Ras | Adooq Bioscience

Cat. No.: A16097

CAS No.: 1469338-01-9

6H05

Synonyms: K-Ras inhibitor

6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C).

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All 4 sizes

Cat. No.: A16175

CAS No.: 2002381-31-7

APS-2-79 HCl

Synonyms: KSR/Ras Inhibitor

APS-2-79 HCl, small molecule that stabilizes the KSR (Kinase suppressor of Ras) inactive state and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2).

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1 mg

$30.00

2 mg

$45.00

All 9 sizes

Cat. No.: A16482

CAS No.: 2326521-71-3

Adagrasib (MRTX849)

Synonyms: MRTX 849

Adagrasib (MRTX849) is a potent, orally-available, and mutation-selective covalent inhibitor of KRAS G12C with potential antineoplastic activity.

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5 mg

$50.00

10 mg

$85.00

All 7 sizes

Cat. No.: A16621

CAS No.: 71203-35-5

ML141 (CID-2950007) is a potent, allosteric, selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC50s of 2.1 and 2.6 μM, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines.

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1 mg

$25.00

2 mg

$40.00

All 7 sizes

Cat. No.: A16681

CAS No.: 361185-42-4

RBC8

RBC8 is a novel small molecule inhibitor of Ral GTPase; has IC50 of 3.5 μM in H2122 cell and 3.4 μM in H358 cell.

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1 mg

$35.00

5 mg

$85.00

All 8 sizes

Cat. No.: A16808

CAS No.: 2097938-73-1

MBQ-167

MBQ-167 is a potent and dual inhibitor of Rac and Cdc42 with IC50s of 103 nM and 78 nM respectively, in metastatic breast cancer cells.

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1 mg

$25.00

2 mg

$35.00

All 8 sizes

Cat. No.: A16809

CAS No.: 1698055-85-4

ARS-1620

ARS-1620 is a potent, orally bioavailable covalent inhibitor of KRAS-G12C) and could achieve rapid and sustained in vivo target occupancy to induce tumor regression.

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1 mg

$75.00

2 mg

$110.00

All 8 sizes

Cat. No.: A16874

CAS No.: 2226507-04-4

BDP9066

BDP9066 is a potent and selective MRCK inhibitor, reducing substrate phosphorylation.

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1 mg

$45.00

2 mg

$80.00

All 9 sizes

Cat. No.: A16928

CAS No.: 1443437-74-8

CCG-203971

CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50 = 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.

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5 mg

$30.00

10 mg

$40.00

All 7 sizes

Cat. No.: A16965

CAS No.: 1430208-73-3

1A-116

1A-116 is a specific Rac1 inhibitor, can prevent EGF-induced Rac1 activation and block Rac1-P-Rex1 interaction. 1A-116 can induce apoptosis and inhibit cell proliferation, migration and cycle progression in a concentration-dependent manner. 1A-116 also demonstrates a high antimetastatic activity in vivo.

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1 mg

$40.00

5 mg

$105.00

All 8 sizes

Cat. No.: A16966

CAS No.: 1817698-21-7

BDP5290

BDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.

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1 mg

$45.00

2 mg

$65.00

All 8 sizes

Cat. No.: A17060

CAS No.: 1698024-73-5

ARS-1323

ARS-1323 is a novel inhibitor of mutant K-ras G12C.

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1 mg

$30.00

5 mg

$70.00

All 7 sizes

Cat. No.: A17061

CAS No.: 1698055-86-5

ARS-1630

ARS-1630 is a novel inhibitor of mutant K-ras G12C.

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1 mg

$40.00

5 mg

$110.00

All 7 sizes

Cat. No.: A17183

CAS No.: 91531-30-5

Antineoplaston A10

Antineoplaston A 10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.

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2 mg

$30.00

5 mg

$60.00

All 8 sizes

Cat. No.: A17222

CAS No.: 1835283-94-7

Ras-IN-3144

Synonyms: 3144; pan-RAS inhibitor-3144

Ras-IN-3144 is a pan-RAS inhibitor which inhibits RAS signaling pathways in cancer cells and prevents the growth of RAS mutant mouse cancer xenografts.

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1 mg

$65.00

2 mg

$90.00

All 9 sizes

Cat. No.: A17223

CAS No.: 2206736-04-9

MRTX1257

MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM.

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1 mg

$50.00

2 mg

$75.00

All 8 sizes

Cat. No.: A18319

CAS No.: 2244904-70-7

BAY 293

BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 21 nM.

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1 mg

$40.00

5 mg

$105.00

All 7 sizes

Cat. No.: A18395

CAS No.: 2328073-61-4

ZT-12-037-01

ZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor. ZT-12-037-01 effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vitro and in vivo.

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1 mg

$25.00

5 mg

$60.00

All 7 sizes

Cat. No.: A18441

CAS No.: 2349393-04-8

KRAS G12C inhibitor 17

KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 82, has an IC50 of 5 nM.

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1 mg

$315.00

5 mg

$955.00

All 6 sizes

Cat. No.: A18444

CAS No.: 2349392-79-4

KRAS G12C inhibitor 16

KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 39, has an IC50 of 97 nM.

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1 mg

$315.00

2 mg

$600.00

All 6 sizes

Cat. No.: A18447

CAS No.: 2349393-21-9

KRAS G12C inhibitor 15

KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC50 of 5 nM.

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1 mg

$315.00

5 mg

$915.00

All 6 sizes

Cat. No.: A18473

CAS No.: 1614225-93-2

PHT-7.3

PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain, which inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling.

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5 mg

$215.00