Adrenergic Receptors

Cat. No.

A29735

CAS No.

2220235-94-7

CYD-1-79

CYD-1-79 is a selective positive allosteric modulator of the 5-HT2C receptor. This compound enhances 5-HT-induced intracellular calcium release through a distinct allosteric site, demonstrating significant inhibition at dopamine D3 receptors, DAT, and α2A/α2B adrenergic receptors. CYD-1-79 has been shown to modulate spontaneous ambulation in rodents and can synergize with low doses of 5-HT2C receptor agonists. Additionally, it reduces relapse vulnerability in models of psychoactive substance self-administration, highlighting its potential applications in neurological disease research.

Cat. No.

A29936

CAS No.

92589-98-5

Ipsapirone hydrochloride

Synonyms: TVX Q 7821

Ipsapirone hydrochloride is a selective modulator of the 5-HT1A receptor, functioning primarily as a partial agonist. This compound demonstrates anxiolytic properties, making it relevant for research in anxiety disorders. At elevated concentrations, ipsapirone hydrochloride can also exhibit antagonistic effects on the 5-HT1A receptor and inhibit 5-HT2 and α1-adrenergic receptor activities, expanding its applicability in pharmacological studies of serotonergic and adrenergic signaling pathways.

Cat. No.

A58140

CAS No.

391920-32-4

Lubabegron

Synonyms: LY-488756

Lubabegron is a potent modulator of β-adrenergic receptors (β-AR). It exhibits antagonistic activity at the β1 and β2 receptor subtypes while acting as an agonist for the β3 receptor subtype in cattle. This compound is effective in reducing ammonia gas emissions from livestock and their waste, making it relevant for environmental and agricultural research applications. Lubabegron holds potential for studies focusing on animal physiology and sustainable farming practices.

Cat. No.

A58280

CAS No.

23971-42-8

Meranzin

Meranzin is an adrenergic receptor modulator derived from the Traditional Chinese Medicine Chaihu-Shugan-San (CSS), isolated from the leaves of Murraya exotica L. It primarily regulates the alpha 2-adrenoceptor and influences the AMPA-ERK1/2-BDNF signaling pathway. Meranzin exhibits potential beneficial effects in preventing the co-occurrence of atherosclerosis and depression, making it a valuable tool for research in neurovascular health and related disorders.

Cat. No.

A58454

CAS No.

2816062-15-2

AP-7-168

AP-7-168 is a β-arrestin-biased negative allosteric modulator of the β2-adrenergic receptor (β2AR). It functions by promoting β2AR homodimerization and inhibiting GRK5-mediated phosphorylation, thereby sustaining bronchorelaxation in both cell and tissue models. This compound is particularly valuable for research in inflammation and immunology, including studies related to asthma and other respiratory conditions.

Cat. No.

A58670

CAS No.

1214645-87-0

Arrestin-3 modulator-1

Arrestin-3 modulator-1 is a selective modulator that interacts with arrestin-3 at the interdomain interface. This compound enhances the recruitment of arrestin-3 to phosphorylation-deficient β2-adrenergic receptors, as evidenced by increased Förster resonance energy transfer (FRET) levels in cellular assays. Arrestin-3 modulator-1 is valuable for studying congenital disorders such as retinal degeneration, hyperthyroidism, and obesity, offering insights into the molecular mechanisms underlying these conditions.

Cat. No.

A58850

CAS No.

161905-64-2

α1 adrenoceptor-MO-1

α1 adrenoceptor-MO-1 is an S enantiomer that selectively targets the alpha-1 adrenergic receptor. This compound exhibits alpha-lytic activity and demonstrates analgesic properties, making it more effective than its R enantiomer counterpart. α1 adrenoceptor-MO-1 is suitable for research applications focused on adrenergic signaling and pain modulation.

Cat. No.

A58857

CAS No.

130783-39-0

GP2-114

GP2-114 is a selective adrenergic receptor modulator that exhibits current-dependent cardiovascular effects. It is utilized in experimental models to study the physiological impacts on cardiovascular function and adrenergic signaling pathways. The compound offers valuable insights into the role of adrenergic receptors in cardiovascular responses, supporting various research applications in pharmacology and cardiovascular physiology.

Cat. No.

A84964

CAS No.

391926-19-5

Lubabegron fumarate

Synonyms: LY-591281; LY-488756 fumarate

Lubabegron fumarate is a selectiveβ-adrenergic receptor (β-AR) modulator, exhibiting antagonistic properties at both β1 and β2 receptor subtypes while acting as an agonist at the β3 subtype in bovine species. This compound effectively reduces ammonia (NH3) gas emissions from livestock and their waste, making it a valuable tool for improving environmental sustainability in agricultural practices. Lubabegron fumarate is primarily used in research applications focused on animal health and emissions management.

Cat. No.

A96786

CAS No.

36981-91-6

Fepradinol

Fepradinol is a drug derivative that primarily acts as a selective modulator of adrenergic receptors. This compound exhibits significant biological activity in influencing cardiovascular responses and can be utilized in research focused on cardiovascular pharmacology. Its modulatory effects make it valuable for investigating the therapeutic potential in treating various cardiovascular disorders.