Hesperadin

Catalog No.: A10448

Aurora B Kinase inhibitor

Hesperadin

Hesperadin Chemical Structure

CAS NO. 422513-13-1

Hesperadin is a human Aurora B inhibitor with an IC50 of 40 nM for the prevention of the phosphorylation of substrate. It markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1 and PHK while it does not inhibit MKK1 activity in vivo.

Availability: In stock

Package Price Qty
5 mg
$80.00
10 mg
$150.00
50 mg
$540.00
100 mg
$920.00
10mM * 1mL in DMSO
$152.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Wenbin Ji, .et al. OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases, PLoS One, 2016, 11(4): e0153518 PMID: 27082996

Biological Activity

Hesperadin is a human Aurora B inhibitor with an IC50 of 40 nM for the prevention of the phosphorylation of substrate. It markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1 and PHK while it does not inhibit MKK1 activity in vivo.
Targets
TbAUK1 (Cell-free assay) Aurora B (human) (Cell-free assay)
40 nM250 nM
In vitro (25°C) DMSO 103 mg/mL (199.36 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.35 mL 96.77 mL 193.54 mL
0.5 mM 3.87 mL 19.35 mL 38.71 mL
1 mM 1.94 mL 9.68 mL 19.35 mL
5 mM 0.39 mL 1.94 mL 3.87 mL

*The above data is based on the productmolecular weight 516.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10448
Actions Inhibitor
M. Wt 516.7
Formula C29H32N4O3S
Solubility DMSO>103mg/mL Water<1mg/mL Ethanol>3mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 422513-13-1
SMILES CCS(=O)(=O)NC1=CC\2=C(C=C1)NC(=O)/C2=C(/C3=CC=CC=C3)\NC4=CC=C(C=C4)CN5CCCCC5

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