AChE

Cat. No.

A78580

CAS No.

5336-90-3

9-Acridinecarboxylic acid

9-Acridinecarboxylic acid is a potent cholinesterase (ChE) inhibitor, acting on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). It serves as a precursor for various derivatives that exhibit nanomolar inhibitory activity. This compound is crucial for research in neurodegenerative diseases and provides insights into the modulation of cholinergic signaling pathways.

Cat. No.

A78581

CAS No.

209394-18-3

Ladostigil hydrochloride

Synonyms: TV-3326 hydrochloride

Ladostigil hydrochloride is a potent dual inhibitor of acetylcholinesterase (AChE) and monoamine oxidase-B (MAO-B), exhibiting IC50 values of 37.1 µM and 31.8 µM, respectively. This compound demonstrates neuroprotective, antioxidant, and anti-inflammatory properties, making it valuable for research related to depression and Alzheimer's disease. Additionally, Ladostigil hydrochloride functions as a click chemistry reagent, featuring an alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating diverse chemical applications.

Cat. No.

A78582

CAS No.

25650-68-4

Ebeiedinone

Ebeiedinone is a steroidal alkaloid obtained from Fritillaria species that functions as a cholinesterase (ChE) inhibitor. At a concentration of 0.1 mM, it demonstrates a substantial inhibitory effect of 69.0% on human whole blood cholinesterase activity. This compound is valuable for research involving neuropharmacology and the study of cholinergic signaling pathways.

Cat. No.

A78585

CAS No.

98704-22-4

AChE-IN-65

AChE-IN-65 is a mixed inhibitor of acetylcholinesterase (AChE) with a Ki of 556.4 μM, demonstrating potency against the AChE from Electrophorus electricus. This compound is valuable for research applications focused on the modulation of cholinergic signaling and the study of neurodegenerative diseases. AChE-IN-65 can aid in understanding the role of AChE in synaptic transmission and its potential as a therapeutic target.

Cat. No.

A78586

CAS No.

142698-19-9

(R)-Donepezil

Synonyms: (R)-E2020 free base

(R)-Donepezil is a specific and potent inhibitor of acetylcholinesterase (AChE). As the R-enantiomer of Donepezil, it demonstrates notable efficacy in enhancing cholinergic neurotransmission. This compound is primarily utilized in neuropharmacological research, particularly in studies related to Alzheimer's disease and other cognitive disorders, where modulation of AChE activity is critical for therapeutic development.

Cat. No.

A78587

CAS No.

5589-41-3

Dihydrowithaferin A

Synonyms: 2,3-Dihydrowithaferin A

Dihydrowithaferin A is a withanolide derived from Withania somnifera, acting primarily as an acetylcholinesterase (AChE) inhibitor. This compound demonstrates significant biological activity by modulating cholinergic transmission, making it useful in research related to neurodegenerative disorders such as Alzheimer’s disease. Its ability to inhibit AChE positions Dihydrowithaferin A as a valuable tool in the exploration of therapeutic approaches targeting cholinergic dysfunction.

Cat. No.

A78588

CAS No.

142057-80-5

(S)-Donepezil

Synonyms: (S)-E2020 free base

(S)-Donepezil is an S-enantiomer of Donepezil, serving as a specific and potent inhibitor of acetylcholinesterase (AChE). This compound enhances cholinergic neurotransmission by preventing the degradation of acetylcholine, making it a valuable tool in neuropharmacological research. It is primarily utilized in studies related to neurodegenerative diseases, particularly Alzheimer's disease, where modulation of AChE activity is of significant interest.

Cat. No.

A78589

CAS No.

6297-14-9

AChE-IN-23

AChE-IN-23 is a potent acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 value of 48.3 μM. This compound effectively inhibits the breakdown of acetylcholine, thereby enhancing cholinergic signaling. AChE-IN-23 has potential applications in research focused on neurological disorders, including Alzheimer's disease and other conditions associated with cholinergic dysfunction.

Cat. No.

A78590

CAS No.

1088-17-1

Isomerazin

Isomerazin is a coumarin compound known for its inhibitory effects on cholinesterase (ChE). This compound has demonstrated significant biological activity in the modulation of cholinergic neurotransmission, making it valuable for research into neurodegenerative diseases and cognitive disorders. Its application in studies related to Alzheimer's disease further highlights its potential as a therapeutic agent in cholinergic system-related research.

