound is valuable for research applications in environmental science, toxicology, and plant physiology, facilitating the study of metal detoxification processes in plants.

Cat. No.

A91767

CAS No.

1822331-55-4

p-SCN-Bn-HOPO

p-SCN-Bn-HOPO is a bifunctional chelating agent that selectively binds to the radioactive isotope zirconium-89 (^89Zr). This compound is utilized in ImmunoPET applications, enhancing imaging techniques in preclinical and clinical research. Its ability to form stable complexes with ^89Zr makes it a valuable tool for tracking biological processes and evaluating therapeutic responses in vivo.

Cat. No.

A91981

CAS No.

2649490-34-4

p-SCN-Bn-PCTA hydrochloride

p-SCN-Bn-PCTA hydrochloride is a bifunctional chelator that serves as a macrocyclic DTPA derivative, primarily targeting tumor pre-targeting applications. This compound facilitates the conjugation of peptides and radionuclides, making it a valuable tool in radioimmunotherapy and imaging studies. Its ability to form stable complexes with metal ions enhances its utility in bioconjugation processes within cancer research.

Cat. No.

A92017

CAS No.

1823122-52-6

DOTA-NHS-ester hexafluorophosphate TFA

DOTA-NHS-ester hexafluorophosphate TFA is a bifunctional chelator (BFC) that serves as a macrocyclic DOTA derivative designed for tumor pre-targeting applications. This reagent facilitates the efficient conjugation of peptides and radionuclides, making it valuable in cancer research and therapeutic studies. Its unique structure allows for optimized binding and functionalization, enhancing the efficacy of targeted treatments.

Cat. No.

A92018

CAS No.

2614335-77-0

Bz-DTPA hydrochloride

Bz-DTPA hydrochloride is a bifunctional chelator that serves as a macrocyclic DTPA derivative, primarily targeting tumor pre-targeting applications. Its ability to facilitate the conjugation of peptides and radionuclides makes it valuable for research in targeted therapy and radiopharmaceutical development. This reagent is utilized in studies focusing on enhancing the specificity and efficacy of therapeutic and diagnostic agents in oncology.

Cat. No.

A92139

CAS No.

139265-92-2

Diamsar hydrochloride

Diamsar hydrochloride is a bifunctional chelator that demonstrates a strong capacity for metal ion coordination. It serves as a useful tool in biochemical research for metal ion detection and purification processes. Its ability to bind various metal ions enables applications in cellular imaging and therapeutic development, particularly in studies involving metal-dependent enzymes and pathways.

Cat. No.

A92180

CAS No.

14402-88-1

EDTA magnesium disodium,99%

EDTA magnesium disodium, 99% is a potent chelating agent that effectively binds metal ions such as calcium, magnesium, and iron. Its primary mechanism involves forming stable complexes with these ions, facilitating their removal from solution. This reagent is widely utilized in biochemical and molecular biology research to control metal ion concentrations and study their effects on biological systems.

Cat. No.

A92460

CAS No.

1260798-95-5

CB-TE2A tetrahydrochloride

CB-TE2A tetrahydrochloride is a bifunctional chelator (BFC) characterized by its TETA derivative structure and macrocyclic tetradecane backbone. This reagent effectively facilitates the conjugation of peptides and radionuclides, making it a valuable tool in radiolabeling and molecular imaging studies. Its unique properties enable diverse applications in biochemistry and biophysics, particularly in the development of targeted therapeutics and diagnostic agents.

Cat. No.

A92840

CAS No.

1370442-99-1

p-SCN-Bn-oxo-DO3A

p-SCN-Bn-oxo-DO3A is a bifunctional chelator (BFC) and a macrocyclic DOTA derivative, primarily targeting tumor pre-targeting applications. This reagent facilitates the conjugation of peptides and radionuclides, enabling effective labeling and delivery systems in molecular imaging and targeted radiotherapy. Its versatile chemistry makes it an essential tool for researchers investigating novel diagnostic and therapeutic strategies in oncology.

Cat. No.

A93342

CAS No.

34369-82-9

Ferric glycinate

Ferric glycinate is an iron amino acid chelate that serves as a key agent in the prevention and treatment of iron deficiency anemia. By enhancing iron bioavailability, it supports effective iron supplementation in various therapeutic applications. Additionally, it is utilized as a food fortifier, improving the nutritional profile of dietary products. Ferric glycinate is valuable in both clinical and nutritional research settings focused on addressing iron-related deficiencies.

Cat. No.

A93392

CAS No.

13007-85-7

Sodiumα-glucoheptonate，97%

Sodium α-glucoheptonate serves as a multifunctional chelating agent, effectively forming stable complexes with a variety of metal ions. Its ability to chelate metal ions makes it valuable in applications such as environmental analysis, biochemical assays, and metal ion detoxification. This reagent is particularly useful in studies involving metal ion interactions and can facilitate the investigation of metal ion-dependent biological processes.

Cat. No.

A93703

CAS No.

13978-85-3

Zinc oxinate

Synonyms: Bis(8-quinolinolato)zinc(II) hydrate; Zinc 8-hydroxyquinolinate

Zinc oxinate, also known as Zinc 8-hydroxyquinolinate, functions as a metal chelator by forming stable pentacoordinate or hexacoordinate complexes with zinc ions. Its ability to effectively stabilize zinc complexes makes it a valuable tool for research involving zinc quantification and analysis. This compound is particularly useful in biochemical studies examining the role of zinc in various biological processes.

