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PHA-793887

PHA-793887

Name: PHA-793887
Brand: Adooq Bioscience
SKU: A10716
Rating: 100 (1 reviews)

Catalog No.: A10716

CDK Inhibitor

Product Citations (1)

PHA-793887 Chemical Structure

CAS NO. 718630-59-2

PHA-793887, a novel potent inhibitor of Cdk, target on kinds of cyclin-dependent kinase under low concentrations and poses high activity against several cancer cell lines.

Availability: In stock

Package	Price	Qty
5 mg	$90.00
10 mg	$150.00
50 mg	$450.00
100 mg	$750.00
10mM * 1mL in DMSO	$110.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq PHA-793887

Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168

Biological Activity

PHA-793887, a novel potent inhibitor of Cdk, target on kinds of cyclin-dependent kinase under low concentrations and poses high activity against several cancer cell lines.

Targets

Target	Value
CDK5/p25	IC50: 5nM
CDK2/CyclinA	IC50: 8nM
CDK2/CyclinE	IC50: 8nM
CDK7/CyclinH	IC50: 10nM
CDK1/CyclinB	IC50: 60nM
CDK4/CyclinD1	IC50: 62nM
GSK-3β	IC50: 79nM
CDK9/CyclinT1	IC50: 138nM

Solubility *

In vitro (25°C)	DMSO	61 mg/mL (168.75 mM)
	Water	Insoluble
	Ethanol	61 mg/mL (168.75 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.66 mL	138.31 mL	276.63 mL
0.5 mM	5.53 mL	27.66 mL	55.33 mL
1 mM	2.77 mL	13.83 mL	27.66 mL
5 mM	0.55 mL	2.77 mL	5.53 mL

*The above data is based on the productmolecular weight 361.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10716
Actions	Inhibitor
CAS No.	718630-59-2
Formula	C19H31N5O2
M. Wt	361.5
Purity	>98%
Synonyms	PHA793887
SMILES	CC(C)CC(=O)NC1=NNC2=C1CN(C2(C)C)C(=O)C3CCN(CC3)C
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.