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G Protein

G protein reagents here range from guanine nucleotides to ligands for orphan G protein-coupled receptors. Heterotrimeric G proteins consist of a Gα subunit, which binds guanine nucleotides, and a tightly associated Gβγ dimer. An activated G protein-coupled receptor (GPCR) exchanges guanosine diphosphate (GDP) for guanosine triphosphate (GTP) on Gα, which then separates from Gβγ. Guanosine 5'-triphosphate trisodium salt is listed as a G protein activator, but most other compounds act on less studied receptors. G15 blocks the G protein-coupled estrogen receptor (GPER, also called GPR30), and CID16020046 antagonizes G protein-coupled receptor 55 (GPR55). Kynurenic acid, an endogenous tryptophan metabolite, is listed as a GPR35 agonist. GTPase-accelerating proteins that end the signal are covered in RGS Protein.

2 Items

  • α,δ-NAG
    Cat. No.
    A36386
    CAS No.
    3051899-13-6

    α,δ-NAG

    α,δ-NAG is an allosteric modulator targeting G protein-coupled receptors (GPCRs). This orally active derivative of L-Glutamine is resistant to glutaminase activity and exhibits less hydrolysis, making it a valuable tool in the study of inflammatory responses. α,δ-NAG effectively suppresses neutrophilic airway inflammation by activating the GPCR/ERK/MKP-1 signaling pathway. This compound is useful for research applications in inflammation and immunology, particularly in conditions such as asthma.

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  • Arazine
    Cat. No.
    A57708
    CAS No.
    135304-07-3

    Arazine

    Synonyms: N-Acetyl-S-farnesyl-L-cysteine

    Arazine (N-Acetyl-S-farnesyl-L-cysteine) acts as a cell-permeable modulator of G protein and G-protein coupled receptor signaling. By competing with prenylated G proteins or their receptors, Arazine serves as a substrate for isoprenylcysteine methyltransferase, influencing downstream signaling pathways. This compound is valuable in the study of G protein signaling mechanisms and its implications in various cellular processes.

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    1 mg
    $85.00
    All 1 sizes

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