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E3 Ligase Ligands

E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.

Cat. No.

A80897

CAS No.

3031608-33-7

CRBN ligand-230

CRBN ligand-230 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN in targeted protein degradation applications. This compound can be conjugated to target protein ligands via a linker, thereby enabling the formation of PROTACs (Proteolysis Targeting Chimeras). CRBN ligand-230 is instrumental in research focused on ubiquitination processes and therapeutic strategies for targeted protein modulation.

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Cat. No.

A80898

CAS No.

2925096-31-5

CRBN ligand-559

CRBN ligand-559 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). It is valuable for research applications focused on targeted protein degradation pathways and the exploration of E3 ligase-mediated ubiquitination processes.

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Cat. No.

A80899

CAS No.

3023408-98-9

CRBN ligand-203

CRBN ligand-203 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). It serves a critical role in targeted protein degradation studies and is useful for research into therapeutic applications involving the modulation of protein levels within cells.

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Cat. No.

A80900

CAS No.

2925091-17-2

CRBN ligand-355

CRBN ligand-355 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to specific target protein ligands through a linker to create PROTACs (Proteolysis Targeting Chimeras), enabling targeted protein degradation. It serves as a valuable tool for researchers investigating protein dynamics, ubiquitination pathways, and therapeutic strategies in cancer and other diseases.

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Cat. No.

A80901

CAS No.

2925102-38-9

CRBN ligand-335

CRBN ligand-335 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the construction of PROTACs by linking it to other target protein ligands via a suitable linker. Its application supports the study of targeted protein degradation and the modulation of protein levels in various biological contexts.

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Cat. No.

A80902

CAS No.

2925095-98-1

CRBN ligand-561

CRBN ligand-561 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to assemble a PROTAC (Proteolysis Targeting Chimera) by linking it to a target protein ligand through a suitable linker. Research applications include targeted protein degradation and investigations into proteostasis mechanisms, offering insights into therapeutic strategies for various diseases.

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Cat. No.

A80903

CAS No.

2789679-89-4

CRBN ligand-411

CRBN ligand-411 is a small molecule ligand that targets the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment to specific protein substrates. This compound can be utilized in the development of proteolysis targeting chimeras (PROTACs) by linking to a target protein ligand through a suitable linker. CRBN ligand-411 supports research in targeted protein degradation, enabling the investigation of cellular processes and therapeutic applications in various diseases.

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Cat. No.

A80904

CAS No.

2925074-73-1

CRBN ligand-699

CRBN ligand-699 is a small molecule ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein, enabling targeted degradation of specific proteins when linked to a target protein ligand through a suitable linker. This compound is instrumental in the development of PROTACs (proteolysis-targeting chimeras) for research applications focused on ubiquitin-mediated protein turnover and targeted therapy strategies.

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Cat. No.

A80905

CAS No.

2925100-60-1

CRBN ligand-755

CRBN ligand-755 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), functioning to selectively recruit the CRBN protein. This compound is designed for use in PROTAC (protasome-targeting chimeras) development, allowing for targeted protein degradation in cellular studies. Its ability to link to a target protein ligand via a linker opens avenues for manipulating protein levels in various biological research applications.

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Cat. No.

A80906

CAS No.

3036607-75-4

CRBN ligand-162

CRBN ligand-162 is a ligand for the CRBN-type E3 ubiquitin ligase, facilitating the targeted degradation of proteins through the ubiquitin-proteasome system. This compound is utilized in the design and synthesis of PROTACs (Proteolysis Targeting Chimeras), which are powerful tools for selective protein degradation in various biological research applications. Its utilization promotes advancements in understanding protein function and therapeutic interventions in diseases linked to protein dysregulation.

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Cat. No.

A80907

CAS No.

2925082-29-5

CRBN ligand-636

CRBN ligand-636 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be utilized in the design of PROTACs (Proteolysis Targeting Chimeras) by linking it to a target protein ligand through a linker, enabling targeted ubiquitination and degradation of the desired protein. CRBN ligand-636 is valuable in research applications aimed at exploring protein function, degradation pathways, and therapeutic interventions in various diseases.

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Cat. No.

A80908

CAS No.

2925090-15-7

CRBN ligand-571

CRBN ligand-571 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be utilized to synthesize PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. Its distinctive mechanism of action makes it a valuable tool for probing protein degradation pathways and studying the dynamics of protein homeostasis in cellular systems.

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Cat. No.

A80909

CAS No.

