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Guanylate Cyclase

Guanylate cyclase stimulators and activators act on the enzymes that make the second messenger cGMP. These enzymes convert guanosine triphosphate into cyclic guanosine monophosphate (cGMP). Soluble guanylate cyclase (sGC) is the main receptor for nitric oxide (NO), whereas membrane-bound guanylate cyclase C (GC-C) binds peptide ligands. In 1990 GC-C was identified as the receptor for the heat-stable enterotoxin of Escherichia coli. BAY 41-2272 was described in 2001 as acting on an NO-independent regulatory site of sGC. Riociguat, vericiguat and praliciguat are further sGC stimulators, and YC-1 is an earlier sGC activator. Linaclotide is a peptide GC-C agonist used in studies of intestinal fluid secretion.

1 Item

  • MCUF-651
    Cat. No.
    A60865
    CAS No.
    2747162-85-0

    MCUF-651

    MCUF-651 is a positive allosteric modulator of the guanylyl cyclase A receptor (GC-A), exhibiting a binding affinity (KD) of 397 nM. This compound selectively enhances the interaction of atrial natriuretic peptide (ANP) with GC-A, leading to increased cGMP production in human cardiac, renal, and adipose tissues. Additionally, MCUF-651 demonstrates the ability to inhibit cardiomyocyte hypertrophy, making it a valuable tool for research in cardiovascular and metabolic pathways.

    In stock View Details
    1 mg
    $45.00
    5 mg
    $105.00
    All 6 sizes

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