AChE

Acetylcholinesterase (AChE) inhibitors block the enzyme that breaks down acetylcholine at cholinergic synapses. By ending acetylcholine signaling within milliseconds, AChE controls transmission in the brain and at the neuromuscular junction. The 1991 crystal structure of AChE from Torpedo californica showed the active site at the base of a deep, narrow gorge. AChE also has non-catalytic roles, which broaden its interest beyond synaptic transmission. Inhibitors here include donepezil hydrochloride and galanthamine hydrobromide, which are reversible inhibitors. The carbamates rivastigmine tartrate and neostigmine bromide, used in studies of cholinergic signaling and neurodegeneration, are also listed.

Items 601-625 of 663

  • (-)-Mornaphthoate B
    Cat. No.
    A95725

    (-)-Mornaphthoate B

    (-)-Mornaphthoate B is a methyl 2-naphthoate derivative isolated from the roots of Morinda officinalis var. officinalis. This compound does not exhibit inhibitory activity against acetylcholinesterase or butyrylcholinesterase. (-)-Mornaphthoate B serves as a valuable tool in cancer research, particularly in studies focused on non-small cell lung cancer and triple-negative breast cancer, contributing to understanding therapeutic strategies and mechanisms of action in these malignancies.

    Out of stock

    All 3 sizes
  • Oximino oxamyl
    Cat. No.
    A95826

    Oximino oxamyl

    Synonyms: Oxamyl oxime

    Oximino oxamyl is a drug derivative known for its inhibitory action on acetylcholinesterase. This compound exhibits significant biological activity, making it useful in pharmacological studies focused on neurodegenerative diseases and pesticide resistance research. Its application extends to evaluating enzyme inhibition mechanisms and developing innovative therapeutic strategies.

    10 mg
    $190.00
    25 mg
    $400.00
    All 4 sizes
  • (+)-Mornaphthoate B
    Cat. No.
    A96284

    (+)-Mornaphthoate B (d-Mornaphthoate B)

    Synonyms: d-Mornaphthoate B

    (+)-Mornaphthoate B is a methyl 2-naphthoate derivative isolated from the roots of Morinda officinalis var. officinalis. This compound has been shown to lack activity against acetylcholinesterase and butyrylcholinesterase. Its unique chemical structure and biological properties make (+)-Mornaphthoate B a potential candidate for research applications focused on non-small cell lung cancer and triple-negative breast cancer.

    Out of stock

    All 3 sizes
  • (-)-Mornaphthoate D
    Cat. No.
    A96579

    (-)-Mornaphthoate D

    (-)-Mornaphthoate D is a methyl 2-naphthoate derivative that targets various biological pathways. Isolated from the roots of Morinda officinalis var. officinalis, this compound demonstrates no inhibitory activity against acetylcholinesterase or butyrylcholinesterase. Its unique properties make it pertinent for research in non-small cell lung cancer and triple-negative breast cancer, contributing to the exploration of potential therapeutic strategies in oncology.

    Out of stock

    All 3 sizes
  • (+)-Mornaphthoate C
    Cat. No.
    A96594

    (+)-Mornaphthoate C

    (+)-Mornaphthoate C is a methyl 2-naphthoate derivative primarily investigated for its potential therapeutic applications. Derived from the roots of Morinda officinalis var. officinalis, this compound has demonstrated negligible activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) at a concentration of 50 μM. Additionally, (+)-Mornaphthoate C exhibits minimal cytotoxicity towards various cancer cell lines, making it a compound of interest in drug development research.

    Out of stock

    All 3 sizes
  • Pirimicarb-desmethyl
    Cat. No.
    A97141

    Pirimicarb-desmethyl

    Pirimicarb-desmethyl is a key metabolite of the carbamate insecticide pirimicarb, functioning primarily through the inhibition of acetylcholinesterase activity. This compound offers valuable insights into the metabolic pathways of pirimicarb and can be used to study its environmental persistence and toxicological effects. Its application is important in both agricultural research and the assessment of pesticide safety.

    Out of stock

    All 3 sizes
  • Donepezil impurity 10
    Cat. No.
    A97161

    Donepezil impurity 10

    Donepezil impurity 10 is a known impurity associated with the compound Donepezil, a reversible inhibitor of the enzyme acetylcholinesterase. This reagent is significant for analytical studies aimed at monitoring the purity of Donepezil in pharmaceutical formulations. It serves as a reference standard in quality control processes and method development, ensuring compliance with regulatory guidelines in drug manufacturing and research applications.

