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NPY Receptor

NPY receptor antagonists act on the Y1, Y2, Y5 and related receptors for neuropeptide Y (NPY). Neuropeptide Y was isolated from brain in 1982 as a peptide related to peptide tyrosine tyrosine (PYY) and pancreatic polypeptide. Its receptors are G protein-coupled receptors that regulate feeding, anxiety, vascular tone and neurotransmitter release. In 1996 a Y5 subtype was cloned and implicated in NPY-induced food intake. BIIE 0246 and JNJ-31020028 are Y2 receptor antagonists, and BMS-193885 blocks the Y1 receptor. L 152804 and CGP71683 hydrochloride are antagonists of the Y5 receptor subtype. The list also holds galanin receptor ligands, such as Galanin (1-30) (human) and HT-2157, and the natriuretic peptide nesiritide.

2 Items

  • CYM 2503
    Cat. No.
    A22092
    CAS No.
    1308833-36-4

    CYM 2503

    CYM2503 is a positive allosteric modulator (PAM) of the GAL2 receptor that potentiates galanin-induced IP1 production in vitro.

    In stock View Details
    1 mg
    $25.00
    5 mg
    $65.00
    All 7 sizes
  • M40
    Cat. No.
    A62218
    CAS No.
    143896-17-7

    M40

    M40 is a galanin receptor modulator that functions as either an antagonist or a weak agonist, depending on the specific subtype of galanin receptor targeted. It exhibits biological activity in various regions of the brain, including the hypothalamus, hippocampus, and amygdala, as well as in the pancreas. M40 is relevant for research applications investigating the role of galanin signaling in neurobiology and metabolic functions.

    In stock View Details
    1 mg
    $785.00
    All 1 sizes

2 Items

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