Cat. No.

A78591

CAS No.

366448-34-2

Serine Hydrolase inhibitor-21

Serine Hydrolase Inhibitor-21 is a potent inhibitor of serine hydrolases, exhibiting a Ki value of 429 nM for butyrylcholinesterase (BuChE). This compound is particularly relevant for research into Alzheimer’s disease, as it may help to elucidate the role of serine hydrolase activity in neurodegeneration. Its mechanism of action may provide insights into potential therapeutic strategies for the treatment of Alzheimer's and related disorders.

Cat. No.

A78598

CAS No.

263248-42-6

Zanapezil fumarate

Synonyms: TAK-147 fumarate

Zanapezil fumarate is a potent, reversible, and selective inhibitor of acetylcholine esterase (AChE). It exhibits significant inhibition of AChE activity in rat cerebral cortex homogenates, with an IC50 value of 51.2 nM, while also displaying moderate inhibition of muscarinic M1 and M2 receptor binding, with Ki values of 234 and 340 nM respectively. This compound is utilized in research focusing on the early stages of Alzheimer's disease, aiding in the exploration of therapeutic strategies for cognitive decline.

Cat. No.

A78600

CAS No.

123702-95-4

Kuwanon U

Kuwanon U is a potent cholinesterase inhibitor that demonstrates effective inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 19.69 µM and 10.11 µM, and inhibition constants (Ki) of 6.48 µM and 9.59 µM, respectively. This compound shows promise for research applications concerning Alzheimer’s disease (AD), providing a valuable tool for studying cholinergic function and neurodegeneration.

Cat. No.

A78601

CAS No.

164724-79-2

P11149

P11149 is a competitive inhibitor of acetylcholinesterase (AChE) that exhibits weak oral bioavailability and the ability to penetrate the blood-brain barrier. With an IC50 of 1.3 μM against rat butyrylcholinesterase (BChE) and AChE, P11149 displays significant cholinergic activity and behavioral efficacy. This Galanthamine derivative is primarily used in research related to Alzheimer's disease, aiding in the exploration of therapeutic strategies for cognitive impairment associated with this neurodegenerative disorder.

Cat. No.

A78602

CAS No.

134332-50-6

Galanthamine N-Oxide

Galanthamine N-Oxide is an acetylcholinesterase (AChE) inhibitor derived from the bulbs of Zephyranthes concolor. It exhibits a potent inhibitory effect on electric eel AChE with an EC50 value of 26.2 μM. Additionally, Galanthamine N-Oxide effectively hampers substrate accommodation in the active sites of Torpedo californica AChE, human AChE, and human butyrylcholinesterase (hBChE), making it a valuable tool for research in neuropharmacology and cholinergic signaling pathways.

Cat. No.

A78603

CAS No.

60755-80-8

O-Desmethyl Galanthamine

Synonyms: Sanguinine

O-Desmethyl Galanthamine is an acetylcholinesterase (AChE) inhibitor with an IC50 of 1.83 μM. As a galanthamine-type alkaloid, it effectively modulates cholinergic signaling by preventing the breakdown of acetylcholine. This compound is primarily utilized in research focused on neurodegenerative diseases, including Alzheimer's disease, where AChE inhibition is of therapeutic interest.

Cat. No.

A78604

CAS No.

6735-59-7

Pralidoxime

Pralidoxime is a potent reactivator of acetylcholinesterase (AChE), targeting the recovery of enzyme activity inhibited by nerve agents. It functions through a direct nucleophilic attack by its oxime moiety on the phosphorus atom of the bound inhibitor, effectively reversing the effects of organophosphate poisoning. Pralidoxime is utilized in various research applications focused on neurotoxicology and antidote development.

Cat. No.

A78605

CAS No.

209394-27-4

Ladostigil

Synonyms: TV-3326

Ladostigil is a dual inhibitor of monoamine oxidase (MAO) and acetylcholinesterase (AChE), demonstrating IC50 values of 37.1 μM for MAO-B and 31.8 μM for AChE. This compound exhibits neuroprotective, antioxidant, and anti-inflammatory properties, making it valuable for research in conditions such as depression and Alzheimer's disease. Additionally, Ladostigil features an alkyne functional group, enabling it to serve as a click chemistry reagent through copper-catalyzed azide-alkyne cycloaddition (CuAAc).

