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E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.
Desamino lenalidomide-4-Br-7-OH acts as a ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of cereblon to target proteins, enabling the development of PROTACs (proteolysis-targeting chimeras) for targeted protein degradation. This compound is significant for research applications focused on protein homeostasis and therapeutic strategies involving targeted protein removal.
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CRBN ligand-670 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. It is valuable for research applications involving modulation of protein levels and investigation of CRBN's role in various cellular processes.
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CRBN ligand-567 is a ligand designed to target the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment to specific proteins. This compound is essential for the development of PROTACs (proteolysis-targeting chimeras), which harness the ubiquitin-proteasome system to promote the targeted degradation of proteins. Its unique properties make CRBN ligand-567 a valuable tool for researchers investigating protein regulation and degradation pathways.
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(S)-Thalidomide-5-OH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, thereby enabling the formation of a PROTAC (proteolysis-targeting chimaera). It serves as a valuable tool in drug discovery and development, particularly in the context of targeted protein degradation strategies.
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CRBN ligand-601 is an E3 ubiquitin ligase cereblon (CRBN) ligand that functions by selectively recruiting the cereblon protein. This compound can be effectively conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). It serves as a valuable tool for research applications involving targeted protein degradation, providing insights into protein regulation and potential therapeutic strategies.
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CRBN ligand-593 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits the CRBN protein and can be conjugated to a target protein ligand through a linker to create a PROTAC. Its unique mechanism allows for precise modulation of protein degradation pathways, making it valuable for research in targeted protein degradation and related therapeutic applications.
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(S,R,S)-AHPC-PEG5-Azide is a VHL ligand that specifically targets the von Hippel-Lindau (VHL) protein. This compound serves as a pivotal component for the formation of PROTACs (proteolysis-targeting chimeras) by facilitating the recruitment of E3 ligases to target proteins. Its utility in targeted protein degradation research makes it invaluable for studies focused on regulating protein levels and functions in cellular environments.
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CRBN ligand-642 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC). It is valuable for research applications focused on targeted protein degradation and uncovering cellular pathways associated with ubiquitination.
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CRBN ligand-438 is a ligand for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits the CRBN protein, facilitating the targeted degradation of specific proteins. This compound can be conjugated to a target protein ligand via a linker, enabling the formation of Proteolysis Targeting Chimeras (PROTACs) for applications in targeted protein degradation research.
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CRBN ligand-560 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the development of PROTACs (Proteolysis Targeting Chimeras), enabling targeted degradation of specific proteins via the ubiquitin-proteasome pathway. Its applications extend to cancer research and drug discovery, where modulation of protein levels is critical for therapeutic intervention.
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Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph is a ligand targeting E3 ubiquitin ligase, an essential component of the ubiquitin-proteasome pathway. This compound is designed for use in research applications involving protein degradation and modulation of cellular processes. It can be conjugated to other ligands via a linker to create more complex structures, such as 22-SLF, facilitating the study of E3 ligase interactions and functions.
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CRBN ligand-879 is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the cereblon protein, enabling the formation of a PROTAC by linking to a target protein ligand through a suitable linker. CRBN ligand-879 is valuable in studies related to targeted protein degradation and therapeutic applications in the field of protein regulation.
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CRBN ligand-502 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a specific target protein ligand through a suitable linker. Its key applications include exploring targeted protein degradation and investigating the regulatory mechanisms of ubiquitin-mediated proteolysis in cellular pathways.
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CRBN ligand-384 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound enables the synthesis of proteolysis-targeting chimeras (PROTACs) by linking with specific target protein ligands through a suitable linker. CRBN ligand-384 is significant in studying targeted protein degradation and biodegradation pathways, making it a valuable tool for researchers investigating cellular regulation and therapeutic interventions.
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CRBN ligand-530 is a ligand for the cereblon (CRBN) E3 ubiquitin ligase that facilitates the recruitment of CRBN to target proteins. This compound is designed for the development of Proteolysis Targeting Chimeras (PROTACs), allowing targeted degradation of specific proteins through the ubiquitin-proteasome pathway. Its application is valuable in chemical biology and therapeutic research, particularly in studies involving targeted protein modulation.
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CRBN ligand-476 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed to be conjugated to a target protein ligand through a linker, enabling the development of proteolysis-targeting chimeras (PROTACs). Its application in targeted protein degradation provides a valuable tool for research in cellular regulation and therapeutic development.
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CRBN ligand-237 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It can be effectively utilized to link with a target protein ligand through a linker, enabling the formation of Proteolysis-Targeting Chimeras (PROTACs). This compound is valuable for research applications involving targeted protein degradation and the study of ubiquitin-mediated pathways.
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CRBN ligand-585 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). CRBN ligand-585 is valuable for studies involving targeted protein degradation and elucidating the role of E3 ligases in cellular processes.
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CRBN ligand-524 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for targeted protein degradation. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). CRBN ligand-524 is valuable for research applications that involve modulating protein levels and investigating cellular processes related to protein homeostasis.
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CRBN ligand-703 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN) and is utilized to recruit the CRBN protein effectively. This compound can be conjugated to target protein ligands through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). It serves as a valuable tool in chemical biology for the investigation of targeted protein degradation pathways and associated therapeutic applications.
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CRBN ligand-459 is a ligand targeting the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It serves as a crucial component in the development of PROTACs (Proteolysis Targeting Chimeras) by linking to a target protein ligand through a suitable linker. This compound is essential for studying targeted protein degradation mechanisms and advancing therapeutic strategies in various disease models.
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CRBN ligand-419 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN in targeted protein degradation applications. This compound can be conjugated with a ligand specific to a target protein through a linker, enabling the formation of potent PROTACs (Proteolysis Targeting Chimeras). It serves as a valuable tool for investigating the mechanisms of ubiquitination and the degradation of specific proteins in cancer research and drug discovery.
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CRBN ligand-370 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand using a linker, enabling the synthesis of proteolysis-targeting chimeras (PROTACs). It is valuable for research applications in protein degradation studies and novel therapeutic development.
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CRBN ligand-196 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein, enabling the targeted degradation of specific proteins through the formation of PROTACs (Proteolysis Targeting Chimeras). This reagent is pivotal for researchers studying targeted protein degradation and its therapeutic applications in various diseases.
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CRBN ligand-764 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the targeted recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand using a linker to create a Proteolysis Targeting Chimera (PROTAC). Its utility is primarily in research applications focused on targeted protein degradation and the study of ubiquitin-proteasome system mechanisms.
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