CCT129202

Catalog No.: A10184

Aurora Inhibitor

CCT129202

CCT129202 Chemical Structure

CAS NO. 942947-93-5

CCT129202 is a representative of a structurally novel series of imidazopyridine small-molecule inhibitors of Aurora kinase activity. It shows high selectivity for the Aurora kinases over a panel of other kinases tested and inhibits proliferation in multiple cultured human tumor cell lines.

Availability: In stock

Package Price Qty
5 mg
$95.00
10 mg
$180.00
50 mg
$520.00
100 mg
$938.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

CCT129202 is a representative of a structurally novel series of imidazopyridine small-molecule inhibitors of Aurora kinase activity. It shows high selectivity for the Aurora kinases over a panel of other kinases tested and inhibits proliferation in multiple cultured human tumor cell lines.

Targets
Aurora A Aurora B Aurora C
42 nM198 nM227 nM
In vitro (25°C) DMSO 3 mg/mL (6.03 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.12 mL 100.6 mL 201.21 mL
0.5 mM 4.02 mL 20.12 mL 40.24 mL
1 mM 2.01 mL 10.06 mL 20.12 mL
5 mM 0.4 mL 2.01 mL 4.02 mL

*The above data is based on the productmolecular weight 497.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A10184
Actions Inhibitor
M. Wt 497.0
Formula C23H25ClN8OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 942947-93-5
Synonyms CCT-129202
SMILES CN(C)C1=CC=C(C=C1)C2=NC3=NC=C(C(=C3N2)N4CCN(CC4)CC(=O)NC5=NC=CS5)Cl

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