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Aurora Kinase A/B inhibitor

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Catalog No. A11067

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
TAK-901 5mg A11067-5

Regular Price: €85.50

Special Price: €76.95

TAK-901 10mg A11067-10

Regular Price: €152.00

Special Price: €136.80

TAK-901 50mg A11067-50

Regular Price: €427.50

Special Price: €384.75

TAK-901 100mg A11067-100

Regular Price: €712.50

Special Price: €641.25

TAK-901 10mM * 1mL in DMSO A11067-10mM-D

Regular Price: €104.50

Special Price: €94.05

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

TAK-901 is a novel inhibitor of Aurora A/B with IC50 of 21 nM/15 nM. It is not a potent inhibitor of cellular JAK2, c-Src or Abl. Phase 1.


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Chemical Information

Catalog Num A11067
Actions Inhibitor
M. Wt 504.6
Formula C28H32N4O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 934541-31-8
Synonyms TAK901

Biological Activity

TAK-901 is a novel inhibitor of Aurora A/B with IC50 of 21 nM/15 nM. It is not a potent inhibitor of cellular JAK2, c-Src or Abl. Phase 1.
Target Value
JAK3IC50: 1.2nM
c-SrcIC50: 1.3nM
CLK2IC50: <2.0nM
FGRIC50: <2.0nM
YES1IC50: <2.0nM
LRRK2IC50: 3.0nM
FLT3IC50: 5.0nM
FynIC50: 5.3nM
ARGIC50: 5.6nM
AxlIC50: 5.8nM
HckIC50: 5.8nM
SNF1LK2IC50: 6.0nM
AblIC50: 6.4nM
RETIC50: 6.5nM
TrkAIC50: 6.7nM
LCKIC50: 6.8nM
PTK5IC50: 7.1nM
FmsIC50: 7.2nM
FGFR2IC50: 7.3nM
EphB1IC50: 8.9nM
Abl(T315I)IC50: 9.0nM
EphA1IC50: 9.1nM
ARK5IC50: 9.1nM
ITKIC50: 12nM
ALK2IC50: 13nM
CDK7IC50: 14nM
BLKIC50: 14nM
AuroraB-INCENPIC50: 15nM
JAK2IC50: 17nM
EphB2IC50: 18nM
AuroraA-TPX2IC50: 21nM
STK16IC50: 24nM
EphA2IC50: 24nM
BRKIC50: 25nM
EphB4IC50: 27nM
TNK2IC50: 27nM
FGFR1IC50: 28nM
EphA4IC50: 31nM
STK33IC50: 35nM
CLK1IC50: 45nM
AMPKIC50: 46nM
FESIC50: 48nM
SLKIC50: 49nM
Chk2IC50: 50nM
TYK2IC50: 54nM
BTKIC50: 55nM
FAK2IC50: 55nM
c-KitIC50: 58nM
VEGFR2IC50: 60nM
FGFR3IC50: 65nM
ALK5IC50: 78nM
MAP3K9IC50: 80nM
CLK3IC50: 88nM
JAK1IC50: 93nM


Solubility (25°C)* In vitro DMSO 101 mg/mL (200.14 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.82 mL 99.09 mL 198.18mL
0.5 mM 3.96 mL 19.82 mL 39.64 mL
1 mM 1.98 mL 9.91 mL 19.82 mL
5 mM 0.4 mL 1.98 mL 3.96 mL

*The above data is based on the productmolecular weight 504.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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