Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Retinoid receptor ligands act on retinoic acid receptors (RARs) and retinoid X receptors (RXRs). Both are nuclear receptors with α, β and γ subtypes that bind DNA as RAR-RXR heterodimers and regulate gene transcription. A receptor for the morphogen retinoic acid was identified in 1987 as a member of the nuclear receptor family. In 1990 a second receptor responding to retinoic acid, later named RXRα, revealed a distinct retinoid pathway. Tretinoin, the all-trans form of retinoic acid, activates RARs, while tamibarotene and AM 580 favor RARα and CD 437 favors RARγ. Adapalene, tazarotene, acitretin and fenretinide are synthetic retinoids, whereas bexarotene is a ligand selective for RXRs.
Synonyms: UAB30
(all-E)-UAB30 is a selective agonist of the retinoid X receptor (RXR). It demonstrates significant anti-proliferative activity in MyLa, HuT 78, and HH cell lines, with IC50 values of 34.7 μM, 5.1 μM, and 22.4 μM, respectively. This compound is valuable for research focused on cancer biology and RXR signaling pathways, providing insights into cell growth regulation.
Out of stock
All 3 sizes
BMS-185354 is a selective retinoic acid receptor gamma (RARγ) activator, exhibiting an EC50 value of 28 nM. This compound plays a significant role in modulating gene expression involved in various biological processes. BMS-185354 is primarily utilized in cancer research to investigate the therapeutic potential of targeting RARγ pathways in oncogenesis and tumor progression.
Out of stock
All 3 sizes
AGN 191701 is a selective retinoic acid receptor (RAR) and retinoid X receptor (RXR) inhibitor. This compound has been shown to induce liver enlargement in rat models while preserving hepatocellular integrity, indicating a unique biological profile. AGN 191701 serves as a valuable tool for studying retinoid signaling pathways and their implications in hepatic processes.
Nurr1/RXR Agonist 1 is a dual agonist that specifically targets the Nurr1 receptor (EC50 = 2.6 µM) and retinoid X receptor (RXR) with affinity constants of 0.6 and 1.1 µM, respectively. This compound selectively activates the DR5 response element by destabilizing the Nurr1 homodimer while stabilizing the Nurr1:RXR heterodimer. Nurr1/RXR Agonist 1 promotes the expression of neuroprotective target genes while minimizing off-target effects in neuronal cells. This reagent is suitable for research in neurodegenerative diseases.
Out of stock
All 3 sizes
JP3000 is a potent agonist of retinoic acid receptors RARA, RARB, and RARG. This compound is designed to modulate gene expression involved in cellular differentiation, development, and homeostasis. Its applications in research include investigating the molecular mechanisms of retinoid signaling in various biological processes and disease states, making it a valuable tool for exploring therapeutic strategies in cancer and metabolic disorders.
Out of stock
All 3 sizes
AGN 190727 is a structural isomer of AGN 190121 and serves as an antagonist of the retinoic acid receptors (RAR) and retinoid X receptors (RXR). Unlike its counterpart AGN 190121, AGN 190727 does not activate RAR/RXR pathways. This compound is relevant for research exploring RAR/RXR signaling modulation and investigating the physiological effects of receptor antagonism, particularly in studies related to dyslipidemia and metabolic disorders.
(E)-XS-060 is a selective RXRα antagonist that disrupts the interaction between pRXRα and PLK1. This compound induces RXRα-dependent mitotic arrest, thereby inhibiting cell proliferation. Its notable antitumor activity has been demonstrated in various cancer models, including breast cancer, lung adenocarcinoma, and liver cancer, making it a valuable tool for cancer research and therapeutic development.
Out of stock
All 3 sizes
CU-6PMN is a fluorescent retinoid X receptor (RXR) agonist that selectively activates human RXRα with an EC50 value of 22 nM and a Ki value of 230 nM. This compound exhibits a maximum absorption wavelength of 396 nm and an emission wavelength of 453 nm when dissolved in 0.1 N NaOH aqueous solution. CU-6PMN is valuable for research applications involving RXR ligand screening and provides a useful tool for studying RXR-mediated biological processes.
BMS-185411 is a selective antagonist of the retinoic acid receptor alpha (RARα), exhibiting an IC50 value of 140 nM. This compound is instrumental in research focusing on the modulation of retinoic acid signaling pathways, particularly in the context of cellular differentiation, development, and cancer biology. Its ability to inhibit RARα activity makes it valuable for studies investigating the role of retinoic acid receptors in various biological processes.
Seletinoid G is a potent retinoic acid receptor (RAR) agonist. It demonstrates significant biological activity by promoting the repair of altered connective tissue in aged skin while inhibiting UV-induced collagen deficiency in younger skin. This compound is valuable for research applications focused on skin aging and photoaging, facilitating the exploration of therapeutic strategies for improving skin health and resilience.
Out of stock
All 3 sizes
SRI 6409-94 is an orally active analogue of Ro 13-6298, specifically designed to investigate the teratogenic effects of retinol's three-dimensional structure. This compound serves as a valuable molecular tool for researchers studying the relationship between retinol configuration and teratogenic activity. Its unique properties enable a deeper understanding of retinoid-mediated developmental processes.
Synonyms: CBS-211A
Namirotene is a retinoic acid analog that functions primarily by enhancing the cytotoxic effects of 1α,25-dihydroxyvitamin D3 in U937 cells. This compound also promotes differentiation within the U937 cell line, making it valuable for research into cellular processes and therapeutic applications in cancer treatment and differentiation studies. Its topical eye administration further broadens its potential therapeutic relevance.
