AChE

Cat. No.

A78844

CAS No.

194930-04-6

(Rac)-Rivastigmine-d6

Synonyms: (Rac)-ENA 713-d6 free base; (Rac)-SDZ-ENA 713-d6 free base

(Rac)-Rivastigmine-d6 is a stable isotope-labeled form of Rivastigmine, a potent inhibitor of cholinesterases, specifically butyrylcholinesterase (BChE) and acetylcholinesterase (AChE), with IC50 values of 0.037 μM and 4.15 μM, respectively. This compound effectively crosses the blood-brain barrier, making it a valuable tool for investigating cholinergic mechanisms.(Rac)-Rivastigmine-d6 is primarily utilized in research focused on mild to moderate Alzheimer's dementia and dementia associated with Parkinson's disease, facilitating studies on neurotransmission and therapeutic interventions.

Cat. No.

A78845

CAS No.

1011351-65-7

AE027

AE027 is a potent inhibitor of acetylcholinesterase (AChE), effectively targeting both wild-type and the resistant F348Y mutation, with IC50 values of 10 μM and 43 μM, respectively. This compound exhibits significant biological activity in blocking AChE, making it a valuable tool for research in neurodegenerative disorders and studies related to cholinergic signaling. AE027 provides potential insights into therapeutic strategies for conditions associated with AChE dysregulation.

Cat. No.

A78846

CAS No.

6882-09-3

Undulatine

Undulatine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 7.4 μM. This compound is capable of crossing the blood-brain barrier through passive permeation, making it a valuable tool for investigating the pathophysiology of Alzheimer's disease. Its ability to modulate cholinergic activity positions Undulatine as a promising candidate for research into therapeutic strategies for neurodegenerative disorders.

Cat. No.

A78847

CAS No.

86537-66-8

N-Methylcalycinine

N-Methylcalycinine is a natural product that acts as an acetylcholinesterase (AChE) inhibitor. Isolated from the roots of Stephania epigaea, it possesses potential therapeutic implications in various research fields, including asthma, cancer, dysentery, fever, hyperglycemia, intestinal disorders, inflammation, sleep disturbances, and tuberculosis. This compound may be valuable for studies exploring its effects on neurotransmitter regulation and related biological processes.

Cat. No.

A78848

CAS No.

360768-68-9

Samioside

Samioside is an acetylcholinesterase inhibitor primarily extracted from the plants Phlomis nissolii and P. capitata. It exhibits notable free-radical scavenging and antimicrobial properties, making it a valuable compound for biological research. Samioside is particularly relevant for studies investigating its potential anti-Alzheimer’s effects, offering insights into therapeutic avenues for neurodegenerative conditions.

Cat. No.

A78849

CAS No.

133920-70-4

FK960

FK960 is a cholinesterase activator with potential applications in anti-dementia therapy. It enhances cholinergic neurotransmission, effectively reversing the reduction in cerebral blood flow (rCBF) induced by sensory stimulation. In macaque studies, FK960 has demonstrated the ability to restore rCBF responses that were eliminated by treatment with physostigmine, lasting for up to one hour. Notably, FK960 does not restore rCBF responses affected by NMDA modulators, suggesting a targeted mechanism independent of non-glutamatergic pathways.

Cat. No.

A78851

CAS No.

390362-51-3

Buxbodine B

Buxbodine B is an acetylcholinesterase (AChE) inhibitor with an IC50 of 50 μM. It demonstrates significant potential in the study of neurodegenerative diseases, particularly Alzheimer's disease, by modulating cholinergic transmission. Its inhibitory action on AChE facilitates the exploration of therapeutic strategies aimed at enhancing cognitive function and memory retention in affected populations.

Cat. No.

A78852

CAS No.

261950-94-1

Arisugacin D

Arisugacin D is an acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 value of 3.5 μM. This compound is notable for its potential to enhance synaptic acetylcholine levels, making it useful in studies related to neurodegenerative diseases such as Alzheimer's. The inhibition of AChE facilitates the investigation of cholinergic signaling pathways and the development of therapeutic strategies targeting cognitive decline.

