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E3 Ligase Ligands

E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.

Cat. No.

A80889

CAS No.

2925082-63-7

CRBN ligand-314

CRBN ligand-314 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN for targeted protein degradation. This compound can be combined with a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera), a valuable tool in the study of protein function and turnover in cellular processes. Its applications include research on targeted therapy and novel drug development strategies in oncology and other disease areas.

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Cat. No.

A80890

CAS No.

2925073-31-8

CRBN ligand-429

CRBN ligand-429 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein for targeted protein degradation applications. This compound can be effectively conjugated to a target protein ligand using a linker, enabling the formation of PROTAC (proteolysis-targeting chimeras) molecules. It serves as a valuable tool in the study of targeted degradation pathways and has potential utility in therapeutic research focused on modulating protein levels within cellular systems.

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Cat. No.

A80891

CAS No.

3036607-71-0

CRBN ligand-164

CRBN ligand-164 is a selective ligand for the CRBN E3 ubiquitin ligase, facilitating the ubiquitination of target proteins. This compound is instrumental in the development of PROTACs (proteolysis-targeting chimeras), which harness the ubiquitin-proteasome system to selectively degrade proteins of interest. Its ability to induce targeted protein degradation makes CRBN ligand-164 valuable in drug discovery and therapeutic research.

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Cat. No.

A80892

CAS No.

2412058-81-0

CRBN ligand-221

CRBN ligand-221 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in protein degradation pathways. This compound can be conjugated to a target protein ligand through a linker, allowing for the development of proteolysis targeting chimeras (PROTACs). Its applications include targeted protein degradation studies and the exploration of novel therapeutic strategies in various diseases.

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Cat. No.

A80893

CAS No.

2736510-38-4

CRBN ligand-750

CRBN ligand-750 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound serves as a valuable tool for the development of PROTACs (Proteolysis Targeting Chimeras) by enabling the targeted degradation of specific proteins through ubiquitin-mediated pathways. Its application in chemical biology underscores its potential in elucidating protein function and developing innovative therapeutic strategies.

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5 mg

$20.00

10 mg

$30.00

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Cat. No.

A80894

CAS No.

2766180-45-2

CRBN ligand-207

CRBN ligand-207 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN in protein degradation pathways. This compound serves as a crucial element for developing PROTACs (Proteolysis Targeting Chimeras) by linking to target protein ligands through a suitable linker. Its ability to promote targeted protein degradation makes it a valuable tool in cellular and molecular biology research, particularly in studies focused on ubiquitin-mediated proteolysis and the modulation of protein homeostasis.

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Cat. No.

A80895

CAS No.

2925099-54-1

CRBN ligand-341

CRBN ligand-341 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera), enabling targeted protein degradation. Its utilization aids in studying protein homeostasis and the modulation of cellular functions in various research applications.

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Cat. No.

A80896

CAS No.

2758531-21-2

CRBN ligand-885

CRBN ligand-885 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to create proteolysis-targeting chimeras (PROTACs), enabling targeted protein degradation. Its application is crucial in the study of protein homeostasis and the modulation of various cellular pathways.

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100 mg

$105.00

250 mg

$205.00

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Cat. No.

A80897

CAS No.

3031608-33-7

CRBN ligand-230

CRBN ligand-230 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN in targeted protein degradation applications. This compound can be conjugated to target protein ligands via a linker, thereby enabling the formation of PROTACs (Proteolysis Targeting Chimeras). CRBN ligand-230 is instrumental in research focused on ubiquitination processes and therapeutic strategies for targeted protein modulation.

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Cat. No.

A80898

CAS No.

2925096-31-5

CRBN ligand-559

CRBN ligand-559 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). It is valuable for research applications focused on targeted protein degradation pathways and the exploration of E3 ligase-mediated ubiquitination processes.

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Cat. No.

A80899

CAS No.

3023408-98-9

CRBN ligand-203

CRBN ligand-203 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). It serves a critical role in targeted protein degradation studies and is useful for research into therapeutic applications involving the modulation of protein levels within cells.

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Cat. No.

A80900

CAS No.

2925091-17-2

CRBN ligand-355

CRBN ligand-355 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to specific target protein ligands through a linker to create PROTACs (Proteolysis Targeting Chimeras), enabling targeted protein degradation. It serves as a valuable tool for researchers investigating protein dynamics, ubiquitination pathways, and therapeutic strategies in cancer and other diseases.

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Cat. No.

A80901

CAS No.

2925102-38-9

CRBN ligand-335

CRBN ligand-335 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the construction of PROTACs by linking it to other target protein ligands via a suitable linker. Its application supports the study of targeted protein degradation and the modulation of protein levels in various biological contexts.

