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Neurokinin Receptors

Neurokinin receptor antagonists block the tachykinin receptors activated by substance P, neurokinin A and neurokinin B. The three subtypes, neurokinin 1, 2 and 3 receptors (NK1, NK2, NK3), are G protein-coupled receptors with different preferred ligands. Their cloning in the late 1980s began with the bovine NK2 receptor and the rat NK1 receptor. Substance P binds NK1 with the highest affinity, and this receptor is studied in emesis, pain transmission and neurogenic inflammation. Most compounds here are NK1 antagonists, including aprepitant, its phosphate prodrug fosaprepitant, rolapitant and netupitant. Ibodutant is a selective NK2 receptor antagonist used to study smooth muscle contraction in the gut.

2 Items

  • Biotin-Substance P
    Cat. No.
    A61986
    CAS No.
    87468-58-4

    Biotin-Substance P

    Biotin-Substance P is a biotinylated form of the neuropeptide Substance P, which primarily targets the neurokinin 1 receptor (NK1R). This compound acts as both a neurotransmitter and neuromodulator within the central nervous system (CNS), playing a crucial role in pain perception, stress response, and neuroinflammation. Biotin-Substance P is particularly useful in research applications focused on neurokinin receptor signaling pathways and neuropeptide interactions in various physiological and pathological conditions.

    In stock View Details
    5 mg
    $205.00
    10 mg
    $315.00
    All 3 sizes
  • (Rac)-LM11A-31
    Cat. No.
    A62125
    CAS No.
    289475-77-0

    (Rac)-LM11A-31

    (Rac)-LM11A-31 is a racemate that serves as a non-peptide modulator of the p75 neurotrophin receptor (p75NTR). This compound functions as an antagonist to proNGF, significant in studies related to neurodegenerative diseases and neuronal survival. Its oral efficacy provides a valuable tool for research applications aimed at understanding neurotrophic signaling pathways and developing therapeutic strategies.

    In stock View Details
    500 mg
    $1,225.00
    All 1 sizes

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