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Catalog No.
Product Name
Application
Product Information
Citations
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β-lactamase Inhibitor
Izumenolide is a potent β-lactamase inhibitor derived from the strain Micromonospora chalcea subsp. izumensis. It exhibits significant inhibitory activity against certain β-lactamases, with an IC50 value of 0.01 μg/mL specifically for TEM-2 β-lactamase. This compound is valuable for research applications focused on antibiotic resistance and the development of new therapeutic strategies targeting bacterial infections. -
Serine β-Lactamase Inhibitor
Pilabactam is a potent covalent inhibitor of serine β-lactamases, exhibiting IC50 values between 1 nM and 175 nM across various serine β-lactamase types. This compound significantly enhances the efficacy of β-lactam antibiotics against challenging pathogens such as Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam is valuable in research focused on bacterial infections and antibiotic resistance mechanisms. -
β-lactamase Inhibitor
β-Lactamase-IN-5 is a potent β-lactamase inhibitor that serves to enhance the efficacy of β-lactam antibiotics against resistant bacterial strains. Its primary mechanism involves the inhibition of β-lactamase enzymes, which are responsible for antibiotic resistance. This compound is valuable for research applications aimed at understanding and combating bacterial infections, particularly those caused by multidrug-resistant pathogens. -
β-lactamase Inhibitor
CB-618 is a β-lactamase inhibitor that reversibly covalently interacts with Ambler class A, C, and select class D serine β-lactamases. While it exhibits limited antibacterial activity on its own, CB-618 notably enhances the effectiveness of Meropenem against enzyme-producing Enterobacteriaceae. This compound is a valuable tool for research focused on combating drug-resistant bacterial strains. -
β-Lactamase Inhibitor
LN-1-255 sodium is a β-lactamase inhibitor designed to effectively combat resistance in bacteria. It exhibits a broad-spectrum inhibitory effect on type D carbapenemases, demonstrating an IC50 of 3 nM against OXA-48, while also showing strong activity against OXA-23 and OXA-24/40. The compound enhances the efficacy of carbapenem antibiotics through a synergistic mechanism. LN-1-255 sodium is a valuable tool for researching the challenges posed by carbapenem-hydrolyzing class D β-lactamases (CHDLs) in bacterial resistance. -
Beta-lactamase Inhibitor
Relebactam sodium is a potent and selective β-lactamase inhibitor that functions to inhibit the enzymatic breakdown of β-lactam antibiotics. By binding to a diverse range of β-lactamases, Relebactam sodium enhances the effectiveness of these antibiotics and delays the emergence of bacterial resistance. This compound is particularly valuable in research focusing on combating complex bacterial infections and improving antibiotic therapeutic options. -
Beta-lactamase Inhibitor
Ent-Avibactam sodium is a β-lactamase inhibitor designed to combat a wide range of bacterial infections. It effectively inhibits Ambler A and C type β-lactamases produced by Enterobacteriaceae, enhancing the efficacy of β-lactam antibiotics like Cefazidime. With an IC50 value significantly lower than other commonly used β-lactamase inhibitors, ent-Avibactam sodium demonstrates superior potency against TEM-1 and P99 enzymes, making it a valuable tool for bacterial resistance research and antibiotic development. -
Metallo-β-lactamase Inhibitor
Metallo-β-lactamase-IN-8 is a potent reversible and competitive inhibitor of metallo-β-lactamases (MβLs), exhibiting IC50 values of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM against L1, ImiS, IMP-1, and VIM-2 respectively. This compound demonstrates significant antibacterial activity, making it a valuable tool for studying β-lactam resistance mechanisms in bacterial pathogens. Its ability to inhibit a broad spectrum of MβLs highlights its potential for research applications in antimicrobial resistance and drug development. -
β-lactamase/PBP Inhibitor
FPI-1465 is a dual inhibitor targeting serine β-lactamases and penicillin-binding proteins (PBPs). This compound effectively inhibits PBP2 with an IC50 value of 1.0 µg/mL, demonstrating significant activity against β-lactamase enzymes CTX-M-15 and OXA-48, with Kd values of 0.011 µM and 5.3 µM, respectively. FPI-1465 is suitable for research applications focused on antibiotic resistance and the modulation of β-lactam antibiotic efficacy. -
Beta-lactamase Inhibitor
Xeruborbactam is a potent boronic acid beta-lactamase inhibitor that targets both serine and metallo beta-lactamases with high efficacy. Demonstrating activity in the nanomolar range, it serves as an ultra-broad-spectrum agent in combating antibiotic resistance. Xeruborbactam is valuable for research applications focused on understanding beta-lactamase activity and developing novel antimicrobial strategies. -
beta-lactamase inhibitor
Durlobactam, also known as ETX2514, is a beta-lactamase inhibitor drug candidate. -
non-β-lactam β-lactamase inhibitor
Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively. -
β-lactamase inhibitor
Zidebactam sodium salt (WCK-5107 sodium salt) is a potent β-lactamase inhibitor. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL. -
β-lactamase inhibitor
Vaborbactam is a cyclic boronic acid pharmacophore β-lactamase inhibitor. -
diazabicyclooctane inhibitor
Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases [ESBLs] and KPC) and class C (AmpC) enzymes. -
β-lactamase inhibitor
Taniborbactam is a potent inhibitor of β-lactamase, with IC50s of <100 nM for SHV-5, KPC-2, VIM-2, and AmpC β-lactamase, and 0.1 to 1 μM for OXA-1 β-lactamase, used in the research of bacterial infections. -
β-lactamase inhibitor
Zidebactam (WCK-5107) is a potent β-lactamase inhibitor. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL. -
non-β-lactam-β-lactamase inhibitor
Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and class C β-lactamases. -
β-lactamase Inhibitor
RDR 02308 is a β-lactamase inhibitor that targets the TLR4-MyD88 signaling pathway. This compound effectively inhibits the activity of full-length β-lactamase, providing a valuable tool for studies related to antibiotic resistance. Its mechanism of action makes it suitable for research applications focused on bacterial infections and the development of novel therapeutic strategies.
