DPP-4

Cat. No.

A43514

CAS No.

1359670-56-6

Anagliptin hydrochloride

Synonyms: SK-0403 hydrochloride

Anagliptin hydrochloride is a potent and selective inhibitor of dipeptidyl peptidase 4 (DPP-4), exhibiting an IC50 of 3.8 nM. It demonstrates reduced selectivity for DPP-8 and DPP-9, with IC50 values of 68 nM and 60 nM, respectively. This compound is utilized in research focused on glycemic control and has applications in studying Type 2 diabetes and related metabolic disorders.

Cat. No.

A43516

CAS No.

3020859-44-0

DPP9-IN-2

DPP9-IN-2 is a selective, potent inhibitor of Dipeptidyl Peptidase 9 (DPP9), exhibiting an IC50 of 12.9 nM. It demonstrates a selectivity index of 59 over DPP8 and shows minimal inhibitory effects on related peptidases, including DPP2, DPP4, FAP, and PREP. DPP9-IN-2 has been shown to induce pyroptosis in cancer cells and exhibits weak synergistic anti-HIV-1 activity when combined with non-nucleoside reverse transcriptase inhibitors. This compound is suitable for research related to cancer and infectious diseases.

Cat. No.

A43517

CAS No.

207556-62-5

NVP-DPP728 dihydrochloride

NVP-DPP728 dihydrochloride is a selective and potent inhibitor of dipeptidyl peptidase IV (DPP-IV), with a Ki value of 11 nM. This compound plays a critical role in the regulation of glucose metabolism and is utilized in research related to diabetes mellitus. NVP-DPP728 dihydrochloride offers valuable insights into the therapeutic potential of DPP-IV inhibition in glycemic control and metabolic diseases.

Cat. No.

A43518

CAS No.

1601480-12-9

ZY15557

ZY15557 is a novel competitive DPP-4 inhibitor with a Ki of 5.53 nM, demonstrating significant potency in inhibiting plasma DPP-4 activity. This orally active compound is useful in the investigation of type 2 diabetes and its potential therapeutic strategies. Research applications include studying glucose metabolism and insulin secretion modulation associated with DPP-4 inhibition.

Cat. No.

A43519

CAS No.

929105-33-9

RBx-0597

RBx-0597 is a selective inhibitor of Dipeptidyl Peptidase IV (DPP-IV), exhibiting IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. This compound shows promise in the investigation of type 2 diabetes by modulating glucose metabolism and incretin levels, making it a valuable tool for diabetes research and related metabolic studies.

Cat. No.

A43520

CAS No.

54495-98-6

O-Benzoylhydroxylamine

O-Benzoylhydroxylamine is a selective inhibitor of Dipeptidyl Peptidase IV (DPP-IV), a key enzyme involved in glucose metabolism. By inhibiting DPP-IV, this compound exhibits significant anti-diabetic effects, making it valuable for research into diabetes management and related metabolic disorders. Its mechanisms and targets are critical for understanding the pathways influenced by DPP-IV inhibition.

Cat. No.

A43521

CAS No.

851389-35-0

ASP4000 hydrochloride

ASP4000 hydrochloride is a potent, selective inhibitor of dipeptidyl peptidase IV (DPP4), exhibiting an IC50 value of 2.25 nM against human recombinant DPP4. This compound demonstrates significant antihyperglycemic effects, making it valuable in studies related to type 2 diabetes research. Its oral bioavailability and competitive inhibition profile allow for potential applications in understanding DPP4's role in glucose metabolism and diabetes management.

Cat. No.

A43523

CAS No.

872861-28-4

ZINC000003015356

ZINC000003015356 is a DPP4 inhibitor that selectively blocks the activity of the dipeptidyl peptidase-4 enzyme. This inhibition enhances the availability of incretin hormones, which are crucial for glucose metabolism. ZINC000003015356 is primarily used in research related to diabetes and metabolic disorders, contributing to studies focused on glycemic control and potential therapeutic strategies.

Cat. No.

A43524

CAS No.

54249-88-6

Dipeptidyl Peptidase IV, Porcine Kidney

Synonyms: DPP-IV; Porcine Kidney

Dipeptidyl Peptidase IV, Porcine Kidney is a serine aminopeptidase that plays a vital role in glucose metabolism. This enzyme specifically hydrolyzes gastric inhibitory peptide (GIP) and glucagon-like peptide-1 (GLP-1), which are key incretins involved in insulin release regulation. Its biological activity makes it a valuable tool for research in diabetes, metabolism, and related endocrine functions.

