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RXFP Receptor

RXFP receptor agonists act on the four relaxin family peptide receptors, RXFP1 to RXFP4. Relaxin family peptide receptors (RXFP) are G protein-coupled receptors (GPCRs) for relaxin and insulin-like peptides. In 2002, the orphan leucine-rich repeat-containing G protein-coupled receptors 7 and 8 (LGR7, LGR8) were shown to respond to relaxin; they are now RXFP1 and RXFP2. RXFP3 is the receptor for relaxin-3, and RXFP4 binds insulin-like peptide 5. ML-290, reported in 2013, is a small-molecule RXFP1 agonist identified by high-throughput screening. B7-33 is a single-chain peptide derived from relaxin that activates RXFP1. AZD5462 is listed as an RXFP1 modulator, and A13:B7-24-GG is an RXFP4 agonist.

1 Item

  • AZD5462
    Cat. No.
    A63819
    CAS No.
    2787501-83-9

    AZD5462

    AZD5462 is an RXFP1 modulator that targets the relaxin receptor, which is part of the GPCR family. This compound exhibits anti-fibrotic and anti-inflammatory properties, making it a valuable tool for research into heart failure and related cardiovascular diseases. Its application in studies of RXFP1 signaling pathways can provide insights into potential therapeutic strategies for heart dysfunction.

    In stock View Details
    1 mg
    $230.00
    5 mg
    $645.00
    All 6 sizes

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