Ligand for Target Protein for PROTAC

Cat. No.

A60236

CAS No.

1326612-12-7

7α,25-Dihydroxycholesterol intermediate-1

7α,25-Dihydroxycholesterol intermediate-1 is a crucial synthetic intermediate in the production of 7α,25-Dihydroxycholesterol. This compound functions as a ligand for the orphan G protein-coupled receptor EBI2 (GPR183), playing a significant role in immune system regulation and cellular signaling pathways. Its applications extend to the development of PROTACs, enabling targeted protein degradation in research and therapeutic contexts.

Cat. No.

A65578

CAS No.

2762552-73-6

STING ligand-3

STING ligand-3 functions as a ligand for the target protein, enabling the control of PROTAC activity. This compound plays a critical role in the synthesis of anti-inflammatory agents, specifically Anti-inflammatory agent 70. Its application in chemical research can facilitate advancements in understanding inflammatory pathways and developing therapeutic strategies.

Cat. No.

A65763

CAS No.

3061690-80-7

HPK1 ligand-Linker Conjugate 1

HPK1 ligand-Linker Conjugate 1 is a synthesized ligand-linker conjugate designed for the development of PROTACs targeting HPK1. This compound serves as a critical component in the synthesis of PROTAC HPK1 Degrader-5, which exhibits significant anti-tumor activity and is characterized by its potency and oral bioavailability. Its applications extend to cell signaling research and targeted protein degradation strategies in cancer therapy studies.

Cat. No.

A65809

CAS No.

2581116-22-3

PD0325901-O-C2-dioxolane

PD0325901-O-C2-dioxolane is a derivative of the MEK inhibitor PD0325901, designed as a ligand for targeted protein degradation in conjunction with VHL or CRBN E3 ligases. This compound facilitates the synthesis of MEK1/2 degraders, enabling the selective degradation of MEK proteins in experimental studies. Its application in research provides critical insights into MEK-related signaling pathways and their role in various diseases, particularly in cancer biology.

Cat. No.

A65824

CAS No.

212631-56-6

MEK ligand-2

MEK ligand-2 is a ligand specifically designed for PROTAC applications targeting MEK1 and MEK2 proteins. This compound serves as a vital component for the development of the MS934 PROTAC, facilitating the degradation of MEK1 and MEK2 via a VHL-recruiting mechanism. It plays a crucial role in research aimed at understanding the regulation of MAPK signaling pathways and potential therapeutic strategies in cancer biology.

Cat. No.

A65864

CAS No.

3027977-34-7

PROTAC SOS1 ligand 1

PROTAC SOS1 ligand 1 is a high-affinity ligand for the SOS1 protein, facilitating targeted protein degradation through PROTAC technology. This compound is instrumental in the development of therapeutic strategies by enabling the selective modulation of SOS1, which plays a pivotal role in various oncogenic signaling pathways. Researchers can utilize this reagent in studies focused on cancer biology and drug discovery, particularly in exploring novel approaches to target and degrade specific proteins associated with tumor progression.

Cat. No.

A75757

CAS No.

3048196-74-0

IDO1 ligand-1

IDO1 ligand-1 is a specific ligand that interacts with the IDO1 protein, facilitating targeted protein degradation through the PROTAC mechanism. This compound is instrumental in research focused on IDO1 modulation, which has implications in oncology and immunology. By effectively promoting the degradation of IDO1, IDO1 ligand-1 serves as a valuable tool for investigating the therapeutic potential of PROTACs in various biological contexts.

Cat. No.

A79473

CAS No.

2052306-12-2

TBK1 ligand 2-C-O-C4-O-C3-O-C-amide

TBK1 ligand 2-C-O-C4-O-C3-O-C-amide is a protein ligand-linker conjugate specifically designed to facilitate the development of targeted protein degraders. This compound serves as a crucial component in the synthesis of the PROTAC TBK1 degrader-2, enabling selective degradation of the TBK1 protein. Its application in chemical biology research allows for the investigation of TBK1's role in various cellular processes and the potential modulation of its activity.

Cat. No.

A79524

CAS No.

