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E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.
CRBN ligand-509 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be effectively combined with target protein ligands through a linker to create a PROTAC, enabling targeted protein degradation. Its applications include studying the mechanisms of targeted protein degradation and exploring therapeutic strategies in cancer and other diseases.
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CRBN ligand-416 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to create a PROTAC (proteolysis-targeting chimeric molecule) by linking it to a target protein ligand through a suitable linker. CRBN ligand-416 is instrumental in research applications involving targeted protein degradation and the study of ubiquitin-mediated proteolysis.
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CRBN ligand-266 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound is designed for use in the development of proteolysis-targeting chimeras (PROTACs) by enabling covalent linkage to a target protein ligand through a suitable linker. Its application in research can enhance understanding of specific protein degradation pathways and promote the study of therapeutic targets in various diseases.
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CRBN ligand-305 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. By linking CRBN ligand-305 to a target protein ligand through a suitable linker, researchers can construct proteolysis targeting chimeras (PROTACs) that promote targeted protein degradation. This compound is instrumental in studying the role of protein ubiquitylation and has potential applications in drug discovery and therapeutic development.
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CRBN ligand-597 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound provides a strategic tool for the development of PROTACs (proteolysis-targeting chimeras) by enabling the linkage of a target protein ligand via a suitable linker. Its application is significant in studies focused on targeted protein degradation and the modulation of cellular pathways.
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CRBN ligand-361 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to form a PROTAC, thereby promoting targeted protein degradation. CRBN ligand-361 is valuable in research applications focused on ubiquitin-proteasome system modulation and protein homeostasis.
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CRBN ligand-278 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. It can be utilized in the design of PROTACs (Proteolysis Targeting Chimeras) by linking to a target protein ligand through an appropriate linker. This compound is instrumental in studying protein degradation pathways and offers potential applications in targeted protein modulation for therapeutic purposes.
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CRBN ligand-564 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of small-molecule PROTACs for targeted protein degradation studies. Its applications extend to drug discovery and the exploration of ubiquitin-proteasome pathway mechanisms.
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Hydrouracil-4-Iodophenyl is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this essential protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC), enabling selective degradation of specific proteins. It is a valuable tool for studies investigating protein turnover and therapeutic applications in various diseases.
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CRBN ligand-446 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound is designed to be coupled with a target protein ligand through a linker to generate a proteolysis-targeting chimera (PROTAC). It plays a crucial role in targeted protein degradation research, offering applications in drug discovery and the study of cellular signaling pathways.
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4-Me-Thalidomide is an E3 ligase activator characterized by the presence of a methyl group. This compound enhances the activity of E3 ligases, which are crucial for tagging proteins with ubiquitin for targeted proteolytic degradation. 4-Me-Thalidomide can be utilized in research applications investigating protein turnover and the ubiquitin-proteasome system, offering insights into cellular processes and disease mechanisms.
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CRBN ligand-226 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to create a proteolysis-targeting chimera (PROTAC). Its application in targeted protein degradation allows for the selective modulation of protein levels in various biological systems, making it a valuable tool in chemical biology and therapeutic research.
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CRBN ligand-533 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It can be conjugated to target protein ligands using a linker to generate proteolysis targeting chimeras (PROTACs). This reagent is instrumental in advancing research on targeted protein degradation and cellular signaling pathways.
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CRBN ligand-83 is a ligand for the CRBN E3 ubiquitin ligase, facilitating targeted protein degradation via the PROTAC (proteolysis-targeting chimera) technology. This compound enhances the recruitment of E3 ligases to specific substrates, enabling efficient ubiquitination and subsequent proteasomal degradation of target proteins. CRBN ligand-83 is a valuable tool in chemical biology research for studying protein function and the development of therapeutics that harness the ubiquitin-proteasome system.
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CRBN ligand-591 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). It is utilized in research applications focused on targeted protein degradation and the modulation of cellular protein levels.
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CRBN ligand-340 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein, allowing for the targeted degradation of specific proteins through the formation of PROTAC molecules when conjugated to a target protein ligand via a linker. This compound is useful in research applications exploring protein degradation pathways and therapeutic strategies that harness the ubiquitin-proteasome system.
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CRBN ligand-279 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), utilized to recruit the CRBN protein. This compound can be conjugated to a target protein ligand via a linker, facilitating the formation of PROTACs. Its applications include research in targeted protein degradation and the study of cellular protein regulation mechanisms.
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CRBN ligand-534 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. Its applications include advancing research in targeted therapies and elucidating protein turnover mechanisms in various biological contexts.
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CRBN ligand-372 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It can be utilized to synthesize proteolysis-targeting chimeras (PROTACs) by linking it to a ligand of a target protein through a suitable linker. This compound supports research into targeted protein degradation, offering potential applications in cancer therapy and other therapeutic areas involving ubiquitin-proteasome system modulation.
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CRBN ligand-317 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound is integral in the recruitment of CRBN for the targeted degradation of specific proteins when linked to target protein ligands via a suitable linker, facilitating the development of PROTACs. It serves as a valuable tool in chemical biology and therapeutic research, particularly in studies involving targeted protein degradation strategies.
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CRBN ligand-603 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). Its innovative design enables targeted protein degradation, making it a valuable tool for biological research and therapeutic potential in drug development.
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CRBN ligand-739 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate protein recruitment to intracellular ubiquitination pathways. By linking CRBN ligand-739 to a specific target protein ligand through a suitable linker, researchers can develop proteolysis-targeting chimeras (PROTACs). This compound is valuable for studying targeted protein degradation and its implications in various therapeutic contexts, particularly in cancer research.
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CRBN ligand-222 is a small molecule ligand that selectively targets the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling the formation of Proteolysis Targeting Chimeras (PROTACs). This compound is valuable for research applications in targeted protein degradation and the investigation of ubiquitin-mediated pathways.
CRBN ligand-309 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted recruitment of CRBN to specific proteins. This compound can be employed in the synthesis of PROTACs (Proteolysis Targeting Chimeras) by linking it to a ligand specific for a target protein. CRBN ligand-309 is valuable for studying protein degradation pathways and developing targeted therapeutic strategies in cancer research and other diseases.
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NH2-MeO-Ph-amide-(2,6-Dioxo-3-Pip) is a ligand that targets Cereblon (CRBN), a key component of the E3 ubiquitin ligase complex. This compound facilitates the synthesis of PROTAC BRD4 Degrader-22, enabling targeted degradation of the BRD4 protein. Its applications include research in the field of protein degradation and regulation of gene expression, providing a valuable tool for studying the role of BRD4 in various biological processes.
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