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E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.
CRBN ligand-334 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be effectively conjugated to a target protein ligand through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). Researchers can utilize CRBN ligand-334 in studies aimed at targeted protein degradation and the modulation of cellular pathways.
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CRBN ligand-183 is a ligand for the CRBN-type E3 ubiquitin ligase, facilitating the development of PROTACs (proteolysis-targeting chimeras). This compound enables targeted protein degradation by harnessing the cellular ubiquitin-proteasome system. It is a valuable tool for research applications in drug discovery and development, particularly in understanding protein function and regulation.
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CRBN ligand-313 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed to be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-313 serves as a valuable tool for studying targeted protein degradation and its applications in drug discovery and therapeutic development.
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CRBN ligand-301 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized to conjugate with target protein ligands through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). Its application in research enables the study of targeted protein degradation pathways, expanding the potential for therapeutic development in various biological contexts.
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CRBN ligand-708 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of CRBN to specific target proteins. This compound can be utilized to construct proteolysis-targeting chimeras (PROTACs) by linking it with a target protein ligand through a suitable linker. CRBN ligand-708 is valuable for studying targeted protein degradation and exploring potential therapeutic applications in various diseases.
CRBN ligand-233 acts as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis-targeting chimera). It is utilized in research to explore targeted protein degradation pathways and develop novel therapeutic strategies in various disease models.
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CRBN ligand-709 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the targeted recruitment of this protein. It serves as a valuable tool for the development of proteolysis-targeting chimeras (PROTACs) by facilitating the linkage of a target protein ligand through a suitable linker. This compound is instrumental in studying protein degradation pathways and advancing targeted protein degradation research.
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CRBN ligand-441 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for targeted protein degradation applications. By connecting CRBN ligand-441 to a target protein ligand through a linker, it can be utilized to create a PROTAC (proteolysis-targeting chimera), thereby enabling selective modulation of protein levels in cellular processes. This compound is valuable in the study of protein dynamics and therapeutic development in various diseases.
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CRBN ligand-483 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a specific target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis targeting chimera) for targeted protein degradation studies. It serves as a valuable tool in the exploration of protein turnover and disease mechanisms related to ubiquitination pathways.
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CRBN ligand-420 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. This compound is designed for use in the development of proteolysis-targeting chimeras (PROTACs), enabling targeted degradation of specific proteins through the ubiquitin-proteasome system. CRBN ligand-420 is valuable for applications in drug discovery and protein regulation studies.
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CRBN ligand-110 serves as a selective ligand for the CRBN E3 ubiquitin ligase, facilitating the development of PROTAC (Proteolysis Targeting Chimeras). Its integration into PROTAC designs allows for targeted degradation of specific proteins, making it a valuable tool in drug discovery and therapeutic research. This compound is instrumental in exploring novel approaches to modulate protein levels and activity in cellular systems.
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CRBN ligand-514 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, allowing the formation of a PROTAC (proteolysis-targeting chimeras). CRBN ligand-514 is instrumental in the study of targeted protein degradation and therapeutic applications in cancer and other diseases.
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CRBN ligand-573 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein to target proteins. This compound can be conjugated with a target protein ligand using a linker to create a PROTAC (proteolysis-targeting chimera), enabling selective degradation of specific proteins. CRBN ligand-573 is valuable for research in targeted protein degradation and cellular regulation studies.
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CRBN ligand-63 is a ligand for the CRBN-type E3 ubiquitin ligase, functioning as a key component in the development of PROTAC (proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by harnessing the cellular ubiquitin-proteasome system, offering valuable utility in research focused on protein regulation and therapeutic interventions. Its application extends to the study of cellular pathways and the modulation of protein levels in various biological contexts.
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CRBN ligand-300 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be effectively conjugated to a target protein ligand using a linker to generate a Proteolysis Targeting Chimera (PROTAC). Its application is significant in studies focused on targeted protein degradation and pharmacological interventions in various biological systems.
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CRBN ligand-276 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound serves as a critical component for the development of PROTACs (Proteolysis Targeting Chimeras), which are utilized to promote targeted protein degradation. Its applications are particularly relevant in studies focusing on protein regulation and cellular signaling pathways in various diseases.
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CRBN ligand-707 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be effectively utilized to create proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its applications are vital in research related to targeted protein degradation and the modulation of cellular pathways governed by ubiquitin-proteasome system.
CRBN ligand-396 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in cellular systems. This compound can be coupled with a ligand targeting a specific protein through a suitable linker to create a proteolysis-targeting chimera (PROTAC). It allows for targeted degradation of proteins, enabling nuanced investigations into protein function and regulation. Key applications include the study of ubiquitin-proteasome pathway mechanisms and protein homeostasis.
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CRBN ligand-451 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for targeted protein degradation. It can be conjugated to a target protein ligand through a linker, enabling the construction of PROTACs (proteolysis-targeting chimeras). This compound is instrumental in research applications aimed at elucidating protein regulation and degradation mechanisms within cellular contexts.
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CRBN ligand-518 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It functions by recruiting cereblon to target proteins, facilitating their ubiquitination and subsequent degradation. This compound is utilized in research applications involving proteolysis-targeting chimeras (PROTACs), enabling the targeted degradation of specific proteins within cellular systems.
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CRBN ligand-339 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. It can be utilized to construct PROTACs (Proteolysis Targeting Chimeras) when linked to a specific target protein ligand via a suitable linker. This compound plays a critical role in targeted protein degradation research, enabling studies on ubiquitination and protein turnover.
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CRBN ligand-184 is a selective ligand for CRBN-type E3 ubiquitin ligases. This compound plays a crucial role in the development of proteolysis-targeting chimeras (PROTACs), including the synthesis of PROTAC AU-24118. Its ability to engage E3 ligases provides valuable tools for targeted protein degradation research and the investigation of cellular protein dynamics.
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(S,R,S)-AHPC 2-OH hydrochloride is a ligand for the E3 ubiquitin ligase VHL, facilitating the recruitment of the VHL protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of PROTACs for targeted protein degradation applications in chemical biology research. Its utility in studying ubiquitin-proteasome system pathways makes it a valuable tool for investigating protein regulation and degradation mechanisms.
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CRBN ligand-259 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the targeted recruitment of the CRBN protein. This compound can be utilized to construct Proteolysis Targeting Chimeras (PROTACs) by linking it to a target protein ligand via a suitable linker. CRBN ligand-259 is instrumental in studies aimed at modulating protein degradation pathways, providing insights into protein homeostasis and potential therapeutic interventions.
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CRBN ligand-639 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand using a linker to create a proteolysis-targeting chimera (PROTAC). CRBN ligand-639 is instrumental in elucidating ubiquitin-mediated protein degradation pathways and has applications in targeted protein degradation research.
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