PHA-680632

Catalog No.: A10714

Aurora inhibitor

PHA-680632

PHA-680632 Chemical Structure

CAS NO. 398493-79-3

PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $90.00

Special Price $81.00

10 mg

Regular Price: $160.00

Special Price $144.00

50 mg

Regular Price: $450.00

Special Price $405.00

100 mg

Regular Price: $750.00

Special Price $675.00

10mM * 1mL in DMSO

Regular Price: $149.00

Special Price $134.10

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.
Targets
Target Value
AuroraAIC50: 27nM
AuroraCIC50: 120nM
AuroraBIC50: 135nM
FGFR1IC50: 390nM
PLK1IC50: 780nM
FLT3IC50: 820nM
VEGFR3IC50: 1000nM
VEGFR2IC50: 1920nM
LCKIC50: 1950nM
STLK2IC50: 5500nM
In vitro (25°C) DMSO 100 mg/mL (199.35 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 10% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.94 mL 99.68 mL 199.36 mL
0.5 mM 3.99 mL 19.94 mL 39.87 mL
1 mM 1.99 mL 9.97 mL 19.94 mL
5 mM 0.4 mL 1.99 mL 3.99 mL

*The above data is based on the productmolecular weight 501.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10714
Actions Inhibitor
M. Wt 501.6
Formula C28H35N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 398493-79-3
Synonyms PHA680632
SMILES CCC1=C(C(=CC=C1)CC)NC(=O)N2CC3=C(C2)NN=C3NC(=O)C4=CC=C(C=C4)N5CCN(CC5)C

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy PHA-680632 | PHA-680632 Supplier | purchase PHA-680632 | PHA-680632 cost | PHA-680632 manufacturer | order PHA-680632 | PHA-680632 distributor | buy 398493-79-3| 398493-79-3 Supplier | purchase 398493-79-3 | 398493-79-3 cost | 398493-79-3 manufacturer | order 398493-79-3 | 398493-79-3 distributor
Rewards