Cat. No.

A78854

CAS No.

2270876-07-6

AL284

AL284 is a potent inhibitor of Anopheles gambiae acetylcholinesterase 1 (AgAChE1), targeting key residues Tyr489Ag and Trp441Ag within the enzyme structure. This compound demonstrates significant biological activity in disrupting neurotransmitter breakdown, which is critical for the survival of disease-transmitting mosquitoes. AL284 is valuable for research applications focused on controlling mosquito populations and studying vector-borne diseases.

Cat. No.

A78855

CAS No.

588-17-0

Neostigmine hydroxide

Neostigmine hydroxide is a potent cholinesterase inhibitor that enhances acetylcholine levels at neuromuscular junctions. This compound is primarily utilized in research related to myasthenia gravis and other neuromuscular disorders, aiding in the exploration of muscular function and neuropharmacology. Its ability to counteract muscle weakness makes it a valuable tool for studying therapeutic interventions in cholinergic signaling.

Cat. No.

A78856

CAS No.

321-54-0

Coroxon

Synonyms: Coumaphos oxon

Coroxon, an AChE inhibitor, is an oxidative metabolite of the organophosphate insecticide Coumaphos. This compound exhibits significant insecticidal and acaricidal activity, making it valuable for pest control research. Additionally, Coroxon can be hydrolyzed by phosphotriesterases from microorganisms such as Nocardia asteroides, resulting in the production of the fluorescent compound Chlorferon, which can be utilized in biochemical assays and studies related to enzyme activity.

Cat. No.

A78857

CAS No.

261951-57-9

Arisugacin G

Arisugacin G, a microbial metabolite, acts as a structural analog of Arisugacin A. This compound demonstrates significant potential in research applications related to microbial biochemistry and the study of analogs in biological systems. Notably, Arisugacin G lacks activity against acetylcholinesterase (AChE), making it a candidate for investigations where AChE inhibition is not desired.

Cat. No.

A78858

CAS No.

444179-57-1

Salvianolic acid H

Salvianolic acid H is a potent inhibitor of acetylcholinesterase (AChE), serving to enhance cholinergic neurotransmission. Its primary biological activity includes the potential modulation of neurodegenerative processes associated with cognitive decline. This compound is valuable for research applications aimed at understanding Alzheimer's disease and other conditions linked to cholinergic deficits.

Cat. No.

A78859

CAS No.

125-51-9

Pipenzolate bromide

Pipenzolate bromide is a muscarinic receptor antagonist that functions by inhibiting cholinesterase (ChE) activity, thereby preventing the binding of acetylcholine to its receptors. This compound exhibits significant anticholinergic properties, making it valuable in pharmacological research related to disorders such as motion sickness, asthma, and gastrointestinal motility. Pipenzolate bromide serves as a useful reagent in studies aimed at understanding the modulation of cholinergic signaling pathways.

Cat. No.

A78860

CAS No.

5778-80-3

7-Methoxytacrine

Synonyms: 7-MEOTA

7-Methoxytacrine is a potent inhibitor of human acetylcholinesterase (hAChE) with an IC50 value of 10 μM. This compound is utilized in research related to Alzheimer's disease, highlighting its potential role in modulating neurotransmitter levels and improving cognitive function. Its mechanism of action makes it a valuable tool for investigating therapeutic strategies in neurodegenerative disorders.

Cat. No.

A78861

CAS No.

126-75-0

Demeton-S

Demeton-S is an organophosphate insecticide that primarily targets butyrylcholinesterase and acetylcholinesterase enzymes. By inhibiting these enzymes, Demeton-S disrupts cholinergic neurotransmission, leading to paralysis and mortality in insects. This compound is utilized in agricultural research and pest management studies to evaluate insect resistance and to develop sustainable control strategies.

Cat. No.

A78863

CAS No.

