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E3 Ligase Ligands

E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.

Cat. No.

A80863

CAS No.

2925095-42-5

CRBN ligand-707

CRBN ligand-707 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be effectively utilized to create proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its applications are vital in research related to targeted protein degradation and the modulation of cellular pathways governed by ubiquitin-proteasome system.

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25 mg

$125.00

50 mg

$195.00

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Cat. No.

A80864

CAS No.

2446913-98-8

CRBN ligand-396

CRBN ligand-396 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in cellular systems. This compound can be coupled with a ligand targeting a specific protein through a suitable linker to create a proteolysis-targeting chimera (PROTAC). It allows for targeted degradation of proteins, enabling nuanced investigations into protein function and regulation. Key applications include the study of ubiquitin-proteasome pathway mechanisms and protein homeostasis.

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Cat. No.

A80865

CAS No.

2925090-99-7

CRBN ligand-451

CRBN ligand-451 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for targeted protein degradation. It can be conjugated to a target protein ligand through a linker, enabling the construction of PROTACs (proteolysis-targeting chimeras). This compound is instrumental in research applications aimed at elucidating protein regulation and degradation mechanisms within cellular contexts.

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Cat. No.

A80866

CAS No.

2925080-67-5

CRBN ligand-518

CRBN ligand-518 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It functions by recruiting cereblon to target proteins, facilitating their ubiquitination and subsequent degradation. This compound is utilized in research applications involving proteolysis-targeting chimeras (PROTACs), enabling the targeted degradation of specific proteins within cellular systems.

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Cat. No.

A80867

CAS No.

2925099-89-2

CRBN ligand-339

CRBN ligand-339 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. It can be utilized to construct PROTACs (Proteolysis Targeting Chimeras) when linked to a specific target protein ligand via a suitable linker. This compound plays a critical role in targeted protein degradation research, enabling studies on ubiquitination and protein turnover.

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Cat. No.

A80868

CAS No.

2259851-81-3

CRBN ligand-184

CRBN ligand-184 is a selective ligand for CRBN-type E3 ubiquitin ligases. This compound plays a crucial role in the development of proteolysis-targeting chimeras (PROTACs), including the synthesis of PROTAC AU-24118. Its ability to engage E3 ligases provides valuable tools for targeted protein degradation research and the investigation of cellular protein dynamics.

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Cat. No.

A80869

CAS No.

2244684-41-9

(S,R,S)-AHPC 2-OH hydrochloride

(S,R,S)-AHPC 2-OH hydrochloride is a ligand for the E3 ubiquitin ligase VHL, facilitating the recruitment of the VHL protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of PROTACs for targeted protein degradation applications in chemical biology research. Its utility in studying ubiquitin-proteasome system pathways makes it a valuable tool for investigating protein regulation and degradation mechanisms.

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Cat. No.

A80870

CAS No.

2925091-52-5

CRBN ligand-259

CRBN ligand-259 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the targeted recruitment of the CRBN protein. This compound can be utilized to construct Proteolysis Targeting Chimeras (PROTACs) by linking it to a target protein ligand via a suitable linker. CRBN ligand-259 is instrumental in studies aimed at modulating protein degradation pathways, providing insights into protein homeostasis and potential therapeutic interventions.

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Cat. No.

A80871

CAS No.

2925075-46-1

CRBN ligand-639

CRBN ligand-639 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand using a linker to create a proteolysis-targeting chimera (PROTAC). CRBN ligand-639 is instrumental in elucidating ubiquitin-mediated protein degradation pathways and has applications in targeted protein degradation research.

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Cat. No.

A80872

CAS No.

3031608-49-5

CRBN ligand-685

CRBN ligand-685 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound serves as a crucial building block for the synthesis of PROTACs (proteolysis-targeting chimeras), enabling targeted protein degradation pathways. Researchers can utilize CRBN ligand-685 in studies of protein turnover, cellular degradation mechanisms, and the development of novel therapeutic strategies.

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Cat. No.

A80873

CAS No.

2642231-76-1

Desamino lenalidomide-7-CO

Desamino lenalidomide-7-CO is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound serves as a crucial component in the development of PROTACs (proteolysis-targeting chimeras) by enabling the linkage to target protein ligands through a suitable linker. Its application in targeted protein degradation research underscores its significance in investigating cellular pathways and therapeutic strategies.

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Cat. No.

A80874

CAS No.

