Stem Cell Reprogramming & Differentiation

Cat. No.

A10199

CAS No.

252917-06-9

Laduviglusib (CHIR-99021)

Synonyms: GSK-3 Inhibitor XVI; CT 99021; CHIR-99021

CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.

Cat. No.

A10256

CAS No.

391210-10-9

Mirdametinib (PD0325901)

Synonyms: PD0325901

PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2.

Cat. No.

A11762

CAS No.

446859-33-2

RepSox (SJN 2511)

Synonyms: E-616452; SJN 2511; ALK 5 inhibitor

RepSox (SJN 2511) is a selective inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively).

Cat. No.

A10212

CAS No.

212631-79-3

PD184352 (CI-1040)

Synonyms: CI-1040

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.

Cat. No.

A10105

CAS No.

320-67-2

Azacitidine

Synonyms: 5-azacytidine; Mylosar; Ladakamycin; Vidaza

Azacitidine is a chemical analogue of the cytosine nucleoside used in DNA and RNA that is mainly used in the treatment of myelodysplastic syndrome (MDS).

Cat. No.

A11220

CAS No.

142273-20-9

Kenpaullone

Kenpaullone is a potent inhibitor of CDK inhibitor (IC50 values are 0.4, 0.68, 7.5, 0.85 µM for CDK1/cyclinB, CDK2/cyclinA, CDK2/cyclinE and CDK5/p25 respectively). Also inhibits GSK-3β and LCK (IC50 values are 0.23 and 0.47 µM respectively) Displays reduced activity for other kinases (IC50 values are 15, 20, 20, 9 µM for c-src, casein kinase 2, ERK1 and ERK2 respectively). Also Generates iPSCs. Displays antiproliferative properties.

Cat. No.

A11225

CAS No.

839707-37-8

Pluripotin (SC-1)

Synonyms: SC-1

The activity of Pluripotin (SC-1) is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.

Cat. No.

A11558

CAS No.

215543-92-3

SU-5402

SU-5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively).

Cat. No.

A12362

CAS No.

1118807-13-8

KY02111

KY02111 is a potent and selective Wnt signaling pathway inhibitor discovered by a cell-based screening, which promotes differentiation of hESCs/iPSCs to cardiomyocytes when used at the second stage of differenitation.

Cat. No.

A13627

CAS No.

912545-86-9

SAG

Synonyms: Smoothened Agonist

SAG is a chlorobenzothiophene-containing compound which acts as a SMO agonist (EC50 = 3 nM) but inhibits hedgehog signaling at high concentrations (>1 uM).

Cat. No.

A17323

CAS No.

99-66-1

Valproic acid

Synonyms: Depakin; Erganyl; Stavzor; Valproate

Valproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.

Cat. No.

A10852

CAS No.

156-54-7

Sodium butyrate

Sodium butyrate (NaB, Butanoic acid sodium salt), sodium salt of butyric acid, is a histone deacetylase inhibitor and competitively binds to the zinc sites of class I and II histone deacetylases (HDACs).

Cat. No.

A10855

CAS No.

1069-66-5

Valproic acid sodium salt

Synonyms: Sodium Valproate

Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2.

Cat. No.

A10944

CAS No.

302-79-4

Tretinoin (Retinoic acid)

Synonyms: Retinoic Acid; ATRA; Vitamin A Acid

Tretinoin is an endogenous agonist for retinoic acid receptors with IC50 value of 14 nM for RAR-alpha, RAR-beta and RAR-gamma receptors).

Cat. No.

A11763

CAS No.

935693-62-2

BIX 01294

BIX 01294 is a G9a-like protein and G9a histone lysine methyltransferase inhibitor.

Cat. No.

A12469

CAS No.

1160927-48-9

IDE1

IDE1 is a potent cell-permeable definitive endoderm formation inducer (EC50 = 125 nM, ESC) similar to IDE 2.

Cat. No.

A12899

CAS No.

91396-88-2

PluriSln 1

stearoyl-CoA desaturase 1 (SCD1) inhibitor. Used to selectively eliminate undifferentiated human pluripotent stem cells (hPSCs) from culture; induces ER stress, attenuates protein synthesis and induces apoptosis in hPSCs. Prevents teratoma formation in immunocompromised mice.

Cat. No.

A13007

CAS No.

71441-28-6

TTNPB

Synonyms: Arotinoid acid; Ro 13-7410

TTNPB enhances reprogramming efficiency in chemically induced pluripotent stem cells (CiPSCs).

Cat. No.

A13192

CAS No.

687561-60-0

IWP-3

Synonyms: IWP 3,IWP3

IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC?????€ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC?????€ = 1.2 μM).

Cat. No.

A13358

CAS No.

1986-47-6

Tranylcypromine hydrochloride

Synonyms: 2-PCPA

Tranylcypromine hydrochloride is a non-selective MAO-A/B inhibitor.

Cat. No.

A15773

CAS No.

671225-39-1

Cardiogenol C

Cardiogenol C is a potent and cell permeable inducer of embryonic stem cell differentiation in cardiomyocytes displaying an Ec50 of 100nm.

Cat. No.

A15774

CAS No.

832115-62-5

ISX-9

Synonyms: Isoxazole 9

ISX-9 is a small molecule inducer of adult neural stem cell differentiation.

Cat. No.

A16091

CAS No.

165682-93-9

O4I2

O4I2 is a potent inducers of Oct3/4. O4I2 showed high activity in enforcing Oct3/4 expression. O4I2 is a new class of small molecules suitable for iPSC generation.

Cat. No.

A17129

CAS No.

667463-62-9

BIO

Synonyms: GSK3 Inhibitor IX; MLS 2052

BIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3α/β with IC50 value of 5 nM.

Cat. No.

A18175

CAS No.

13492-01-8

Tranylcypromine hemisulfate

Synonyms: SKF 385 hemisulfate

Tranylcypromine hemisulfate is an irreversible, nonselective inhibitor of monoamine oxidase (MAO) and also acts as a lysine-specific demethylase 1 (LSD1) inhibitor. This compound demonstrates notable antidepressant effects and is utilized in the treatment of depression. Additionally, tranylcypromine hemisulfate has been shown to suppress lesion growth and alleviate generalized hyperalgesia in mouse models of induced endometriosis, making it a valuable tool for research in both psychiatric and pain-related studies.