Bradykinin Receptor

Bradykinin receptor agonists and antagonists act on B1 and B2, two G protein-coupled kinin receptors. Kinin peptides such as bradykinin are released from kininogens by kallikreins and regulate vascular tone, permeability and pain signaling. The B2 receptor is expressed constitutively in many tissues, and the human receptor was cloned in 1992. The B1 receptor, cloned in 1994, is induced by tissue injury and inflammation and prefers des-Arg kinin metabolites. A 2005 International Union of Pharmacology (IUPHAR) review set out this classification of the kinin receptor family. Icatibant is a peptide B2 antagonist, and FR167344 free base is a nonpeptide B2 antagonist. R715 and SSR240612 block the B1 receptor, while Lys-[Des-Arg9]Bradykinin TFA acts as a B1 agonist.

4 Items

  • Bradykinin (1-7)
    Cat. No.
    A59125

    Bradykinin (1-7)

    Synonyms: Bradykinin Fragment 1-​7

    Bradykinin (1-7) is an amino-truncated variant of the peptide Bradykinin, functioning as a modulator of bradykinin receptors. This metabolite, generated through cleavage by endopeptidase, exhibits significant biological activity in modulating inflammatory responses and vascular functions. It is widely utilized in research focusing on cardiovascular diseases, pain mechanisms, and inflammatory pathways.

    5 mg
    $50.00
    10 mg
    $85.00
    All 4 sizes
  • Bradykinin (1-6)
    Cat. No.
    A59129

    Bradykinin (1-6)

    Bradykinin (1-6) is a truncated peptide variant of the inflammatory mediator bradykinin that targets bradykinin receptors. It serves as a stable metabolite, generated through the action of carboxypeptidase Y (CPY). This compound is essential for studies involving pain, inflammation, and vascular permeability, providing insights into the role of bradykinin in physiological and pathophysiological processes. Bradykinin (1-6) is particularly useful in research applications exploring receptor signaling and modulation in various biological systems.

    5 mg
    $100.00
    10 mg
    $165.00
    All 2 sizes
  • Bradykinin (1-3)
    Cat. No.
    A59140

    Bradykinin (1-3)

    Bradykinin (1-3) is a truncated peptide derived from bradykinin, consisting of three amino acid residues. Acting as a bradykinin receptor modulator, it plays a role in various physiological processes, including vasodilation and pain regulation. This reagent is primarily utilized in research applications focused on studying the bradykinin signaling pathway and its implications in inflammatory responses and cardiovascular health.

    5 mg
    $60.00
    10 mg
    $80.00
    All 3 sizes
  • Bradykinin triacetate
    Cat. No.
    A59165

    Bradykinin triacetate

    Bradykinin triacetate is a bradykinin receptor modulator that functions as an endothelium-dependent vasodilator, effectively lowering blood pressure. This compound induces contraction in bronchial and intestinal non-vascular smooth muscle, increases vascular permeability, and plays a crucial role in pain mechanisms. It is valuable for research in cardiovascular and respiratory physiology, as well as studies related to vascular biology and pain signaling pathways.

    Out of stock

    All 3 sizes

4 Items

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