RORγ(t) Inverse Agonists & Antagonists

Cat. No.: A77586

CAS No.: 1675206-11-7

ARN-6039

ARN-6039 is an orally active inverse agonist of RORγ, a transcription factor involved in the regulation of various immune responses. This compound demonstrates potential in modulating immune activity and may be effective in the treatment of autoimmune demyelinating diseases. It serves as a valuable tool for research aimed at understanding the role of RORγ in immune-related disorders and developing therapeutic strategies targeting these conditions.

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Cat. No.: A77588

CAS No.: 2079892-79-6

RORγt Inverse agonist 8

RORγt Inverse Agonist 8 acts as a selective inverse agonist targeting the retinoic acid receptor-related orphan receptor gamma t (RORγt). With an IC50 of 19 nM for the human RORγt ligand-binding domain, this compound demonstrates significant potential in modulating RORγt activity. Its biological activity is relevant for research in autoimmune diseases and T helper 17 (Th17) cell differentiation, providing a valuable tool for investigators studying immune response pathways.

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Cat. No.: A77591

CAS No.: 1422053-03-9

TMP780

TMP780 is an inverse agonist of the nuclear receptor RORγt, demonstrating an IC50 value of 13 nM. This compound exhibits potential for modulating immune responses and inflammation, making it a valuable tool for research related to cutaneous inflammatory disorders. Its ability to inhibit RORγt activity positions TMP780 as a promising candidate for studies aimed at uncovering therapeutic strategies in inflammatory diseases.

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$370.00

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$670.00

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Cat. No.: A77594

CAS No.: 2741870-21-1

RORγt inverse agonist 28

RORγt inverse agonist 28 is a potent inverse agonist targeting the retinoic acid receptor-related orphan receptor gamma t (RORγt). It effectively regulates the differentiation of T helper 17 (Th17) cells and inhibits interleukin-17 (IL-17) production. This compound is valuable for research into inflammation and autoimmune diseases, providing insights into potential therapeutic approaches.

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Cat. No.: A77596

CAS No.: 1242610-59-8

RORγ inverse agonist 2

RORγ inverse agonist 2 is a potent inverse agonist targeting the retinoic acid receptor-related orphan receptor RORγ, exhibiting IC50 values of 0.4 μM and 0.9 μM for Gal4-RORγ and full-length RORγ, respectively. This compound is significant for research applications focused on autoimmune diseases, providing insights into RORγ's role in immune regulation and pathology.

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Cat. No.: A77597

CAS No.: 1599531-55-1

JNJ-54119936

JNJ-54119936 is an inverse agonist of the retinoic acid receptor-related orphan receptor gamma (RORγ) with a Kd of 5.3 nM. This compound exhibits significant modulation of RORγ activity, making it valuable for research into autoimmune diseases and inflammatory responses. Its specific targeting of RORγ allows for the exploration of downstream signaling pathways and therapeutic applications in related biological processes.

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Cat. No.: A77601

CAS No.: 2247604-77-7

RORγt inverse agonist 34

RORγt inverse agonist 34 is a selective inverse agonist of the retinoic acid receptor-related orphan receptor gamma t (RORγt), exhibiting an IC50 of 0.094 μM for the RORγt-LBD. This compound demonstrates significant biological activity in modulating RORγt signaling pathways, making it a valuable tool for research into psoriasis and related inflammatory conditions. Its use facilitates the exploration of therapeutic strategies targeting RORγt in the regulation of immune responses.

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Cat. No.: A77603

CAS No.: 2301159-96-4

RORγt inverse agonist 32

RORγt Inverse Agonist 32 is an orally active compound that targets the RORγt receptor as an inverse agonist. It plays a critical role in modulating inflammatory pathways and is valuable for research into immune responses and related diseases. This compound is particularly useful for studies focusing on the regulation of Th17 cell differentiation and the development of autoimmune conditions.

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Cat. No.: A77606

CAS No.: 1952239-59-6

CD12681

CD12681 is a selective inverse agonist of RORγ, exhibiting IC50 values of 19 nM and 10 nM against RORγ GAL4 and CD4-IL-17 cells, respectively. This compound effectively reduces IL-17-mediated inflammatory cell recruitment, making it a valuable tool for studying inflammatory pathways. CD12681 shows promise for research applications in conditions such as psoriasis, facilitating the exploration of novel therapeutic strategies.

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Cat. No.: A77607

CAS No.: 2309312-90-9

SR1555 hydrochloride

SR1555 hydrochloride is a selective inverse agonist of the retinoic acid receptor-related orphan nuclear receptor γ (RORγ), exhibiting an IC50 of 1 μM. This compound effectively inhibits the development and function of pro-inflammatory TH17 cells while promoting an increase in anti-inflammatory T regulatory (Treg) cells. SR1555 hydrochloride is primarily utilized in research targeting autoimmune diseases, providing insights into potential therapeutic strategies for immune modulation.

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Cat. No.: A77609

CAS No.: 1599530-54-7

RORγt inverse agonist 36

RORγt inverse agonist 36 is a selective inverse agonist targeting the retinoid-related orphan receptor gamma t (RORγt). This compound modulates RORγt activity, leading to inhibition of Th17 cell differentiation and cytokine production. It is primarily utilized in research focused on inflammation and immunology, offering valuable insights into therapeutic approaches for autoimmune diseases.

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Cat. No.: A77610

CAS No.: 1445901-41-6

RORγt inverse agonist 30

RORγt Inverse Agonist 30 is a selective inverse agonist of the RORγt nuclear receptor, exhibiting an IC50 of 46 nM. This compound effectively modulates RORγt activity, making it a valuable tool in the study of autoimmune disorders. Its ability to inhibit RORγt function positions it as a promising candidate for research into therapeutic strategies for conditions such as multiple sclerosis and other inflammatory diseases.

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