Cat. No.

A93883

CAS No.

39208-15-6

EDTA copper(II) disodium salt, 97%

EDTA copper(II) disodium salt is a chelating agent that effectively binds copper ions through ethylenediaminetetraacetic acid (EDTA) interactions. This compound demonstrates significant biological activity by forming stable complexes with chitosan in weakly acidic environments and producing the CuEDTA(OH)3− hydroxyl complex under strongly alkaline conditions (pH > 12). Its ability to adsorb onto granular activated carbon via electrostatic interactions facilitates its use in various research applications, including the removal of trace heavy metal inhibition in enzyme-catalyzed reactions. This makes EDTA copper(II) disodium salt a valuable tool in biochemical and environmental studies.

Cat. No.

A93980

CAS No.

12111-24-9

Pentetate calcium trisodium

Synonyms: Ca-DTPA trisodium

Pentetate calcium trisodium (Ca-DTPA) acts as a potent chelating agent, effectively forming stable complexes with heavy metal ions by replacing calcium with ions exhibiting greater binding affinity. This property makes it useful in research applications aimed at detoxifying metal contaminants and studying metal ion interactions in biological systems. Ca-DTPA is utilized in various fields, including environmental research and biomedical studies, where metal ion concentration control is critical.

Cat. No.

A94334

CAS No.

11082-38-5

Pentetate zinc trisodium

Synonyms: Zn-DTPA trisodium

Pentetate zinc trisodium, a chelating agent, effectively forms stable complexes with various metal ions by exchanging zinc for metals with higher affinity. This property enables its application in studies related to metal ion detoxification, radiopharmaceuticals, and metal ion transport mechanisms. Its ability to sequester metal ions makes it valuable in toxicology, pharmacology, and molecular biology research.

Cat. No.

A94455

CAS No.

110874-36-7

3,4,3-LI(1,2-HOPO)

Synonyms: HOPO 14-1

3,4,3-LI(1,2-HOPO) is a highly effective metal chelating agent with a strong affinity for lanthanide metal ions. This compound is utilized extensively in research applications involving metal ion coordination, separation, and detection. Its exceptional chelating properties make it valuable for studies in biochemistry, environmental monitoring, and material science, where precise metal ion management is essential.

Cat. No.

A94543

CAS No.

115900-75-9

CGP 46700

CGP 46700 is an orally active iron chelator that exhibits a high affinity for iron, effectively removing iron from ferritin and human serum transferrin. This compound demonstrates the ability to promote iron excretion in models of iron overload, making it valuable for research in iron metabolism and potential therapeutic applications in iron-related disorders.

Cat. No.

A94760

CAS No.

191486-46-1

(E,E)-ATSM

(E,E)-ATSM is a chelating agent that exhibits a strong affinity for various transition metals, particularly copper. It can form complexes with metallized ligands such as copper gluconate, thereby aiding in the elucidation of metal ion interactions in biological systems. This compound is particularly relevant for research into central nervous system diseases, providing insights into neurodegeneration and metal homeostasis.

Cat. No.

A94802

CAS No.

142-73-4

Iminodiacetic acid

Iminodiacetic acid is a metal chelating agent that targets Cr6+, Cd2+, Ni2+, and Pb2+. This compound effectively binds metal ions through the coordination of its carboxyl and imino groups, reducing their toxicity and facilitating their adsorption and separation. Iminodiacetic acid is widely utilized in environmental pollution control, particularly in heavy metal removal from water, as well as in coordination chemistry for metal ion detection and separation applications.

Cat. No.

A98806

CAS No.

1206475-68-4

(S)-P-SCN-BN-NOTA

(S)-P-SCN-BN-NOTA is a bifunctional chelating agent that facilitates the covalent attachment of the radioactive nuclide ⁶⁴Cu to ZPDGFRβ affibody, forming the molecular probe [⁶⁴Cu]Cu-NOTA-ZPDGFRβ. This compound is crucial for applications in positron emission tomography (PET), enabling precise imaging of tumors expressing the ZPDGFRβ receptor. Its ability to effectively conjugate with radionuclides makes it valuable in the development of targeted radiotherapy and diagnostic imaging agents.

Cat. No.

A99976

CAS No.

3078821-76-5

DOTA-tris(t-Bu)ester-PEG3-C2-amine

DOTA-tris(t-Bu)ester-PEG3-C2-amine is a conjugate functioning as a chelating agent and linker. It features a DOTA-based chelator combined with tris(t-Bu) ester and PEG3-C2-amine groups, facilitating versatile conjugation. This compound enables targeted delivery of various payloads through bioorthogonal click chemistry, making it suitable for applications in drug delivery and targeted therapies within chemical biology and nanomedicine.

Cat. No.

B18456

CAS No.

27501-91-3

Aeruginoic acid

Aeruginoic acid is a potent iron chelator that acts by binding free iron ions, thereby reducing oxidative stress and modulating iron homeostasis. This compound has been shown to exhibit hypotensive activity, making it relevant for investigations into cardiovascular health. Its applications in research include studying the effects of iron depletion on cellular metabolism and exploring therapeutic strategies for iron-related disorders.