PDK1

Catalog No.Inhibitor Name PDK-1 Other Targets
A10681OSU-03012
**
A11148BX-795
****
TBK1/IKKɛ,c-Kit,CDK2/CyclinE
A11149BX-912
***
PKA,KDR,CDK2/CyclinE
A11032PHT-427
*
Akt
A12767GSK2334470
***
A12881 BX-517
****
A11511NVP-BAG956
*
PI3K
A13484PS 48
*

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. PDK1 inhibitor

    Catalog No. A16185
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    PDK1 inhibitor
    PDK1 inhibitor, potent, ATP-competitive and selective dual PI3K and PDPK1 inhibitor (IC50 values 34 nM and 94 nM for PDK1 and p-T308-PKB inhibition, respectively. Learn More
  2. PDK1 inhibitor

    Catalog No. A11528
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    PDK1 inhibitor
    PDK1 inhibitor is a potent and selective inhibitor of PDK1 with potential as anticancer agent. Learn More
  3. PHT-427

    Catalog No. A11032
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    AKT Inhibitor
    PHT-427 is a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Learn More
  4. BX-517

    Catalog No. A12881
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    PDK1 inhibitor
    BX-517 is a potent and selective inhibitor of PDK1 that binds to the ATP binding pocket of the protein (IC50 = 6 nM). Learn More
  5. PS 48

    Catalog No. A13484
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    PDK1 activator
    PS 48 is an allosteric phosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd = 10.3 μM). Learn More
  6. GSK 2334470

    Catalog No. A12767
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    PDK1 Inhibitor
    GSK 2334470 is a potent 3-phosphoinositide-dependent protein kinase (PDK1) inhibitor (IC50 ~ 10 nM). Learn More
  7. NVP-BAG956

    Catalog No. A11511
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    PI3K/PDK-1 Inhibitor
    NVP-BAG956 acts as a potent, reversible, and ATP-competitive PI 3-K/PDK1 dual kinase inhibitor, displaying much reduced potency against VEGFR1 (IC50 = 2.56 uM) and little or no activity toward a panel of 15 other kinases (IC50 >10 uM). Learn More
  8. BX-912

    Catalog No. A11149
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    PDK1 inhibitor
    BX-912 is an inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1). Learn More
  9. BX-795

    Catalog No. A11148
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    PDK-1 inhibitor
    BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis. Learn More
  10. OSU-03012

    Catalog No. A10681
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    PDK-1 inhibitor
    OSU-03012 is a novel celecoxib derivative, without cyclooxygenase-2 inhibitory activity, capable of inducing apoptosis in various cancer cells types. Learn More
  11. TEPP-46

    Catalog No. A16279
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    PKM2 activator
    TEPP-46 is a potent and selective activator of recombinant pyruvate kinase M2 (PKM2) with half-maximum activating concentration (AC50 value) of 92 nM, and little or no activity versus PKM1, PKL and PKR. Learn More

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