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|Storage||at -20°C 3 years Powder|
|PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.|
|Solubility (25°C) *||In vitro||DMSO||100 mg/mL (199.35 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||10% Tween 80||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||19.94 mL||99.68 mL||199.36mL|
|0.5 mM||3.99 mL||19.94 mL||39.87 mL|
|1 mM||1.99 mL||9.97 mL||19.94 mL|
|5 mM||0.4 mL||1.99 mL||3.99 mL|
*The above data is based on the productmolecular weight 501.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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