Cat. No.

A43525

CAS No.

856170-98-4

H-Pro-Pro-Gln-OH

H-Pro-Pro-Gln-OH is an oligopeptide that acts as a potent inhibitor of dipeptidyl peptidase-IV (DPP-IV). This compound exhibits significant biological activity in modulating insulin secretion and glucose metabolism, making it a valuable tool for diabetes research. Its effective inhibition of DPP-IV may contribute to therapeutic strategies in managing type 2 diabetes and related metabolic disorders.

Cat. No.

A43526

CAS No.

3020859-80-4

DPP-8/9 probe-1

DPP-8/9 probe-1 is a selective inhibitor targeting Dipeptidyl Peptidase DPP8/9, designed for use in fluorescence microscopy. This fluorescent probe features a nitrobenzoxadiazole (NBD) tag, demonstrating high affinity for DPP8/9 with an IC50 of 15 nM, while showing minimal activity against related S9 family members (IC50 of 210 nM). DPP-8/9 probe-1 enables visualization of active DPP8/9 in vitro, making it a valuable tool for studying the biological functions and pathways associated with this enzyme in research settings.

Cat. No.

A43527

CAS No.

2971064-13-6

Florensocatib hydrate

Florensocatib hydrate is a potent inhibitor of dipeptidyl peptidase I (DPP1) with an IC50 value of 1.6 nM. This compound exhibits favorable bioavailability and pharmacokinetic properties, making it suitable for studies investigating inflammatory diseases and related pathophysiological processes. Its ability to modulate DPP1 activity provides a valuable tool for understanding disease mechanisms and exploring potential therapeutic strategies.

Cat. No.

A43529

CAS No.

913978-37-7

AMG-222

AMG-222 is a dipeptidyl peptidase IV (DPP-IV) inhibitor that reversibly binds to the enzyme, thereby inhibiting its activity. This compound demonstrates a saturable and concentration-dependent binding to human plasma proteins, achieving a binding rate of 80.8% at 1 nM and decreasing to 29.4% at concentrations above 100 nM. AMG-222 is primarily utilized in diabetes research, aiding studies focused on glucose metabolism and insulin regulation.

Cat. No.

A43530

CAS No.

3034173-09-3

Invobenitug

Invobenitug is a humanized IgG1κ antibody that specifically targets dipeptidyl peptidase 3 (DPP3). This antibody is primarily utilized in research applications focused on understanding the role of DPP3 in various physiological and pathological processes. Its specificity and affinity make it an essential tool for studies related to cellular signaling, metabolism, and disease mechanisms involving DPP3.

Cat. No.

A43531

CAS No.

915729-95-2

BMS-767778

BMS-767778 is a selective DPP4 inhibitor, exhibiting high affinity with Ki values of 0.94 nM for DPP4, and 4.9 nM and 3.2 nM for DPP8 and DPP9, respectively, demonstrating over 3,000-fold selectivity against these related enzymes. This compound also inhibits CYP-3A4 with an IC50 of 5.2 μM. BMS-767778 has been shown to significantly lower blood glucose levels in high-fat diet-induced ob/ob mouse models, indicating its potential for diabetes mellitus research applications.

Cat. No.

A43532

CAS No.

2215027-46-4

DPP-4-IN-1

DPP-4-IN-1 is a potent inhibitor of dipeptidyl peptidase 4 (DPP-4) with an IC50 of 49 nM. This compound, structurally analogous to Alogliptin, plays a crucial role in regulating glucose metabolism and enhancing insulin secretion. DPP-4-IN-1 is essential for diabetes research, facilitating investigations into therapeutic strategies for managing hyperglycemia.

Cat. No.

A43533

CAS No.

811432-66-3

Denagliptin tosylate

Denagliptin tosylate is a tosyate salt of Denagliptin, functioning as a potent dipeptidyl peptidase IV (DPP-4) inhibitor. This small molecule effectively enhances incretin levels, contributing to improved glycemic control in type 2 diabetes models. Its applications in research include investigating mechanisms of insulin secretion and glucose metabolism, making it a valuable tool for diabetes-related studies.