3082764-64-2

Nrf2 activator-22

Nrf2 activator-22 is a ligand specifically targeting the Nrf2 protein, playing a crucial role in the development of PROTAC-based therapeutics. This compound facilitates the synthesis of PROTAC K-Ras Degrader-7, highlighting its potential in targeted protein degradation research. Nrf2 activator-22 is valuable for studies aimed at manipulating oxidative stress responses and related signaling pathways.

Cat. No.

A79856

CAS No.

2769753-45-7

PI3Kγ ligand 1

PI3Kγ ligand 1 is a selective ligand for phosphoinositide 3-kinase gamma (PI3Kγ), utilized in the development of proteolysis-targeting chimeras (PROTACs). This compound effectively engages with PI3Kγ, facilitating targeted protein degradation. Its biological activity makes it valuable for research applications in cancer therapeutics and immunology, particularly in elucidating PI3K signaling pathways.

Cat. No.

A81258

CAS No.

2154342-61-5

Thalidomide-5-piperazine

Thalidomide-5-piperazine is a ligand designed for protein-targeted degradation utilizing the PROTAC technology. This compound facilitates the recruitment of E3 ubiquitin ligases to specific target proteins, promoting their ubiquitination and subsequent proteasomal degradation. It is primarily used in research applications focused on studying protein function and modulation within cellular pathways.

Cat. No.

A81267

CAS No.

2484741-78-6

CBP/p300 ligand 2

CBP/p300 ligand 2 is a selective ligand targeting the dCBP-1 protein, facilitating its role as a heterobifunctional degrader of the p300/CBP proteins. This compound is essential for research applications focused on targeted protein degradation, enabling the study of p300/CBP's involvement in various biological processes and diseases. Its utility in PROTAC development makes it a valuable tool for investigating therapeutic strategies in cancer and other disorders linked to aberrant p300/CBP activity.

Cat. No.

A81269

CAS No.

2467965-71-3

EED226-COOH

EED226-COOH is an EED226-derived ligand that targets the EED protein, facilitating the formation of PROTACs. This compound effectively binds to a VHL ligand through a linker, leading to the degradation of the PRC2 complex. EED226-COOH is valuable for research applications focused on targeted protein degradation and studying the roles of PRC2 in various biological processes.

Cat. No.

A81270

CAS No.

1001382-14-4

Ipatasertib-NH2

Synonyms: GDC-0068-NH2; RG7440-NH2

Ipatasertib-NH2 is a targeted ligand for the protein AKT, functioning as a key component in PROTAC-mediated degradation systems, specifically in INY-03-041. This compound is structured with a ten-hydrocarbon linker and the CRBN ligand Lenalidomide, enabling selective recruitment of E3 ubiquitin ligase for targeted protein degradation. Its utility in research includes elucidating AKT's role in cellular signaling and developing novel therapeutic strategies.

Cat. No.

A81271

CAS No.

2769753-10-6

TAE648

TAE648 is a ligand specifically designed for target proteins involved in PROTAC (Proteolysis Targeting Chimeras) research. This compound plays a crucial role in the synthesis of PROTAC SK-3-91, facilitating targeted degradation of specific proteins. Its applications span various areas of chemical biology and drug discovery, advancing studies in protein modulation and therapeutic development.

Cat. No.

A81274

CAS No.

2366269-23-8

Palbociclib-propargyl

Synonyms: PROTAC CDK6 ligand 1

Palbociclib-propargyl is a selective ligand for CDK6, designed for use in PROTAC applications. This compound functions through a PEG linker to effectively bind to the CRBN ligand, forming the PROTAC CP-10, which exhibits a DC50 of 2.1 nM for CDK6. Additionally, Palbociclib-propargyl features an alkyne group making it suitable for click chemistry, specifically allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-bearing molecules. This reagent is valuable for advancing research in targeted protein degradation and cancer therapeutics.

Cat. No.

A81275

CAS No.

2955618-24-1

(S)-SKBG-1

(S)-SKBG-1 is a covalent ligand designed for targeting specific proteins in the context of PROTAC applications. Though classified as inactive, it serves an essential role as an assay control to help validate experimental conditions and results. This compound is valuable for researchers investigating the mechanisms of protein degradation and the development of targeted therapeutic strategies.