    Out of stock

    All 3 sizes
  • Rivastigmine impurity 12
    Cat. No.
    A98140

    Rivastigmine impurity 12

    Synonyms: m-Methoxyacetophenone

    Rivastigmine impurity 12 (m-Methoxyacetophenone) is a known impurity associated with Rivastigmine, an acetylcholinesterase inhibitor used in the treatment of Alzheimer's disease. This compound serves as a valuable reference material for analytical chemistry applications, particularly in the development and validation of analytical methods for drug quality control. Its characterization contributes to ensuring the safety and efficacy of pharmaceutical formulations containing Rivastigmine.

    500 mg
    $20.00
    1 g
    $25.00
    All 2 sizes
  • Donepezil impurity 15
    Cat. No.
    A98595

    Donepezil impurity 15

    Donepezil impurity 15 is a chemical impurity associated with Donepezil, a reversible inhibitor of acetylcholinesterase. This impurity can serve as a reference standard in analytical and quality control laboratories for the characterization of Donepezil formulations. Research applications include stability testing, impurity profile assessments, and compliance with regulatory requirements in drug development.

    1 g
    $20.00
    5 g
    $35.00
    All 6 sizes
  • 5,6-Dimethoxyindan-1-one
    Cat. No.
    A98630

    5,6-Dimethoxyindan-1-one

    Synonyms: 5,6-Dimethoxyindanone

    5,6-Dimethoxyindan-1-one is a versatile drug intermediate employed in the synthesis of diverse active pharmaceutical ingredients. It has applications in the development of antiviral compounds and acetylcholinesterase butyrylcholinesterase inhibitors. This reagent serves as a critical building block in medicinal chemistry, facilitating the exploration of new therapeutic agents.

    1 mg
    $20.00
    25 g
    $25.00
    All 5 sizes
  • 4-Hydroxy-3,3-dimethylcyclohexanone
    Cat. No.
    A98735

    4-Hydroxy-3,3-dimethylcyclohexanone

    4-Hydroxy-3,3-dimethylcyclohexanone serves as a crucial intermediate in the synthesis of human acetylcholinesterase (hAChE) inhibitors. Its role in the development of hAChE inhibitors makes it significant for research in neuropharmacology and disease models related to cholinergic dysfunction. This compound's unique structural properties facilitate the exploration of therapeutic agents targeting cognitive disorders.

    5 mg
    $90.00
    10 mg
    $145.00
    All 5 sizes
  • Donepezil impurity 6
    Cat. No.
    A98944

    Donepezil impurity 6

    Donepezil impurity 6 is a known impurity associated with the cholinesterase inhibitor Donepezil. Its presence is significant for quality control and regulatory compliance in pharmaceutical formulations. This compound can be utilized in research to study the by-products and degradants of Donepezil, aiding in the development of more refined synthetic pathways and enhancing the understanding of drug stability and efficacy.

    Out of stock

    All 3 sizes
  • Rivastigmine impurity 2
    Cat. No.
    A99179

    Rivastigmine impurity 2

    Synonyms: Diethyl rivastigmine

    Rivastigmine impurity 2 is a known impurity associated with Rivastigmine, a reversible inhibitor of acetylcholinesterase. This compound can be utilized for analytical research and quality control studies in the pharmaceutical industry. Its characterization is essential for the assessment of drug purity and stability in formulations containing Rivastigmine.

    Out of stock

    All 3 sizes
  • Rivastigmine impurity 8
    Cat. No.
    A99233

    Rivastigmine impurity 8

    Rivastigmine impurity 8 is a chemical impurity associated with the cholinesterase inhibitor rivastigmine. This impurity serves as a reference standard for quality control and analytical applications in pharmaceutical research. It facilitates the identification and quantification of impurities in drug formulations, contributing to the assessment of drug purity and safety in clinical and preclinical studies.

    Out of stock

    All 3 sizes
  • Donepezil impurity 21
    Cat. No.
    A99323

    Donepezil impurity 21

    Donepezil impurity 21 is a known impurity of the cognitive-enhancing agent Donepezil, which primarily targets acetylcholinesterase to enhance cholinergic neurotransmission. This compound is essential for the analysis of Donepezil formulations, particularly in the context of pharmaceutical quality control and regulatory compliance. Its characterization aids in understanding the stability and purity of Donepezil, supporting ongoing research in neurodegenerative disease therapies.

    Out of stock

    All 3 sizes
  • Rivastigmine impurity 7
    Cat. No.
    A99343

    Rivastigmine impurity 7

    Rivastigmine impurity 7 is a recognized impurity derived from Rivastigmine, a reversible inhibitor of the enzyme acetylcholinesterase. This compound is primarily utilized in pharmaceutical research to study the purity and stability of Rivastigmine formulations. Its presence is critical in ensuring the quality and efficacy of cholinesterase inhibitors for therapeutic applications, particularly in the treatment of Alzheimer's disease.

