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| Catalog No. | Inhibitor Name | PDK-1 | Other Targets |
|---|---|---|---|
| A10681 | OSU-03012 | ** | |
| A11148 | BX-795 | **** | TBK1/IKKɛ,c-Kit,CDK2/CyclinE |
| A11149 | BX-912 | *** | PKA,KDR,CDK2/CyclinE |
| A11032 | PHT-427 | * | Akt |
| A12767 | GSK2334470 | *** | |
| A12881 | BX-517 | **** | |
| A11511 | NVP-BAG956 | * | PI3K |
| A13484 | PS 48 | * |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
13 Item(s)
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BX-795
Catalog No. A11148 PDK-1 inhibitorBX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis. Learn More -
PDK1 inhibitor
Catalog No. A11528 PDK1 inhibitorPDK1 inhibitor is a potent and selective inhibitor of PDK1 with potential as anticancer agent. Learn More -
PDK1 inhibitor
Catalog No. A16185 PDK1 inhibitorPDK1 inhibitor, potent, ATP-competitive and selective dual PI3K and PDPK1 inhibitor (IC50 values 34 nM and 94 nM for PDK1 and p-T308-PKB inhibition, respectively. Learn More -
PS210
Catalog No. A22109 protein kinase PDK1 inhibitorPS210 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site. Learn More -
PHT-427
Catalog No. A11032 AKT InhibitorPHT-427 is a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Learn More -
OSU-03012
Catalog No. A10681 PDK-1 inhibitorOSU-03012 is a novel celecoxib derivative, without cyclooxygenase-2 inhibitory activity, capable of inducing apoptosis in various cancer cells types. Learn More -
BX-912
Catalog No. A11149 PDK1 inhibitorBX-912 is an inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1). Learn More -
NVP-BAG956
Catalog No. A11511 PI3K/PDK-1 InhibitorNVP-BAG956 acts as a potent, reversible, and ATP-competitive PI 3-K/PDK1 dual kinase inhibitor, displaying much reduced potency against VEGFR1 (IC50 = 2.56 uM) and little or no activity toward a panel of 15 other kinases (IC50 >10 uM). Learn More -
GSK 2334470
Catalog No. A12767 PDK1 InhibitorGSK 2334470 is a potent 3-phosphoinositide-dependent protein kinase (PDK1) inhibitor (IC50 ~ 10 nM). Learn More -
PS 48
Catalog No. A13484 PDK1 activatorPS 48 is an allosteric phosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd = 10.3 μM). Learn More -
BX-517
Catalog No. A12881 PDK1 inhibitorBX-517 is a potent and selective inhibitor of PDK1 that binds to the ATP binding pocket of the protein (IC50 = 6 nM). Learn More -
TEPP-46
Catalog No. A16279 PKM2 activatorTEPP-46 is a potent and selective activator of recombinant pyruvate kinase M2 (PKM2) with half-maximum activating concentration (AC50 value) of 92 nM, and little or no activity versus PKM1, PKL and PKR. Learn More -
KPLH1130
Catalog No. A18494 PDK inhibitorKPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses. KPLH1130 improves glucose tolerance in HFD-fed mice. Learn More
13 Item(s)
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