119229-64-0

HP 184

HP 184 is an acetylcholine release stimulator, functioning as a cholinesterase (ChE) activator. This compound enhances synaptic transmission by promoting the release of acetylcholine, making it valuable for studies in neurobiology and neuromuscular disorders. Additionally, the compound's ADME properties can be modified by substituting hydrogen with deuterium, allowing for further exploration of its pharmacokinetics and pharmacodynamics in research applications.

Cat. No.

A78864

CAS No.

261951-22-8

Arisugacin E

Arisugacin E is a microbial metabolite with a structural similarity to Arisugacin A. This compound has been characterized for its unique biological properties but does not exhibit activity against acetylcholinesterase (AChE). Arisugacin E may serve as a useful tool for studying microbial metabolites and their role in biochemical pathways within various research applications.

Cat. No.

A78865

CAS No.

20316-18-1

Lycodine

Lycodine is a lycopodium alkaloid that acts as a cholinesterase inhibitor. It demonstrates significant anticholinesterase activity, making it a valuable tool for research into neurological disorders and cognitive function. Its potential applications extend to studying mechanisms of acetylcholine modulation and developing therapeutic approaches for conditions such as Alzheimer’s disease.

Cat. No.

A78866

CAS No.

52179-44-9

Graphislactone A

Graphislactone A is an acetylcholinesterase (AChE) inhibitor, which demonstrates significant potential in the investigation of neurodegenerative diseases. With an IC50 value of 27 μM, it effectively inhibits AChE activity, contributing to enhanced cholinergic signaling. Additionally, Graphislactone A exhibits antioxidant properties, making it a valuable compound for research focused on oxidative stress-related disorders.

Cat. No.

A78867

CAS No.

432-68-8

Echinenone

Echinenone acts as an acetylcholinesterase (AChE) inhibitor, exhibiting an IC50 value of 16.29 μg/mL. This compound demonstrates anti-Aβ(25-35) activity and has been shown to decrease malondialdehyde (MDA) levels while enhancing the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). These properties indicate its potential use in research focused on neuroprotection and alleviating oxidative stress-related damage.

Cat. No.

A78869

CAS No.

261951-59-1

Arisugacin H

Arisugacin H is a microbial metabolite that functions as a structural analog of Arisugacin A. This compound exhibits notable biological activity, primarily contributing to the study of microbial interactions and metabolites. Although it has been characterized, it does not demonstrate inhibition of acetylcholinesterase (AChE), making it a useful tool for exploring alternative pathways in microbial research.

Cat. No.

A78870

CAS No.

3344-11-4

Isodimethoate

Isodimethoate is an acetylcholinesterase (AChE) inhibitor that demonstrates potent anticholinesterase activity. As a thermal decomposition product of Dimethoate, it effectively inhibits AChE in human red blood cells, making it valuable for studying cholinergic signaling and related neurochemical pathways. This compound is frequently utilized in research focused on neurotoxicology and the effects of organophosphates on enzymatic activity.

Cat. No.

A78872

CAS No.

40626-35-5

Heterophos

Synonyms: Heterofos

Heterophos is an organophosphorus insecticide that functions as an acetylcholinesterase (AChE) inhibitor. By disrupting the normal breakdown of acetylcholine, Heterophos leads to the accumulation of this neurotransmitter, resulting in disturbances of nerve conduction in insects. This mechanism underpins its efficacy in pest control applications, particularly in the study of insect neurophysiology and insecticide resistance mechanisms.

Cat. No.

A78873

CAS No.

31049-08-8

Dihydrokaempferol-3-O-β-D-glucoside

Dihydrokaempferol-3-O-β-D-glucoside is a natural product that acts as an inhibitor of acetylcholinesterase (AChE). Isolated from the bark of Cudrania tricuspidata, this compound demonstrates potential biological activity in modulating cholinergic signaling. Its research applications include studies on neurodegenerative diseases and exploration of cognitive enhancement mechanisms.