    Out of stock

    All 3 sizes
  • Donepezil impurity 12
    Cat. No.
    A99526

    Donepezil impurity 12

    Donepezil impurity 12 is a known impurity of the acetylcholinesterase inhibitor Donepezil. This compound is utilized primarily in pharmacological research for analytical purposes, such as assessing the quality and purity of Donepezil formulations. Its characterization aids in understanding the stability and safety profiles of Donepezil-based therapies.

    Out of stock

    All 3 sizes
  • Rivastigmine impurity 10
    Cat. No.
    A99911

    Rivastigmine impurity 10

    Rivastigmine impurity 10 is a chemical impurity associated with the acetylcholinesterase inhibitor, Rivastigmine. This compound is primarily used for quality control and analytical purposes in pharmaceutical research. It is important for assessing the purity of Rivastigmine in formulations and ensuring compliance with regulatory standards.

    100 mg
    $20.00
    250 mg
    $40.00
    All 6 sizes
  • Donepezil impurity 16
    Cat. No.
    B10051

    Donepezil impurity 16

    Donepezil impurity 16 is a known impurity of the cholinesterase inhibitor Donepezil, primarily targeting acetylcholinesterase. This compound is utilized in research to ensure the quality and consistency of Donepezil formulations. Its analysis is critical for assessing drug safety and efficacy in pharmaceutical development.

    Out of stock

    All 3 sizes
  • Rivastigmine impurity 3
    Cat. No.
    B10084

    Rivastigmine impurity 3

    Synonyms: Rivastigmine impurity B

    Rivastigmine impurity 3 is a known impurity of the acetylcholinesterase inhibitor, Rivastigmine. This compound is utilized in quality control and analytical chemistry to assess the purity of Rivastigmine formulations. Its presence can significantly impact the safety and efficacy profiles of pharmaceutical products, making it relevant for regulatory compliance and drug development studies.

    Out of stock

    All 3 sizes
  • Donepezil impurity 6 hydrochloride
    Cat. No.
    B10091

    Donepezil impurity 6 hydrochloride

    Donepezil impurity 6 hydrochloride is a known impurity of the acetylcholinesterase inhibitor Donepezil hydrochloride. This compound is critical in the analysis of drug purity and assists in the characterization of donepezil formulations during research and development. Its presence is essential for quality control and safety assessments in the pharmaceutical industry.

    Out of stock

    All 3 sizes
  • Rivastigmine impurity 11
    Cat. No.
    B10170

    Rivastigmine impurity 11

    Rivastigmine impurity 11 is a known impurity of Rivastigmine, a reversible inhibitor of acetylcholinesterase. This compound is of significant interest for quality control and toxicological studies in pharmaceutical research. Its analysis is crucial for ensuring the purity and safety of Rivastigmine formulations, supporting compliance with regulatory standards in drug development.

    100 mg
    $20.00
    250 mg
    $35.00
    All 7 sizes
  • Donepezil impurity 13
    Cat. No.
    B10381

    Donepezil impurity 13

    Donepezil impurity 13 is a chemical impurity associated with Donepezil, a reversible inhibitor of acetylcholinesterase. It serves as an important reference standard in analytical chemistry for the assessment of pharmaceutical purity. This compound is utilized in the quality control and stability testing of Donepezil formulations, ensuring compliance with regulatory standards in drug development and manufacturing processes.

    Out of stock

    All 3 sizes
  • Rivastigmine impurity 5
    Cat. No.
    B10402

    Rivastigmine impurity 5

    Synonyms: Rivastigmine impurity F

    Rivastigmine impurity 5 is a designated impurity associated with the cholinesterase inhibitor Rivastigmine. This compound serves as a critical reference standard for quality control and analytical chemistry in pharmaceutical research. Its analysis is essential for ensuring the purity of Rivastigmine formulations, thereby supporting regulatory compliance and safety assessments in drug development.

    Out of stock

    All 3 sizes
  • Rivastigmine impurity 4
    Cat. No.
    B10434

    Rivastigmine impurity 4

    Synonyms: Rivastigmine impurity E

    Rivastigmine impurity 4 is a chemical impurity associated with Rivastigmine, a reversible inhibitor of acetylcholinesterase. This impurity is relevant in the quality control and analytical evaluation of Rivastigmine formulations. Research applications include pharmacokinetic studies and the assessment of drug stability.

    Out of stock

    All 3 sizes

Items 601-625 of 663

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