Cat. No.

A43534

CAS No.

2906243-39-6

DPP-4-IN-9

DPP-4-IN-9 is a potent inhibitor of dipeptidyl peptidase 4 (DPP-4) with an IC50 of 8.22 nM. This compound exhibits significant antihyperglycemic activity, making it a valuable tool for research in diabetes and metabolic disorders. DPP-4-IN-9 is suitable for studies aimed at understanding the role of DPP-4 in glucose metabolism and the development of therapeutic agents targeting this pathway.

Cat. No.

A43535

CAS No.

869490-47-1

Gosogliptin hydrochloride

Gosogliptin hydrochloride is a selective, competitive inhibitor of DPP-IV, an enzyme crucial for the degradation of incretin peptides such as GLP-1 and glucose-dependent insulinotropic polypeptide. This compound exhibits rapid and reversible inhibition of plasma DPP-4 activity, leading to enhanced insulin secretion and improved glucose tolerance. Gosogliptin hydrochloride is primarily utilized in research focused on diabetes and metabolic disorders, providing valuable insights into glucose regulation and insulin dynamics.

Cat. No.

A43537

CAS No.

841302-51-0

BMS-538305 hydrochloride

BMS-538305 hydrochloride is a potent and selective inhibitor of dipeptidyl peptidase IV (DPP-IV), exerting its biological activity through the formation of a reversible covalent complex with the enzyme. The mechanism of action involves the covalent binding between the nitrile carbon of BMS-538305 and the enzyme residue S630, as revealed by X-ray crystal structure analysis. This compound is primarily utilized in research related to glucose metabolism and diabetes management, making it valuable for studies focused on metabolic disorders and therapeutic development.

Cat. No.

A43539

CAS No.

2762114-61-2

Florensocatib

Florensocatib is a potent inhibitor of Dipeptidyl Peptidase I (DPP1), a key enzyme involved in the processing of pro-inflammatory cytokines. This compound exhibits significant biological activity, making it a valuable tool for research in bronchiectasis and related inflammatory diseases. Its selective inhibition of DPP1 provides insights into therapeutic strategies aimed at modulating immune responses.

Cat. No.

A43541

CAS No.

2133900-95-3

DPP-4-IN-2

DPP-4-IN-2 is a potent inhibitor of dipeptidyl peptidase 4 (DPP-4) with an IC50 of 79 nM. This compound serves as a structural analog of Alogliptin and is primarily utilized in diabetes research. DPP-4-IN-2 facilitates the investigation of glucose metabolism and insulin signaling pathways, making it a valuable tool for understanding the pathophysiology of type 2 diabetes and developing potential therapeutic strategies.

Cat. No.

A43542

CAS No.

813452-18-5

Carmegliptin

Synonyms: RO-4876904

Carmegliptin is a potent and orally active DPP-IV inhibitor, demonstrating an IC50 value of 6.8 nM for human DPP-IV. By binding to the S1 pocket of DPP-IV, it effectively inhibits the degradation of GLP-1, leading to increased plasma insulin levels, improved glucose tolerance, and alleviation of hyperglycemia. Carmegliptin serves as a substrate for human P-glycoprotein without inhibiting the transporter, exhibiting low in vitro cell permeability. This compound is valuable for research focused on type 2 diabetes and non-insulin-dependent diabetes mellitus.

Cat. No.

A43543

CAS No.

2781135-27-9

DPP-1-IN-1

DPP-1-IN-1 is a potent inhibitor of Cathepsin C (Dipeptidyl peptidase I) with an IC50 of 5.31 nM. It effectively inhibits the activity of Cathepsin C, subsequently affecting Neutrophil elastase in neutrophils. This compound is valuable for research in the field of inflammatory diseases, providing insights into mechanisms of inflammation and potential therapeutic pathways.

Cat. No.

A43548

CAS No.

907609-33-0

TAK-100

TAK-100 is a selective, orally active dipeptidyl peptidase IV (DPP-4) inhibitor, exhibiting an IC50 of 5.3 nM. This compound demonstrates minimal inhibitory effects on other dipeptidyl peptidases, highlighting its specificity. TAK-100 is primarily utilized in research focused on diabetes, facilitating the exploration of glucose metabolism and insulin regulation.