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E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.
CRBN ligand-269 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, facilitating the formation of a PROTAC (proteolysis-targeting chimera). It serves as a valuable tool for research applications involving targeted protein degradation and the modulation of intracellular protein levels.
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CRBN ligand-766 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), utilized to facilitate the recruitment of the CRBN protein. This compound can be conjugated with a ligand targeting a specific protein through a linker, enabling the development of proteolysis-targeting chimeras (PROTACs). Its application in targeted protein degradation research provides a strategic approach for modulating protein levels within cellular systems.
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Desamino lenalidomide-cyano is a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound is utilized to recruit the cereblon protein, enabling targeted protein degradation. Desamino lenalidomide-cyano can be conjugated with a target protein ligand through a linker to create a PROTAC, facilitating innovative research in targeted therapeutics and protein regulation.
CRBN ligand-523 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be utilized in the design of PROTACs (proteolysis targeting chimeras) by linking it to a target protein ligand through a suitable linker. Research applications include targeted protein degradation studies and the exploration of novel therapeutic strategies in cancer and beyond.
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CRBN ligand-541 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound can be effectively coupled with a target protein ligand through a linker, enabling the development of a PROTAC (proteolysis-targeting chimera). It is widely utilized in research applications focused on targeted protein degradation and the modulation of cellular protein levels.
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CRBN ligand-327 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to targeted proteins. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling targeted degradation of specific proteins. It serves as a valuable tool for research in protein homeostasis and therapeutic development in cancer and other diseases.
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CRBN Ligand-431 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). It serves as a valuable tool for studying targeted protein degradation and understanding protein regulation pathways in various biological contexts.
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CRBN ligand-516 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of PROTACs (PROteolysis TArgeting Chimeras). CRBN ligand-516 is valuable for research applications aimed at exploring targeted protein degradation and the therapeutic potential of modulating ubiquitin-proteasome pathways.
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CRBN ligand-582 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling the creation of proteolysis-targeting chimeras (PROTACs). This compound is valuable for research in targeted protein degradation and can be utilized in the development of novel therapeutic strategies.
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7-F-4-I-Desamino lenalidomide acts as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of cereblon to target proteins, enabling the development of proteolysis-targeting chimeras (PROTACs). It is a valuable tool for research in targeted protein degradation and the study of protein interactions within cellular pathways.
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CRBN ligand-715 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound is designed to create proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands through a suitable linker. CRBN ligand-715 is valuable in studies involving targeted degradation of specific proteins, providing insights into cellular regulation and therapeutic interventions.
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CRBN ligand-666 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be utilized in PROTAC (proteolysis-targeting chimeras) approaches, enabling targeted protein degradation for research in cellular processes and therapeutic development. Its applications include studying the ubiquitin-proteasome system and exploring novel pathways for disease intervention.
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CRBN ligand-390 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating targeted protein degradation. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera). Its application in research enables the modulation of protein functions and the investigation of protein degradation pathways.
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CRBN ligand-282 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon protein. This compound can be conjugated to target protein ligands through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras) to promote targeted protein degradation. Its utility in drug discovery and development makes it a vital tool for studying protein regulation and degradation pathways.
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CRBN ligand-486 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It serves as a key component in the development of proteolysis-targeting chimeras (PROTACs) by facilitating the recruitment of CRBN to target proteins. This reagent is instrumental in cellular studies aimed at understanding protein degradation pathways and has potential applications in targeted protein modulation for therapeutic purposes.
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CRBN ligand-611 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this essential protein. It is designed to be conjugated to target protein ligands through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). This compound is valuable for studies focused on targeted protein degradation and E3 ligase-mediated pathways in cellular biology.
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CRBN ligand-656 is an E3 ubiquitin ligase ligand that specifically recruits the cereblon (CRBN) protein. It serves as a critical component in the development of PROTACs by linking to target protein ligands through a spacer or linker. This functionality enables selective degradation of target proteins, facilitating research in protein regulation and therapeutic interventions in diverse biological systems.
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CRBN ligand-688 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment to target proteins. This compound can be utilized in the design of PROTACs (Proteolysis Targeting Chimeras) by linking it to a target protein ligand via a suitable linker. CRBN ligand-688 is valuable for research applications focused on targeted protein degradation and the exploration of synthetic biology pathways.
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CRBN ligand-492 is a ligand specifically designed for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits the cereblon protein, facilitating the development of proteolysis-targeting chimeras (PROTACs) when conjugated with a target protein ligand through a linker. CRBN ligand-492 is valuable for researchers exploring targeted protein degradation and the modulation of protein homeostasis in various biological contexts.
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CRBN ligand-742 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand using a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-742 is utilized in research focused on targeted protein degradation, offering the potential to develop novel therapeutic strategies through the modulation of protein homeostasis.
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E3 Ligase Ligand 59 is a selective ligand for E3 ubiquitin ligases, particularly FDU73. This compound facilitates the development of PROTACs (proteolysis targeting chimeras) that harness the ubiquitin-proteasome pathway for targeted protein degradation. Its unique properties make it a valuable tool for studying protein regulation and cellular pathways in chemical biology research.
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CRBN ligand-252 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound is integral for the development of PROTACs (proteolysis-targeting chimeras), allowing for targeted protein degradation in therapeutic applications. CRBN ligand-252 is a valuable tool for researchers investigating ubiquitin-mediated proteolysis and its implications in various biological processes and disease states.
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CRBN ligand-268 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-268 is valuable for research applications in targeted protein degradation and therapeutic development.
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CRBN ligand-409 is a small molecule that targets the E3 ubiquitin ligase cereblon (CRBN). It is designed to facilitate the recruitment of CRBN to specific target proteins, enabling the targeted degradation of those proteins through the PROTAC technology platform. This compound is valuable for researchers investigating protein regulation, degradation pathways, and therapeutic applications in diseases involving dysregulated protein levels.
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CRBN ligand-546 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera), which enables the targeted degradation of specific proteins. It is valuable for research in targeted protein degradation and cellular regulation mechanisms.
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