Cat. No.

A81276

CAS No.

2685873-44-1

Tazemetostat de(methyl morpholine)-COOH

Tazemetostat de(methyl morpholine)-COOH is a ligand specifically designed for the target protein EZH2, facilitating the synthesis of EZH2 degraders for the PROTAC approach. This compound exhibits significant biological activity by effectively inhibiting cell viability in diffuse large B-cell lymphoma (DLBCL) and various lymphoma subtypes. It serves as a valuable tool for researchers investigating targeted protein degradation and its therapeutic potential in oncology.

Cat. No.

A81277

CAS No.

1339378-93-6

SMARCA2/4-IN-2

SMARCA2/4-IN-2 is a ligand specifically designed for the SMARCA2 and SMARCA4 proteins, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound serves as a critical component in the synthesis of PROTAC SMARCA2/4-degrader-5, enabling targeted degradation of these chromatin remodelers. SMARCA2/4-IN-2 is valuable for research applications in cancer biology and therapeutic development focused on modulation of epigenetic regulators.

Cat. No.

A81279

CAS No.

1264754-13-3

PROTAC ERRα ligand 1

PROTAC ERRα ligand 1 is an orally active inverse agonist targeting ERRα with an IC50 of 0.6 μM. This compound demonstrates selective inhibition, as it exhibits minimal activity against a range of other nuclear receptors, including ERαc, ERRγ, ERβ, PPARα, PPARγ, PPARδ, and RXRα. PROTAC ERRα ligand 1 is valuable for research in metabolic diseases, such as type 2 diabetes and obesity, and has shown potential in enhancing insulin sensitivity in vivo.

Cat. No.

A81280

CAS No.

2448414-41-1

PROTAC BRD9-binding moiety 1 hydrochloride

PROTAC BRD9-binding moiety 1 hydrochloride is a ligand that selectively binds to the bromodomain protein BRD9, facilitating its targeted degradation through the PROTAC (Proteolysis Targeting Chimeras) mechanism. This compound is instrumental in research focusing on protein degradation pathways and the modulation of BRD9-associated functions in various biological contexts, such as cancer and inflammation. It serves as a valuable tool for studying the therapeutic potential of targeting BRD9 in disease models.

Cat. No.

A81282

CAS No.

2460248-49-9

BRD9 ligand-6

BRD9 ligand-6 serves as a ligand for the BRD9 target protein, facilitating the development of PROTAC (Proteolysis Targeting Chimeras) compounds. This reagent exhibits specific binding properties that enable the selective degradation of target proteins in cellular models. It is particularly valuable in research applications focused on targeted protein degradation and therapeutic intervention strategies.

Cat. No.

A81283

CAS No.

1936431-36-5

Piperidine-GNE-049-N-Boc

Piperidine-GNE-049-N-Boc is a ligand that targets the dCBP-1 protein, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound serves as a potent and selective heterobifunctional degrader for the transcriptional co-activators p300 and CBP. It is applicable in research aimed at understanding protein degradation mechanisms and the modulation of gene expression.

Cat. No.

A81284

CAS No.

2375354-13-3

Demethyl-RSL3

Demethyl-RSL3 functions as a ligand for targeted protein degradation through the proteolysis targeting chimera (PROTAC) mechanism. This compound effectively modulates cellular pathways by inducing degradation of specific proteins. Its applications lie primarily in cancer research and the development of novel therapeutic strategies aimed at improving targeted protein degradation efficacy.

Cat. No.

A81285

CAS No.

1603845-36-8

PROTAC Her3-binding moiety 1

PROTAC Her3-binding moiety 1 is a ligand designed to selectively target the HER3 protein, facilitating its degradation via the PROTAC (PROteolysis TArgeting Chimeras) technology. This compound plays a critical role in modulating HER3 activity, which is implicated in various cancer pathways. Its application in research includes studying HER3 signaling and developing targeted therapies for HER3-expressing malignancies.