Biological Activity
PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.
Targets
Target | Value |
---|---|
AuroraA | IC50: 27nM |
AuroraC | IC50: 120nM |
AuroraB | IC50: 135nM |
FGFR1 | IC50: 390nM |
PLK1 | IC50: 780nM |
FLT3 | IC50: 820nM |
VEGFR3 | IC50: 1000nM |
VEGFR2 | IC50: 1920nM |
LCK | IC50: 1950nM |
STLK2 | IC50: 5500nM |
In vitro (25°C) | DMSO | 91 mg/mL (181.41 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 5% DMSO+50% PEG 300+5% Tween 80+ddH2O | 14 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 19.94 mL | 99.68 mL | 199.36 mL |
0.5 mM | 3.99 mL | 19.94 mL | 39.87 mL |
1 mM | 1.99 mL | 9.97 mL | 19.94 mL |
5 mM | 0.4 mL | 1.99 mL | 3.99 mL |
*The above data is based on the productmolecular weight 501.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10714 |
---|---|
Actions | Inhibitor |
CAS No. | 398493-79-3 |
Formula | C28H35N7O2 |
M. Wt | 501.6 |
Purity | >98% |
Synonyms | PHA680632 |
SMILES | CCC1=C(C(=CC=C1)CC)NC(=O)N2CC3=C(C2)NN=C3NC(=O)C4=CC=C(C=C4)N5CCN(CC5)C |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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