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$0.00 HIV Integrase
HIV Integrase is an enzyme found in HIV (and other retroviruses). HIV uses integrase to insert (integrate) its viral DNA into the DNA of the host CD4 cell. Integration is a crucial step in the HIV life cycle and is blocked by a class of antiretroviral (ARV) HIV drugs called integrase strand transfer inhibitors (INSTIs).
| Catalog No. | Inhibitor Name | Integrase |
|---|---|---|
| A10775 | Raltegravir (MK-0518) | * |
| A10347 | Elvitegravir (GS-9137, JTK-303) | **** |
| A11068 | Dolutegravir (GSK1349572) | *** |
| A10156 | BMS-707035 | ** |
| A11135 | MK-2048 | *** |
| A16014 | Cabotegravir (GSK744, GSK1265744) |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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HIV-1 integrase inhibitor
Catalog No. A11446 -
HIV-1 integrase inhibitor 2
Catalog No. A11447 HIV-1 integrase inhibitorHIV-1 integrase inhibitor 2, in the treatment of human immunodeficiency virus (HIV) infection. Learn More -
Raltegravir (MK-0518)
Catalog No. A10775 HIV-1 integrase inhibitorRaltegravir (MK-0518) targets integrase, an HIV enzyme that integrates the viral genetic material into human chromosomes, a critical step in the pathogenesis of HIV. Learn More -
S/GSK1349572 (Dolutegravir)
Catalog No. A11068 HIV integrase inhibitorS/GSK1349572 is a potent next generation HIV integrase inhibitor and demonstrates a superior resistance profile substantiated with 60 integrase mutant molecular clones. Learn More -
MK-2048
Catalog No. A11135 HIV integrase inhibitorMK-2048 is a second generation integrase inhibitor, intended to be used against HIV infection. Learn More -
BMS-707035
Catalog No. A10156 HIV-1 integrase inhibitorBMS-707035 is an HIV-1 integrase (IN) inhibitor. HIV-1 integrase (IN) represents a therapeutically advantageous viral target to treat HIV/AIDS in the clinic.
Learn More -
Elvitegravir (GS-9137)
Catalog No. A10347 HIV integrase inhibitorElvitegravir (GS-9137) is a potent inhibitor of the strand-transfer step of integration mediated by human immunodeficiency virus type 1 (HIV-1) integrase. Learn More -
GSK1265744 (GSK744) Sodium salt
Catalog No. A13984 HIV Integrase InhibitorGSK1265744 (GSK744) is a potential inhibitor of HIV integrase with IC50 value of 3 nM Learn More -
GSK744 (S/GSK1265744)
Catalog No. A16014 HIV integrase inhibitorGSK744 is a potent HIV integrase inhibitor as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection. Learn More -
BI 224436
Catalog No. A16018 HIV integrase inhibitorBI 224436 is a novel HIV-1 non-catalytic-site integrase inhibitor; has antiviral EC50s of <15 nM against different HIV-1 laboratory strains and cellular cytotoxicity of >90 μM. Learn More -
Dolutegravir Sodium
Catalog No. A16162 HIV integrase inhibitorDolutegravir sodium is a HIV integrase inhibitor(IC50= 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. Learn More -
Bictegravir
Catalog No. A17011 HIV-1 integrase InhibitorBictegravir, also known as GS-9883, is a potent, unboosted, once-Daily HIV-1 Integrase Strand Transfer Inhibitor (INSTI) (IC50 - 1.6 nM) with improved pharmacokinetics and in vitro resistance profile. Learn More -
Raltegravir potassium
Catalog No. A21403 integrase (IN) inhibitorRaltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection. Learn More
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