2858741-81-6

CRBN ligand-616

CRBN ligand-616 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This reagent can be conjugated with a target protein ligand through a linker to generate a proteolysis-targeting chimeric molecule (PROTAC). It supports research in targeted protein degradation, offering potential applications in therapeutic development and cellular signaling studies.

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Cat. No.

A80910

CAS No.

2925095-36-7

CRBN ligand-631

CRBN ligand-631 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is instrumental in the design of PROTACs (Proteolysis Targeting Chimeras) by allowing the conjugation of a target protein ligand through a suitable linker. Its ability to modulate protein degradation pathways makes it valuable for research into targeted protein degradation and therapeutic applications.

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Cat. No.

A80911

CAS No.

2641512-73-2

CRBN ligand-209

CRBN ligand-209 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted recruitment of the CRBN protein. This compound can be conjugated to a specific target protein ligand through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). It is valuable for research applications focused on targeted protein degradation and exploring protein turnover mechanisms within cellular systems.

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Cat. No.

A80912

CAS No.

2925095-65-2

CRBN ligand-418

CRBN ligand-418 is a novel ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound is designed to facilitate the recruitment of CRBN to target proteins when conjugated via a linker, thereby enabling the formation of Proteolysis Targeting Chimeras (PROTACs). Its application in targeted protein degradation offers significant potential in therapeutic research and development.

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Cat. No.

A80913

CAS No.

2925082-19-3

CRBN ligand-695

CRBN ligand-695 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein in targeted protein degradation applications. It can be conjugated with a target protein ligand through a linker to create a PROTAC, enabling the selective degradation of specific proteins. This compound is valuable for research focused on targeted therapeutics and the manipulation of cellular protein levels.

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Cat. No.

A80914

CAS No.

2925097-91-0

CRBN ligand-687

CRBN ligand-687 is a small molecule ligand that targets the E3 ubiquitin ligase cereblon (CRBN). It is designed to facilitate the recruitment of cereblon to specific target proteins, enabling the formation of PROTACs (Proteolysis Targeting Chimeras). This compound is valuable for studies related to targeted protein degradation and offers potential applications in therapeutic development.

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Cat. No.

A80915

CAS No.

2858743-52-7

CRBN ligand-614

CRBN ligand-614 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand via a linker, enabling the formation of a proteolysis-targeting chimeric molecule (PROTAC). CRBN ligand-614 is valuable for research applications in targeted protein degradation and the study of ubiquitin-proteasome pathway mechanisms.

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Cat. No.

A80916

CAS No.

2925092-10-8

CRBN ligand-354

CRBN ligand-354 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in targeted protein degradation approaches, such as the development of PROTACs, by linking it to a target protein ligand through a suitable linker. Its role in protein homeostasis and degradation pathways makes it valuable for studying therapeutic mechanisms in various biological contexts.

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Cat. No.

A80917

CAS No.

2925081-13-4

CRBN ligand-437

CRBN ligand-437 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the assembly of CRBN with target proteins. This compound can be utilized in the design of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. Research applications include studies on protein degradation pathways and the development of targeted protein degradation strategies for therapeutic purposes.

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Cat. No.

A80918

CAS No.

1049801-63-9

CRBN ligand-889

CRBN ligand-889 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of CRBN to target proteins. This compound can be conjugated with a target protein ligand through a linker, allowing the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-889 is instrumental in studying protein degradation pathways and the development of targeted therapies leveraging the ubiquitin-proteasome system.

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Cat. No.

A80919

CAS No.

2925101-82-0

CRBN ligand-250

CRBN ligand-250 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation applications. This compound can be conjugated to target protein ligands through a linker to create a PROTAC (proteolysis-targeting chimera), allowing for the selective degradation of substrate proteins. Its utility in research encompasses the study of protein homeostasis and therapeutic interventions in various diseases.

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Cat. No.

A80920

CAS No.

2925075-98-3

CRBN ligand-380

CRBN ligand-380 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of cereblon, enabling the targeted degradation of specific proteins through the formation of PROTACs (Proteolysis Targeting Chimeras). CRBN ligand-380 is instrumental in research applications aimed at exploring targeted protein degradation and ubiquitin-mediated proteolysis.

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Cat. No.

A80921

CAS No.

2152673-38-4

CRBN ligand-408

CRBN ligand-408 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is pivotal for the development of proteolysis-targeting chimeras (PROTACs) by linking target protein ligands through a suitable linker. It is useful in studying the modulation of protein degradation pathways and exploring the therapeutic potential of targeted protein degradation.

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