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Neuropeptide FF receptor ligands act on two peptide receptors that modulate pain and opioid responses. Neuropeptide FF (NPFF) and related peptides end in an Arg-Phe-amide (RFamide) motif. Two G protein-coupled receptors for NPFF, NPFF1 and NPFF2, were identified in 2000. NPFF binds both receptors with nanomolar affinity, slightly more tightly to NPFF2. The system is studied in pain processing, opioid tolerance and hormone regulation. RF9, reported in 2006 as a selective NPFF receptor antagonist, prevented opioid-induced hyperalgesia and tolerance in rodents. The category lists Neuropeptide FF, RFRP-3(human) and Neuropeptide AF (cattle), the NPFF2 activator AC-263093 free base and the antagonists RF9 and DP32.
NPFFR2 modulator-1 is a selective modulator of the neuropeptide FF receptor 2 (NPFFR2). This compound influences various signaling pathways associated with pain modulation and may provide insights into neuroinflammatory responses. It is valuable for researchers investigating neuropeptide interactions and their roles in pain perception and related disorders.
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