Cat. No.

A78606

CAS No.

16088-19-0

Norneostigmine

Norneostigmine is a potent inhibitor of acetylcholinesterase (AChE) with the ability to penetrate the blood-brain barrier. It demonstrates a 50% inhibition of mouse brain AChE within 10 minutes of treatment, exhibiting efficacy comparable to other known AChE inhibitors. This reagent is valuable for investigating memory disorders, including Alzheimer's disease and related cognitive impairments, facilitating research into potential therapeutic strategies.

Cat. No.

A78607

CAS No.

142852-51-5

Zanapezil

Synonyms: TAK-147

Zanapezil is a potent, reversible, and selective inhibitor of acetylcholine esterase (AChE). With an IC50 of 51.2 nM in rat cerebral cortex homogenates, Zanapezil effectively inhibits AChE activity, while also demonstrating moderate inhibition of muscarinic M1 and M2 receptor binding, with Ki values of 234 nM and 340 nM, respectively. This compound serves as a valuable tool for research focused on the early stages of Alzheimer's disease (AD).

Cat. No.

A78608

CAS No.

73731-87-0

Broussonin A

Broussonin A is a potent butyrylcholinesterase (BChE) inhibitor, exhibiting an IC50 of 4.16 µM. This diarylpropane natural product is derived from the bark of Broussonetia papyrifera through solid fermentation processes. Broussonin A is primarily utilized in research investigating neurodegenerative diseases and the modulation of cholinergic signaling pathways. Its inhibitory activity makes it a valuable tool for studying the role of BChE in various biological contexts.

Cat. No.

A78609

CAS No.

94492-23-6

Osmanthuside B

Osmanthuside B is an acetylcholinesterase inhibitor derived from Pseuderanthemum carruthersii (Seem.) Guill. var. atropurpureum (Bull.) Fosb. This compound exhibits weak inhibitory activity against acetylcholinesterase, making it a valuable tool for research into neurotransmission processes and potential therapeutic applications in neurodegenerative diseases. Its effects on cholinergic signaling pathways can provide insights into mechanisms of action for various biochemical studies.

Cat. No.

A78610

CAS No.

142852-50-4

Zanapezil free base

Synonyms: TAK-147 free base

Zanapezil free base is a potent, reversible, and selective inhibitor of acetylcholine esterase (AChE). It demonstrates significant AChE activity inhibition in homogenates of the rat cerebral cortex, with an IC50 value of 51.2 nM. Additionally, Zanapezil exhibits moderate inhibition of muscarinic M1 and M2 receptor binding, with Ki values of 234 nM and 340 nM, respectively. This compound is suitable for research focused on the early stages of Alzheimer's disease, contributing to the understanding of cholinergic dysfunction in neurodegenerative disorders.

Cat. No.

A78613

CAS No.

118909-22-1

Velnacrine maleate

Synonyms: HP 029; Hydroxytacrine maleate

Velnacrine maleate is an orally active cholinesterase inhibitor that targets the enzyme acetylcholinesterase, thus increasing acetylcholine levels in the brain. This compound is primarily utilized in research studying Alzheimer's disease and its associated cognitive decline. Through modulation of cholinergic neurotransmission, Velnacrine maleate provides insights into potential therapeutic strategies for neurological disorders.

Cat. No.

A78614

CAS No.

866245-79-6

Octahydroaminoacridine succinate

Octahydroaminoacridine succinate is a potent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). This compound is primarily utilized in Alzheimer's disease research, where modulation of cholinergic activity plays a crucial role in therapeutic strategies. Its ability to effectively inhibit these enzymes makes it a valuable tool for understanding the underlying mechanisms of neurodegeneration and developing potential treatments.

Cat. No.

A78615

CAS No.

1334106-34-1

ASS234

ASS234 is a potent monoamine oxidase (MAO) inhibitor, targeting MAO-A and MAO-B with IC50 values of 5.2 nM and 43 nM, respectively. In addition to its primary activity, ASS234 also exhibits inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with IC50 values of 350 nM and 460 nM, respectively. This compound can be utilized in research related to neurodegenerative diseases, mood disorders, and cholinergic signaling pathways.