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Cat. No.

A80902

CAS No.

2925095-98-1

CRBN ligand-561

CRBN ligand-561 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to assemble a PROTAC (Proteolysis Targeting Chimera) by linking it to a target protein ligand through a suitable linker. Research applications include targeted protein degradation and investigations into proteostasis mechanisms, offering insights into therapeutic strategies for various diseases.

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Cat. No.

A80903

CAS No.

2789679-89-4

CRBN ligand-411

CRBN ligand-411 is a small molecule ligand that targets the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment to specific protein substrates. This compound can be utilized in the development of proteolysis targeting chimeras (PROTACs) by linking to a target protein ligand through a suitable linker. CRBN ligand-411 supports research in targeted protein degradation, enabling the investigation of cellular processes and therapeutic applications in various diseases.

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Cat. No.

A80904

CAS No.

2925074-73-1

CRBN ligand-699

CRBN ligand-699 is a small molecule ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein, enabling targeted degradation of specific proteins when linked to a target protein ligand through a suitable linker. This compound is instrumental in the development of PROTACs (proteolysis-targeting chimeras) for research applications focused on ubiquitin-mediated protein turnover and targeted therapy strategies.

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Cat. No.

A80905

CAS No.

2925100-60-1

CRBN ligand-755

CRBN ligand-755 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), functioning to selectively recruit the CRBN protein. This compound is designed for use in PROTAC (protasome-targeting chimeras) development, allowing for targeted protein degradation in cellular studies. Its ability to link to a target protein ligand via a linker opens avenues for manipulating protein levels in various biological research applications.

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Cat. No.

A80906

CAS No.

3036607-75-4

CRBN ligand-162

CRBN ligand-162 is a ligand for the CRBN-type E3 ubiquitin ligase, facilitating the targeted degradation of proteins through the ubiquitin-proteasome system. This compound is utilized in the design and synthesis of PROTACs (Proteolysis Targeting Chimeras), which are powerful tools for selective protein degradation in various biological research applications. Its utilization promotes advancements in understanding protein function and therapeutic interventions in diseases linked to protein dysregulation.

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Cat. No.

A80907

CAS No.

2925082-29-5

CRBN ligand-636

CRBN ligand-636 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be utilized in the design of PROTACs (Proteolysis Targeting Chimeras) by linking it to a target protein ligand through a linker, enabling targeted ubiquitination and degradation of the desired protein. CRBN ligand-636 is valuable in research applications aimed at exploring protein function, degradation pathways, and therapeutic interventions in various diseases.

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Cat. No.

A80908

CAS No.

2925090-15-7

CRBN ligand-571

CRBN ligand-571 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be utilized to synthesize PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. Its distinctive mechanism of action makes it a valuable tool for probing protein degradation pathways and studying the dynamics of protein homeostasis in cellular systems.

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Cat. No.

A80909

CAS No.

2858741-81-6

CRBN ligand-616

CRBN ligand-616 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This reagent can be conjugated with a target protein ligand through a linker to generate a proteolysis-targeting chimeric molecule (PROTAC). It supports research in targeted protein degradation, offering potential applications in therapeutic development and cellular signaling studies.

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Cat. No.

A80910

CAS No.

2925095-36-7

CRBN ligand-631

CRBN ligand-631 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is instrumental in the design of PROTACs (Proteolysis Targeting Chimeras) by allowing the conjugation of a target protein ligand through a suitable linker. Its ability to modulate protein degradation pathways makes it valuable for research into targeted protein degradation and therapeutic applications.

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Cat. No.

A80911

CAS No.

2641512-73-2

CRBN ligand-209

CRBN ligand-209 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted recruitment of the CRBN protein. This compound can be conjugated to a specific target protein ligand through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). It is valuable for research applications focused on targeted protein degradation and exploring protein turnover mechanisms within cellular systems.

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Cat. No.

A80912

CAS No.

2925095-65-2

CRBN ligand-418

CRBN ligand-418 is a novel ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound is designed to facilitate the recruitment of CRBN to target proteins when conjugated via a linker, thereby enabling the formation of Proteolysis Targeting Chimeras (PROTACs). Its application in targeted protein degradation offers significant potential in therapeutic research and development.

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Cat. No.

A80913

CAS No.

2925082-19-3

CRBN ligand-695

CRBN ligand-695 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein in targeted protein degradation applications. It can be conjugated with a target protein ligand through a linker to create a PROTAC, enabling the selective degradation of specific proteins. This compound is valuable for research focused on targeted therapeutics and the manipulation of cellular protein levels.

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