2990057-63-9

3-(5-Bromo-2-chlorophenyl)piperidine-2,6-dione

3-(5-Bromo-2-chlorophenyl)piperidine-2,6-dione is a ligand for the CRBN-type E3 ubiquitin ligase, enabling the development of PROTAC (proteolysis-targeting chimeras) for targeted protein degradation. This compound facilitates the recruitment of ubiquitin ligases to specific proteins, highlighting its utility in studies focused on protein regulation and degradation pathways. Its application in drug discovery aims to enhance therapeutic strategies by modulating the cellular levels of target proteins.

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Cat. No.

A80875

CAS No.

2925088-80-6

CRBN ligand-506

CRBN ligand-506 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. This compound is valuable for research in cellular signaling, ubiquitination pathways, and the development of innovative therapeutic strategies.

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Cat. No.

A80876

CAS No.

2597167-25-2

Thalidomide-O-amido-PEG1-azide

Thalidomide-O-amido-PEG1-azide is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in cellular processes. This compound can be conjugated with a target protein ligand through a linking mechanism to create a proteolysis-targeting chimera (PROTAC). Its ability to modulate protein degradation pathways makes it a valuable tool for research in therapeutic applications and targeted protein degradation studies.

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Cat. No.

A80877

CAS No.

2925089-18-3

CRBN ligand-265

CRBN ligand-265 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this crucial protein. Its design enables the conjugation with target protein ligands through a linker, thereby allowing for the formation of PROTACs (proteolysis-targeting chimeras). This compound is valuable in studies focusing on targeted protein degradation and the modulation of specific cellular pathways.

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Cat. No.

A80879

CAS No.

2925090-58-8

CRBN ligand-356

CRBN ligand-356 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of PROTACs (Proteolysis Targeting Chimeras) by linking it to a target protein ligand through a suitable linker. Its key biological activity makes it valuable for research in targeted protein degradation and therapeutic applications in various diseases.

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Cat. No.

A80880

CAS No.

2925094-78-4

CRBN ligand-565

CRBN ligand-565 acts as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound enables the targeted recruitment of cereblon, facilitating the development of PROTACs through its connection to target protein ligands via a suitable linker. Its utility in research includes the study of targeted protein degradation pathways and the modulation of various biological processes mediated by ubiquitination.

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Cat. No.

A80881

CAS No.

2925087-71-2

CRBN ligand-434

CRBN ligand-434 acts as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera), a novel tool for targeted protein degradation. Its utility in research applications includes investigating the mechanisms of targeted ubiquitination and exploring therapeutic strategies for various diseases.

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Cat. No.

A80882

CAS No.

2925075-72-3

CRBN ligand-322

CRBN ligand-322 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be utilized to conjugate with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimeras). It is valuable for studying protein degradation pathways and exploring targeted protein degradation strategies in chemical biology and therapeutic development.

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Cat. No.

A80883

CAS No.

2925088-06-6

CRBN ligand-576

CRBN ligand-576 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein in cellular contexts. This compound can be connected to a target protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC). Its design allows for targeted protein degradation, making it a valuable tool in chemical biology and therapeutic development.

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Cat. No.

A80884

CAS No.

3031608-15-5

CRBN ligand-193

CRBN ligand-193 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). It is instrumental in studies aiming to harness targeted protein degradation as a therapeutic strategy. The application of CRBN ligand-193 advances research in drug development and cellular regulation.

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Cat. No.

A80885

CAS No.

2925073-36-3

CRBN ligand-281

CRBN ligand-281 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), functioning to facilitate the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of PROTAC (Proteolysis Targeting Chimera) molecules. Due to its specific interaction with CRBN, CRBN ligand-281 is valuable for studying targeted protein degradation mechanisms and the role of ubiquitin-proteasome pathways in cellular processes.

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Cat. No.

A80886

CAS No.

3052750-93-0

CRBN ligand-869

CRBN ligand-869 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of this protein for targeted protein degradation. This compound can be conjugated with a ligand specific to the target protein through a suitable linker to create a PROTAC (proteolysis-targeting chimera). CRBN ligand-869 is valuable for research applications in protein modulation and therapeutic discovery.

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Cat. No.

A80887

CAS No.

2925087-62-1

CRBN ligand-508

CRBN ligand-508 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the development of proteolysis-targeting chimeras (PROTACs). It is utilized in research applications involving targeted protein degradation and E3 ligase modulation.

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Cat. No.

A80888

CAS No.

2925075-23-4

CRBN ligand-426

CRBN ligand-426 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC). It is useful in studies related to targeted protein degradation and the modulation of cellular protein levels.

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